Collected Works of Nicholas Chiorazzi

Introduction

Photo of Nicholas Chiorazzi

Dr. Nicholas Chiorazzi is best known for his discovery, alongside Dr. Terence Hamblin, of the importance of IGHV mutations. This discovery allowed for the separation of patients into two major clinical groups: indolent clinical course and aggressive clinical course. Other important themes of his work include a detailed examination of immunoglobulins in IgG+ CLL. He has conducted an exhaustive investigation of antigens that might be involved in the immune process of this neoplastic transformation.

Dr. Chiorazzi received his medical degree from Georgetown University in 1970. He carried out his medical internship and residency at the North Shore Memorial, New York, and Rockefeller University hospitals. He had a two-year postdoctoral fellowship at Harvard in cellular immunology with Dr. David H. Katz and Dr. Baruj Benacerraf and he studied human immunology in the laboratory of Dr. Henry G. Kunkel, first as a visiting investigator and later as the deputy head after Dr. Kunkel’s death until the laboratory closed. Currently, he is head of the Karches Center for Chronic Lymphocytic Research at The Feinstein Institute for Medical Research. Among his numerous honors and awards, he has received the Rai Binet Medal for Outstanding Contributions to CLL Research.

Collected Works

1973

  • Moser KM, Guisan M, Bartimmo EE, Longo AM, Harsanyi PG, Chiorazzi N. In vivo and post mortem dissolution rates of pulmonary emboli and venous thrombi in the dog. Circulation. 1973 Jul;48(1):170-8. https://doi.org/10.1161/01.CIR.48.1.170

1974

1976

  • Chiorazzi N, Eshhar Z, Katz DH. Induction of immunological tolerance to the major antigenic determinant of penicillin: A therapeutic approach to penicillin allergy. Proc Natl Acad Sci U S A. 1976 Jun;73(6):2091-5. https://doi.org/10.1073/pnas.73.6.2091
  • Fox DA, Chiorazzi N, Katz DH. Hapten-specific IgE antibody responses in mice. V. Differential resistance of IgG and IgE B lymphocytes to X-irradiation. J Immunol. 1976 Nov;117(5 Pt.1):1622-8. https://www.jimmunol.org/content/117/5_Part_1/1622.long
  • Chiorazzi N, Fox DA, Katz DH. Hapten-specific IgE antibody responses in mice. VI. Selective enhancement of IgE antibody production by low doses of X-irradiation and by cyclophosphamide. J Immunol. 1976 Nov;117(5 Pt 1):1629-37. https://www.jimmunol.org/content/117/5_Part_1/1629.long
  • Katz DH, Chiorazzi N, McDonald J, Katz LR. Cell interactions between histoincompatible T an B lymphocytes. IX. The failure of histoincompatible cells is not due to suppression and cannot be circumvented by carrier-priming T cells with allogeneic macrophages. J Immunol. 1976 Nov;117(5 Pt.2):1853-9. https://www.jimmunol.org/content/117/5_Part_2/1853.long

1977

  • Chiorazzi N, Fox DA, Katz DH. Hapten-specific IgE antibody responses in mice. VII. Conversion of IgE “non-responder” strains to IgE “responders” by elimination of suppressor T cell activity. J Immunol. 1977 Jan;118(1):48-54. https://www.jimmunol.org/content/118/1/48.long
  • Chiorazzi N, Tung AS, Katz DH. Induction of a ragweed-specific allergic state in Ir-gene-restricted nonresponder mice. J Exp Med. 1977 Jul 1;146(1):302-7. https://doi.org/10.1084/jem.146.1.302
  • Chiorazzi N, Tung AS, Katz DH. Hapten-specific IgE antibody responses in mice. VIII. A possible new mechanism by which anti-lymphocyte serum enhances IgE antibody synthesis in vivo. J Immunol. 1977 Aug;119(2):685-93. https://www.jimmunol.org/content/119/2/685.long

1978

  • Tung AS, Chiorazzi N, Katz DH. Regulation of IgE antibody production by serum molecules. I. Serum from complete Freund’s adjuvant-immune donors suppresses irradiation-enhanced IgE production in low responder strains. J Immunol. 1978 Jun;120(6):2050-9. https://www.jimmunol.org/content/120/6/2050.long
  • Fu SM, Chiorazzi N, Wang CY, Montazeri G, Kunkel HG, Ko HS, Gottlieb AB. Ia-bearing T lymphocytes in man: Their identification and role in the generation of allogeneic helper activity. J Exp Med. 1978 Nov 1;148(5):1423-8. https://doi.org/10.1084/jem.148.5.1423
  • Fu SM, Chiorazzi N, Kunkel HG, Halper JP, Harris S. Induction of in vitro differentiation and immunoglobulin synthesis of human leukemic B lymphocytes. J Exp Med. 1978 Dec 1;148(6):1570-8. https://doi.org/10.1084/jem.148.6.1570

1979

  • Chiorazzi N, Ferrarini M, Montazeri G, Hoffman T, Fu SM. Generation of plaque-forming cells. Allogeneic effect and significance of monocyte removal.  In Fauci AS, Ballieux RE, eds. Antibody Production in Man: In Vitro Synthesis and Clinical Implications. New York, NY: Academic Press; 1979:169-272.
  • Fu SM, Chiorazzi N, Hurley JN, Halper JP, Kunkel HG. Differentiation of leukemic B lymphocytes in man. In Vogel HJ, Pernis B, eds. Cells of Immunoglobulin Synthesis. New York, NY: Academic Press; 1979:127-139.
  • Fu SM, Hurley J, Chiorazzi N, Kunkel HG. Differentiation in vitro of human B-type leukemia cells. In Cooper M, Mosier D, Scher I, Vitetta E, eds. B lymphocytes in the Immune Response. New York, NY: Elsevier-North Holland; 1979:277-284.
  • King TP, Kochoumian L, Chiorazzi N. Immunological properties of conjugates of ragweed pollen antigen E with methoxypolyethylene glycol or a copolymer of D-glutamic acid and D-lysine. J Exp Med. 1979 Feb 1;149(2):424-35. https://doi.org/10.1084/jem.149.2.424
  • Chiorazzi N, Fu SM, Montazeri G, Kunkel HG, Rai K, Gee T. T cell helper defect in patients with chronic lymphocytic leukemia. J Immunol. 1979 Mar;122(3):1087-90. https://www.jimmunol.org/content/122/3/1087.long
  • Chiorazzi N, Tung AS, Katz DH. Hapten-specific IgE antibody responses in mice. IX. Suppression of IgE antibody production by passive transfer of T cells from adjuvant-primed syngeneic mice. J Immunol. 1979 Apr;122(4):1495-501. https://www.jimmunol.org/content/122/4/1495.long
  • Gottlieb AB, Lahita RG, Chiorazzi N, Kunkel HG. Cellular immune function in systemic lupus erythematosus. Impairment of in vitro T-cell proliferation and in vivo antibody response to exogenous antigen. J Clin Invest. 1979 May;63(5):885-92. https://doi.org/10.1172/JCI109388
  • Chiorazzi N, Fu SM, Kunkel HG. Induction of polyclonal antibody synthesis by human allogeneic and autologous helper factors. J Exp Med. 1979 Jun 1;149(6):1543-8. https://doi.org/10.1084/jem.149.6.1543
  • Chiorazzi N, Fu SM, Kunkel HG. Induction of human antibody responses in vitro with emphasis on allogeneic helper factors. Immunol Rev. 1979;45:219-41. https://doi.org/10.1111/j.1600-065X.1979.tb00279.x
  • Fu SM, Chiorazzi N, Kunkel HG. Differentiation capacity and other properties of the leukemic cells of chronic lymphocytic leukemia. Immunol Rev. 1979;48:23-44. https://doi.org/10.1111/j.1600-065X.1979.tb00297.x

1980

  • Chiorazzi N, Fu SM, Kunkel HG. Activation of human B lymphocytes by MLR-derived helper factors and anti-immunoglobulins. In Pernis B, Vogel HJ, eds. Regulatory T Lymphocytes. New York, NY: Academic Press; 1980:235-250.
  • Chiorazzi N, Fu SM, Kunkel HG. Stimulation of human B lymphocytes by antibodies to IgM and IgG. Functional evidence for the expression of IgG on B lymphocyte surface membranes. Clin Immunol Immunopathol. 1980 Mar;15(3):301-13. https://doi.org/10.1016/0090-1229(80)90042-2
  • Yu DTY, Chiorazzi N, Kunkel HG. Helper factors derived from autologous mixed lymphocyte cultures. Cell Immunol. 1980 Mar 15;50(2):305-13. https://doi.org/10.1016/0008-8749(80)90285-3
  • Montazeri G, Chiorazzi N, Fu SM, Kunkel HG. Regulatory role of circulating monocytes in the differentiative and proliferative responses of human B lymphocytes. Clin Immunol Immunopathol. 1980 May;16(1):1-10. https://doi.org/10.1016/0090-1229(80)90160-9

1982

  • Chiorazzi N. The influences of antibodies to cell surface immunoglobulins on human B lymphocyte activation. In Fauci T, Ballieux R, eds. Human B Lymphocyte Function. Activation and Immunoregulation. New York, NY: Raven Press; 1982:47-60.
  • Ambinder JM, Chiorazzi N, Gibofsky A, Fotino M, Kunkel HG. Special characteristics of cellular immune function in normal individuals of the HLA-DR3 type. Clin Immunol Immunopathol. 1982 May;23(2):269-74. https://doi.org/10.1016/0090-1229(82)90113-1
  • Posnett DN, Chiorazzi N, Kunkel HG. Monoclonal antibodies with specificity for hairy cell leukemia cells. J Clin Invest. 1982 Aug;70(2):254–261. https://doi.org/10.1172/JCI110612
  • Chiorazzi N, Wasserman RL, Kunkel HG. Use of Epstein-Barr virus-transformed B cell lines for the generation of immunoglobulin-producing human B cell hybridomas. J Exp Med. 1982 Sep 1;156(3):930-5. https://doi.org/10.1084/jem.156.3.930

1983

  • Rodman TC, Pruslin FH, Chiorazzi N, Michelis MA, Winston R. p15, A nuclear‐associated protein of human sperm: Identification of four variants and their occurrence in normal and abnormal seminal cells. Gamete Res. 1983;8(2):129-147. https://doi.org/10.1002/mrd.1120080204
  • Lahita RG, Chiorazzi N, Gibofsky A, Winchester RJ, Kunkel HG. Familial systemic lupus erythematosus in males. Arthritis Rheum. 1983 Jan;26(1):39-44. https://doi.org/10.1002/art.1780260107

1984

  • Chiorazzi N, Bigler RD, Hatzfeld J, McCune JM. Distinct human leucoctye activation antigens defined by murine monoclonal antibodies AA1 and AA2. In Bernard A, Boumsell L, Dausett J, Milstein C, Scholssman SF, eds. Leucocyte Typing. New York, NY: Springer-Verlag; 1984:793-797.
  • Wang CY, Azzo W, Al-Katib A, Chiorazzi N, Knowles DM. Preparation and characterization of monoclonal antibodies recognizing three distinct differentiation antigens (BL1, BL2, BL3) on human B lymphocytes. J Immunol. 1984 Aug;133(2):684-91. https://www.jimmunol.org/content/133/2/684.long
  • Posnett DN, Bigler RD, Bushkin Y, Fisher DE, Mayer L, Wang CY, Chiorazzi N, Kunkel HG. T cell antiidiotypic antibodies reveal differences between two leukemias. J Exp Med. 1984 Aug 1;160(2):494-505. https://doi.org/10.1084/jem.160.2.494
  • Posnett DN, Wang CY, Chiorazzi N, Crow MK, Kunkel HG. An antigen characteristic of hairy cell leukemia cells is expressed on certain activated B cells. J Immunol. 1984 Sep;133(3):1635-40. https://www.jimmunol.org/content/133/3/1635.long
  • Schwarting R, Lane CL, Rinnooy Kan EA, Chiorazzi N, Wang CY. Human B cell stimulatory factor production by both T4+ and T8+ lymphocytes. Cell Immunol. 1984 Oct 1;88(1):41-8. https://doi.org/10.1016/0008-8749(84)90050-9

1985

  • Schwarting R, Welte K, Chiorazzi N, Ralph P, Lane CL, Long C, Wang CY. Biochemical characterization and purification of human B cell stimulatory factor (BSF). Eur J Immunol. 1985 Jun;15(6):632-7. https://doi.org/10.1002/eji.1830150619
  • Bigler RD, Posnett DN, Chiorazzi N. Stimulation of a subset of normal resting T lymphocytes by a monoclonal antibody to a cross reactive determinant of the human T cell antigen receptor. J Exp Med. 1985 Jun 1;161(6):1450-63. https://doi.org/10.1084/jem.161.6.1450
  • Rodman TC, Laurence J, Pruslin FH, Chiorazzi N, Winston R. Naturally occurring antibodies reactive with sperm proteins: Apparent deficiency in AIDS sera. Science. 1985 Jun 7;228(4704):1211-1215. https://doi.org/10.1126/science.3890184
  • Fisher DE, Reeves WH, Wisniewolski R, Lahita RG, Chiorazzi N. Temporal shifts from Sm to ribonucleoprotein reactivity in systemic lupus erythematosus. Arthritis Rheum. 1985 Dec;28(12):1348-55. https://doi.org/10.1002/art.1780281206

1986

  • Bigler RD, Chiorazzi N. A novel disulfide-linked cell surface molecule present on resting and activated human T lymphocytes. In Reinherz EL, Haynes BF, Nadler LM, Bernstein ID, eds. Leucocyte Typing II. Volume 1. Human T Lymphocytes. New York, NY:Springer-Verlag; 1986:503-512.
  • Mayer L, Kwan SP, Thompson C, Ko HS, Chiorazzi N, Waldmann T, Rosen F. Evidence for a defect in “switch” T cells in patients with immunodeficiency and hyperimmunoglobulinemia M. N Engl J Med. 1986 Feb 13;314(7):409-13. https://doi.org/10.1056/NEJM198602133140703
  • Chiorazzi N. Human monoclonal antibodies as probes to study autoimmune and allergic disorders. BioTechnology. 1986 Mar 1;4:210-218. https://doi.org/10.1038/nbt0386-210
  • Reeves WR, Fisher DE, Wisniewolski R, Gottlieb AB, Chiorazzi N. Psoriasis and Raynaud’s phenomenon associated with unusual U1 and U2 small nuclear ribonucleoprotein reactivity. N Engl J Med. 1986 Jul 10;315(2):105-111. https://doi.org/10.1056/NEJM198607103150207
  • Reeves WH, Chiorazzi N. Interaction between anti-DNA and anti-DNA-binding protein autoantibodies in cryoglobulins from sera of patients with systemic lupus erythematosus. J Exp Med. 1986 Oct 1;164(4):1029-42. https://doi.org/10.1084/jem.164.4.1029

1987

  • Bigler RD, Chiorazzi N. Private and shared idiotypic determinants of the human T cell antigen receptor. In Ferrarini M, Pernis B, eds. The Molecular Basis of B Cell Differentiation and Function. New York, NY: Plenum Press; 1987:123-130.
  • Chiorazzi N. An overview of cellular immune function in systemic lupus erythematosus. In Lahita R, ed. Systemic Lupus Erythematosus. New York, NY: Wiley; 1987:23-63.
  • Chiorazzi N. Stimulation of Lymphocytes with Antibodies to Surface Membrane-Bound Antigen Receptors. Methods Enzymol. 1987;150:92-104. https://doi.org/10.1016/0076-6879(87)50068-4
  • Chiorazzi N, Reeves WR. Description and partial characterization of a nucleolar RNA-associated autoantigen defined by a human monoclonal antibody. J Exp Med. 1987 Apr 1;165(4):1172-87. https://doi.org/10.1084/jem.165.4.1172
  • Stohl W, Posnett DN, Chiorazzi N. Induction of T cell-dependent B cell differentiation by anti-CD3 monoclonal antibodies. J Immunol. 1987 Mar 15;138(6):1667-73. https://www.jimmunol.org/content/138/6/1667.long

1988

  • May LT, Ghrayeb J, Santhanam U, Tatter S, Sthoeger Z, Helfgott D, Chiorazzi N, Grieninger G, Sehgal PB. Synthesis and secretion of multiple forms of β2-interferon/B-cell differentiation factor 2/hepatocyte-stimulating factor by human fibroblasts and monocytes. J Biol Chem. 1988 Jun 5;263(16):7760-6. http://www.jbc.org/content/263/16/7760.long
  • Bigler RD, Bushkin Y, Chiorazzi N. S152 (CD27): A modulating disulfide-linked T cell activation antigen. J Immunol. 1988 Jul 1;141(1):21-8. https://www.jimmunol.org/content/141/1/21.long
  • Sthoeger ZM, Chiorazzi N, Lahita RG. Regulation of the immune response by sex hormones. I. In vitro effects of estradiol and testosterone on pokeweed mitogen-induced B cell differentiation. J Immunol. 1988 Jul 1;141(1):91-8. https://www.jimmunol.org/content/141/1/91.long
  • Posnett DN, Gottlieb AB, Bussel J, Friedman SM, Chiorazzi N, Li Y, Szabo P, Farid N, Robinson MA. T cell antigen receptors in autoimmunity. J Immunol. 1988 Sep 15;141(6):1963-9. https://www.jimmunol.org/content/141/6/1963.long
  • Stohl W, Posnett DN, Chiorazzi N. Differential immunomodulation by anti-CD2 monoclonal antibodies of anti-CD3-induced T cell activation: Dependence upon the individual anti-CD3 monoclonal antibody used for activation. Cell Immunol. 1988 Oct 1;116(1):73-85. https://doi.org/10.1016/0008-8749(88)90211-0

1989

  • Auerbach AD, Koorse RE, Ghosh R, Venkatraj VS, Zhang M, Chiorazzi N. Complementation studies in Fanconi anemia. In Schroeder-Kurth TM, Auerbach AD, Obe G, eds. Fanconi anemia: clinical, cytogenic, and experimental aspects. Berlin, Germany: Springer Verlag; 1989: 213-225.
  • Sthoeger ZM, Wakai M, Tse DB, Vinciguerra VP, Allen SL, Budman DR, Lichtman SM, Schulman P, Weiselberg LR, Chiorazzi N. Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia. J Exp Med. 1989 Jan 1;169(1):255-68. https://doi.org/10.1084/jem.169.1.255
  • Novick DM, Ochshorn M, Ghali V, Croxson TS, Mercer WD, Chiorazzi N, Kreek MJ. Natural killer cell activity and lymphocyte subsets in parenteral heroin abusers and long-term methadone maintenance patients. J Pharmacol Exp Ther. 1989 Aug;250(2):606-10. http://jpet.aspetjournals.org/content/250/2/606.long
  • Baum CG, Chiorazzi N, Frankel S, Shepherd GM. Conversion of systemic lupus erythematosus to common variable hypogammaglobulinemia. Am J Med. 1989 Oct;87(4):449-56. https://doi.org/10.1016/S0002-9343(89)80831-9

1990

  • Saltz L, Knowles DM, Mechanic S, Pasley P, Wakai M, Chiorazzi N. Augmentation by cytochalasin B of antigen-receptor mediated activation of normal and malignant human B lymphocytes. Scand J Immunol. 1990 Jan;31(1):109-19. https://doi.org/10.1111/j.1365-3083.1990.tb02749.x
  • Zupo S, Dono M, Azzoni L, Chiorazzi N, Ferrarini M. Evidence for differential responsiveness of human CD5+ and CD5 B cell subsets to T cell-independent mitogens. Eur J Immunol. 1991 Feb;21(2):351-9. https://doi.org/10.1002/eji.1830210216
  • Mayer R, Logtenberg T, Strauchen J, Dimitriu-Bona A, Mayer L, Mechanic S, Chiorazzi N, Borche L, Dighiero G, Mannheimer-Lory A, Diamond B, Alt F, Bona C. CD5 and immunoglobulin V gene expression in B cell lymphomas and chronic lymphocytic leukemia. Blood. 1990 Apr 1;75(7):1518-24. https://doi.org/10.1182/blood.V75.7.1518.bloodjournal7571518

1992

1993

  • Kaplan L, Hyman K, Brooks R, Wakai M, Hashimoto S, Furie R, Chiorazzi N. Monoclonal IgM, IgG, and IgA human rheumatoid factors produced by synovial tissue-derived, EBV-transformed B cell lines. Clin Immunol Immunopathol. 1993 Jan;66(1):18-25. https://doi.org/10.1006/clin.1993.1003
  • Hashimoto S, Gregersen PK, Chiorazzi N. The human Ig-b cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes. J Immunol. 1993 Jan 15;150(2):491-8. https://www.jimmunol.org/content/150/2/491.long
  • Wakai M, Pasley P, Sthoeger ZM, Posnett DN, Brooks R, Hashimoto S, Chiorazzi N. Anti-CD23 monoclonal antibodies. Comparisons of epitope specificities and modulating capacities for IgE binding and production. Hybridoma. 1993 Feb;12(1):25-43. https://doi.org/10.1089/hyb.1993.12.25
  • Dono M, Zupo S, Masante R, Taborelli G, Chiorazzi N, Ferrarini M. Identification of two distinct CD5- B cell subsets from human tonsils with different responses to CD40 monoclonal antibody. Eur J Immunol. 1993 Apr;23(4):873-81. https://doi.org/10.1002/eji.1830230416
  • Koduru PRK, Lichtman SM, Smilari TF, Sun T, Goh JC, Karp L, Hall W, Hashimoto S, Chiorazzi N, Broome JD. Serial phenotypic, cytogenetic and molecular genetic studies in Richter’s syndrome: demonstration of lymphoma development from the chronic lymphocytic leukaemia cells. Br J Haematol. 1993 Nov;85(3):613-6. https://doi.org/10.1111/j.1365-2141.1993.tb03357.x

1994

  • Wakai M, Hashimoto S, Sthoeger ZM, Allen SL, Lichtman SM, Schulman P, Vinciguerra VP, Diamond B, Ferrarini M, Chiorazzi N. IgG+, CD5+ human chronic lymphocytic leukemia B cells. I. Production of IgG antibodies that exhibit diminished autoreactivity and IgG subclass skewing. Autoimmunity. 1994;19(1):39-48. https://doi.org/10.3109/08916939409008007
  • Hashimoto S, Chiorazzi N, Gregersen PK. The complete sequence of the human CD79b (lgβ/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism. Immunogenetics. 1994;40(2):145-149. https://doi.org/10.1007/BF00188178
  • Hashimoto S, Mohrenweiser HW, Gregersen PK, Chiorazzi N. Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79a (Ig-alpha/mb1) gene. Immunogenetics. 1994;40(4):287-95. https://doi.org/10.1007/BF00189974
  • Zupo S, Dono M, Massara R, Taborelli G, Chiorazzi N, Ferrarini M. Expression of CD5 and CD38 by human CD5- B cells: requirement for special stimuli. Eur J Immunol. 1994 Jun;24(6):1426-33. https://doi.org/10.1002/eji.1830240628
  • Jain R, Roncella S, Hashimoto S, Carbone A, Francia di Celle P, Foa R, Ferrarini M, Chiorazzi N. A potential role for antigen selection in the evolution of Burkitt’s lymphoma. J Immunol. 1994 Jul 1;153(1):45-52. https://www.jimmunol.org/content/153/1/45.long

1995

  • Jain RI, Fais F, Kaplan S, Sellars B, Brooks R, Chartash E, Furie R, Hashimoto S, Chiorazzi N. Ig H and L chain variable region gene sequence analyses of twelve synovial tissue-derived B cell lines producing IgA, IgG, and IgM rheumatoid factors. Structure/function comparisons of antigenic specificity, V gene sequence, and Ig isotype. Autoimmunity. 1995;22(4):229-43. https://doi.org/10.3109/08916939508995321
  • Mongini PKA, Blessinger CA, Chiorazzi N, Rajaram N, Rudich SM. A monovalent Cμ4-specific ligand enhances the activation of human B cells by membrane IgM cross-linking ligands. Int Immunol. 1995 Feb;7(2):317-30. https://doi.org/10.1093/intimm/7.2.317
  • Bullrich F, MacLachlan TK, Sang N, Druck T, Veronese L, Allen S, Chiorazzi N, Koff A, Heubner K, Croce C, Giordano A. Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. Cancer Res. 1995 Mar 15;55(6):1199-205. https://cancerres.aacrjournals.org/content/55/6/1199.long
  • Hashimoto S, Wakai M, Allen SL, Lichtman SM, Schulman P, Vinciguerra VP, Ferrarini M, Silver J, Chiorazzi N. Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells. J Exp Med. 1995 Apr 1;181(4):1507-17. https://doi.org/10.1084/jem.181.4.1507
  • Hashimoto S, Chiorazzi N, Gregersen PK. Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells. Mol Immunol. 1995 Jun;32(9):651-9. https://doi.org/10.1016/0161-5890(95)00023-8
  • Dono M, Hashimoto S, Ferrarini M, Chiorazzi N. In vivo isotype class switching in CD5+ chronic lymphocytic leukemia B cells. Ann N Y Acad Sci. 1995 Sep 29;764:478-481. https://doi.org/10.1111/j.1749-6632.1995.tb55868.x
  • Hashimoto S, Dono M, Vinciguerra V, Silver J, Chiorazzi N. Clonal heterogeneity in membrane expression of CD5 in a patient with chronic lymphocytic leukemia. Ann N Y Acad Sci. 1995 Sep 29;764:482-4. https://doi.org/10.1111/j.1749-6632.1995.tb55869.x

1996

  • Dighiero G, Kipps T, Schroeder HW, Chiorazzi N, Stevenson F, Silberstein LE, Caligaris-Cappio F, Ferrarini M. What is the CLL B-lymphocyte? Leuk Lymphoma. 1996;22(Suppl 2):13-39. https://doi.org/10.3109/10428199609102700
  • Dono M, Hashimoto S, Fais F, Trejo V, Allen SL, Lichtman SM, Schulman P, Vinciguerra VP, Sellars B, Gregersen PK, Ferrarini M, Chiorazzi N. Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification. Blood. 1996 Feb 15;87(4):1586-94. https://doi.org/10.1182/blood.V87.4.1586.bloodjournal8741586
  • Efremov DG, Ivanovski M, Siljanovski N, Pozzato G, Cevreska L, Fais F, Chiorazzi N, Batista FD, Burrone OR. Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia. Blood. 1996 May 1;87(9):3869-76. https://doi.org/10.1182/blood.V87.9.3869.bloodjournal8793869
  • Roncella S, Cutrona G, Favre A, Ulivi M, Fais F, Signorini A, Grossi CE, Chiorazzi N, Ferrarini M. Apoptosis of Burkitt’s lymphoma cells induced by specific interaction of surface IgM with a self-antigen: implications for lymphomagenesis in acquired immunodeficiency syndrome. Blood. 1996 Jul 15;88(2):599-608. https://doi.org/10.1182/blood.V88.2.599.bloodjournal882599
  • Dono M, Burgio VL, Tacchetti C, Favre A, Augliera A, Zupo S, Taborelli G, Chiorazzi N, Grossi CE, Ferrarini M. Subepithelial B cells in the human palatine tonsil. I. Morphologic, cytochemical, and phenotypic characterization of a novel subset. Eur J Immunol. 1996 Sep;26(9):2035-42. https://doi.org/10.1002/eji.1830260911
  • Dono M, Zupo S, Augliera A, Burgio V, Massara R, Melagrana A, Costa M, Grossi CE, Chiorazzi N, Ferrarini M. Subepithelial B cells in the human palatine tonsil. II. Functional characterization of a novel subset. Eur J Immunol. 1996 Sep;26(9):2043-9. https://doi.org/10.1002/eji.1830260912
  • Fais F, Sellars B, Ghiotto F, Yan X-J, Dono M, Allen SL, Budman D, Dittmar K, Kolitz J, Lichtman SM, Schulman P, Schuster M, Vinciguerra VP, Rai K, Stevenson F, Gregersen PK, Ferrarini M, Chiorazzi N. Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells. J Clin Invest. 1996 Oct 1;98(7):1659-66. https://doi.org/10.1172/JCI118961
  • Chiorazzi N. Human B cell subsets in health and disease: Phenotypic, functional, and genetic analyses. Nihon Rinsho Meneki Gakkai Kaishi. 1996 Dec;19(6):540.

1997

  • Dono M, Zupo S, Grossi CE, Chiorazzi N, Ferrarini M. Subepithelial B cells of the human tonsil. Chem Immunol. 1997;67:58-69.
  • Serrano D, Monteiro J, Allen SL, Kolitz J, Schulman P, Lichtman SM, Buchbinder A, Vinciguerra VP, Chiorazzi N, Gregersen PK. Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia. J Immunol. 1997 Feb 1;158(3):1482-9. https://www.jimmunol.org/content/158/3/1482.long
  • Chiorazzi N, Lahita RG Pavelka K, Ferrarini M. 1997. Preface. B Lymphocytes and Autoimmunity. Ann N Y Acad Sci. 1997 Apr;815:xiii-xiv. https://doi.org/10.1111/j.1749-6632.1997.tb52039.x
  • Dono M, Zupo S, Burgio VL, Augliera A, Tacchetti C, Favre A, Grossi CE, Chiorazzi N, Ferrarini M. Phenotypic and Functional Characterization of Human Tonsillar Subepithelial (SE) B Cells. Ann N Y Acad Sci. 1997 Apr;815:171-181. https://doi.org/10.1111/j.1749-6632.1997.tb52058.x
  • Campagna KJ, Chiorazzi N, Chang M-DY. The accessory cell function of B-CLL B cells. Ann N Y Acad Sci. 1997 Apr;815:427-431. https://doi.org/10.1111/j.1749-6632.1997.tb52094.x
  • Patki V, Monteiro J, Gregersen PK, Chiorazzi N.  Evidence for B cell oligoclonality in the blood and joints of patients with rheumatoid arthritis. Ann N Y Acad Sci. 1997 Apr;815:472-474. https://doi.org/10.1111/j.1749-6632.1997.tb52106.x
  • Rodman TC, Winston R, Sullivan JJ, Yan X-J, Chiorazzi N. An innate natural antibody is reactive with a cryptic sequence of lactoferrin exposed on sperm head surface. Proc Soc Exp Biol Med. 1997 Dec;216(3):404-9. https://doi.org/10.3181%2F00379727-216-44189
  • Campomenosi P, Fronza G, Ottaggio L, Roncella S, Inga A, Bogliolo M, Monti P, Asserto P, Moro F, Cutrona G, Bozzo S, Chiorazzi N, Abbondandolo A, Ferrarini M. Heterogeneous p53 mutations in a Burkitt lymphoma from an AIDS patient with monoclonal c-myc and VDJ rearrangements. Int J Cancer. 1997 Dec 10;73(6):816-21. https://doi.org/10.1002/(SICI)1097-0215(19971210)73:6%3C816::AID-IJC8%3E3.0.CO;2-5

1998

  • Schettino EW, Cerutti A, Chiorazzi N, Casali P. Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysis. J Immunol. 1998 Jan 15;160(2):820-30. https://www.jimmunol.org/content/160/2/820.long
  • Schiller B, Chiorazzi N, Farber BF. Methicillin-resistant Staphylococcal enterocolitis. Am J Med. 1998 Aug;105(2):164-6. https://doi.org/10.1016/S0002-9343(98)80056-9
  • Fais F, Ghiotto F, Hashimoto S, Sellars B, Allen SL, Schulman P, Vinciguerra VP, Rai K, Rassenti LZ, Kipps TJ, Dighiero G, Schroeder HW, Jr., Ferrarini M, Chiorazzi N. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest. 1998 Oct 15;102(8):1515-25. https://doi.org/10.1172/JCI3009

1999

  • Messmer BT, Sullivan JJ, Chiorazzi N, Rodman TC, Thaler DS. Two human neonatal IgM antibodies encoded by different variable-region genes bind the same linear peptide: Evidence for a stereotyped repertoire of epitope recognition. J Immunol. 1999 Feb 15;162(4):2184-92. https://www.jimmunol.org/content/162/4/2184.long
  • Musante L, Ulivi M, Chiorazzi N, Roncella S, Candiano G, Ferrarini M.  Identification of HSP-60 as the specific antigen of IgM produced by BRG-lymphoma cells. Electrophoresis. 1999 Apr-May;20(4-5):1092-7. https://doi.org/10.1002/(SICI)1522-2683(19990101)20:4/5%3C1092::AID-ELPS1092%3E3.0.CO;2-Y
  • Fais F, Gaidano G, Capello D, Gloghini A, Ghiotto F, Roncella S, Carbone A, Chiorazzi N, Ferrarini M. Immunoglobulin V region gene use and structure suggest antigen selection in AIDS-related primary effusion lymphomas. Leukemia. 1999 Jul;13(7):1093-9. https://doi.org/10.1038/sj.leu.2401436
  • Hirose N, Williams R, Alberts AR, Furie RA, Chartash EK, JainRI, Sison C, Lahita RG, Merrill JT, Cucurull E, Gharavi AE, Sammaritano LE, SalmonJE, Hashimoto S, Sawada T, Gregersen PK, Chiorazzi N. A role for the polymorphism at position 247 of the β2‐glycoprotein I gene in the generation of anti–β2‐glycoprotein I antibodies in the antiphospholipid syndrome. Arthritis Rheum. 1999 Aug;42(8):1655-61. https://doi.org/10.1002/1529-0131(199908)42:8%3C1655::AID-ANR14%3E3.0.CO;2-B
  • Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL, Buchbinder A, Budman D, Dittmar K, Kolitz J, Lichtman SM, Schulman P, Vinciguerra VP, Rai KR, Ferrarini M, Chiorazzi N. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999 Sep 15;94(6):1840-7. https://doi.org/10.1182/blood.V94.6.1840.418k06_1840_1847
  • Pritsch O, Troussard X, Magnac C, Mauro FR, Davi F, Payelle-Brogard B, Dumas G, Pulik M, Clerget F, Mandelli F, Chiorazzi N, Schroeder Jr HW, Leporrier M, Dighiero G. VH gene usage by family members affected with chronic lymphocytic leukemia. Br J Haematol. 1999 Dec;107(3):616-24. https://doi.org/10.1046/j.1365-2141.1999.01757.x

2000

  • Fais F, Ghiotto F, Hashimoto S, Dono M,Valetto A, Allen SL, Schulman P, Vinciguerra VP, Rai KR, Ferrarini M, Chiorazzi N. Immunoglobulin V gene sequence analyses distinguish two subsets of chronic lymphocytic leukemia B cells. In Zanetti M, Capra JD, eds. The Antibodies. Vol 6. Amsterdam, Netherlands: Harwood Academic; 2000:123-150.
  • Chiorazzi N. Antibodies. In Lahita RG, Chiorazzi N, Reeves WH, eds. Textbook of the Autoimmune Diseases. Philadelphia, PA: Lippincott Williams & Wilkins; 2000:11-18.
  • Damle RN, Fais F, Ghiotto F, Valetto A, Albesiano E, Wasil T, Batliwalla FM, Allen SL, Schulman P, Vinciguerra VP, Rai KR, Gregersen PK, Ferrarini M, Chiorazzi N. Chronic lymphocytic leukemia: A proliferation of B cells at two distinct stages of differentiation. Curr Top Microbiol Immunol. 2000;252:285-92.
  • Itoh K, Patki V, Furie RA, Chartash EK, Jain RI, Lane L, Asnis SE, Chiorazzi N. Clonal expansion is a characteristic feature of the B cell repertoire of patients with rheumatoid arthritis. Arthritis Res. 2000;2(1):50-8. https://doi.org/10.1186/ar68
  • Colombo M, Dono M, Gazzola P, Roncella S, Valetto A, Chiorazzi N, Mancardi GL, Ferrarini M. Accumulation of clonally-related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients. J Immunol. 2000 Mar 1;164(5):2782-9. https://doi.org/10.4049/jimmunol.164.5.2782
  • Damle RN, Wasil T, Allen SL, Schulman P, Rai KR, Ferrarini M, Chiorazzi N. Response: Updated data on V gene mutation status and CD38 expression in B-CLL. Blood. 2000 Apr 1; 95(7):2456-2457. https://doi.org/10.1182/blood.V95.7.2455
  • Capello D, Fais F, Vivenza D, Migliaretti, Chiorazzi N, Gaidano G, Ferrarini M. Identification of three subgroups of B-cell chronic lymphocytic leukemia based upon mutations of Bcl-6 and Ig V genes. Leukemia. 2000 May;14(5):811-5. https://doi.org/10.1038/sj.leu.2401766
  • Dono M, Zupo S, Leanza N, Melioli G, Fogli M, Melagrana A, Chiorazzi N, Ferrarini M. Heterogeneity of tonsillar subepithelial B lymphocytes, the splenic marginal zone equivalents. J Immunol. 2000 Jun 1;164(11):5596-604. https://doi.org/10.4049/jimmunol.164.11.5596
  • Itoh K, Meffre E, Albesiano E, Farber A, Dines D, Stein P, Asnis SE, Furie RA, Jain RI, Chiorazzi N. Immunoglobulin heavy chain variable region gene replacement as a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes. J Exp Med. 2000 Oct 16;192(8):1151-64. https://doi.org/10.1084/jem.192.8.1151
  • Fais F, Fronza G, Roncella S, Inga A, Campomenosi P, Cutrona G, Pezzolo A, Fedeli F, Abbondandolo A, Chiorazzi N, Pistoia V, Ferrarini M. Analysis of the stepwise genetic changes that occurred in an AIDS-related Burkitt’s lymphoma. Int J Cancer. 2000 Dec 1;88(5):744-50. https://doi.org/10.1002/1097-0215(20001201)88:5%3C744::AID-IJC10%3E3.0.CO;2-E

2001

  • Chiorazzi N, Ferrarini M. Immunoglobulin variable region gene characteristics and surface membrane phenotype define distinct subgroups of chronic lymphocytic leukemia cases with different clinical courses. In Cheson B, ed. Chronic Lymphocytic Leukemia. 2nd edition. New York, NY: Marcel Dekker; 2001:81-109.
  • Batliwalla FM, Damle RN, Metz C, Chiorazzi N, Gregersen PK. Simultaneous flow cytometric analysis of cell surface markers and telomere length: analysis of human tonsilar B cells. J Immunol Methods. 2001 Jan 1;247(1-2):103-9. https://doi.org/10.1016/S0022-1759(00)00297-0
  • Dono M, Zupo S, Massara R, Ferrini S, Melagrana A, Chiorazzi N, Ferrarini M. In vitro stimulation of human tonsillar subepithelial B cells: requirement for interaction with activated T cells. Eur J Immunol. 2001 Mar;31(3):752-6. https://doi.org/10.1002/1521-4141(200103)31:3%3C752::AID-IMMU752%3E3.0.CO;2-9
  • Maruno M, Furuyama K, Akagi R, Horie Y, Meguro K, Garbaczewski L, Chiorazzi N, Doss MO, Hassoun A, Mercelis R, Verstraeten L, Harper P, Floderus Y, Thunell S, Sassa S. Highly heterogeneous nature of delta-aminolevulinate dehydratase (ALAD) deficiencies in ALAD porphyria. Blood. 2001 May 15;97(10):2972-8. https://doi.org/10.1182/blood.V97.10.2972
  • Rosenwald A, Alizadeh AA, Widhopf G, Simon R, Davis RE, Yu X, Yang L, Pickeral OK, Rassenti LZ, Powell J, Botstein D, Byrd JC, Grever MR, Chiorazzi N, Wilson WH, Kipps TJ, Brown PO, Staudt LM. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med. 2001 Dec 3;194(11):1639-47. https://doi.org/10.1084/jem.194.11.1639

2002

  • Chiorazzi N, Damle N, Fais F, Ghiotto F, Rai KR, Ferrarini M. Chronic lymphocytic leukemia: a proliferation of B cells with distinct genetic and phenotypic features. Haematologica. 2002;87(Suppl 2):20-22, 2002.
  • Shan J, Liming Y, Xiao Q, Chiorazzi N, Budman D, Teichberg S, Xu H-P. TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells. Cancer Res. 2002 Jan 1;62(1):290-4. https://cancerres.aacrjournals.org/content/62/1/290.full-text.pdf
  • Damle RN, Ghiotto F, Valetto A, Albesiano E, Fais F, Yan X-J, Sison CP, Allen SL, Kolitz J,Schulman P, Vinciguerra VP, Budde P, Frey J, Rai KR, Ferrarini M, Chiorazzi N. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood. 2002 Jun 1;99(11):4087-93. https://doi.org/10.1182/blood.V99.11.4087
  • Gurrieri C, McGuire P, Zan H, Yan X-J, Cerutti A, Albesiano E, Allen SL, Vinciguerra V, Rai KR, Ferrarini M, Casali P, Chiorazzi N. Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal Ig VHDJH gene diversification. J Exp Med. 2002 Sep 2;196(5):629-639. https://doi.org/10.1084/jem.20011693
  • Kokkola R, Sundberg E, Ulfgren A-K, Palmblad K, Li J, Wang H, Ulloa L, Yang H, Yan X-J, Furie R, Chiorazzi N, Tracey KT, Andersson U, Harris HE. High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum. 2002 Oct;46(10):2598-603. https://doi.org/10.1002/art.10540
  • Kurth J, Perniok A, Schmitz R, Iking-Konert C, Chiorazzi N, Thompson KM, Winkler T, Rajewsky K, Küppers R. Lack of deleterious somatic mutations in the CD95 gene of plasmablasts from systemic lupus erythematosus patients and autoantibody-producing cell lines. Eur J Immunol. 2002 Dec;32(12):3785-92. https://doi.org/10.1002/1521-4141(200212)32:12%3C3785::AID-IMMU3785%3E3.0.CO;2-E

2003

  • Chiorazzi N, Ferrarini M. B Cell Chronic Lymphocytic Leukemia: Lessons learned from studies of the B cell antigen receptor. Annu Rev Immunol. 2003;21:841-94. Epub 2001 Dec 19. https://doi.org/10.1146/annurev.immunol.21.120601.141018
  • Keating MJ, Chiorazzi N, Messmer BT, Damle RN, Allen SL, Rai KR, Ferrarini M, Kipps TJ. Biology and treatment of chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program. 2003:153-75. https://doi.org/10.1182/asheducation-2003.1.153
  • Messmer D, Messmer B, Chiorazzi N. The global transcriptional maturation program and stimuli-specific gene expression profiles of human myeloid dendritic cells. Int Immunol. 2003 Apr;15(4):491-503. https://doi.org/10.1093/intimm/dxg052
  • Chiorazzi N, Lahita RG, Capra JD, Ferrarini M, Zabriskie JB. 2003. Preface. Immune Mechanisms and Disease. Ann N Y Acad Sci. 2003 Apr;987(1):1. https://doi.org/10.1111/j.1749-6632.2003.tb06026.x
  • Dono M, Zupo S, Colombo M, Massara R, Gaidano G, Taborelli G, Ceppa P, Burgio VL, Chiorazzi N, Ferrarini M. The human marginal zone B cell. Ann N Y Acad Sci. 2003 Apr;987(1):117-124. https://doi.org/10.1111/j.1749-6632.2003.tb06039.x
  • Foell J, McCausland M, Burch J, Chiorazzi N, Yan X-J, Suwyn C, O’Neil SP, Hoffmann MK, Mittler RS. CD137‐Mediated T Cell Co‐Stimulation Terminates Existing Autoimmune Disease in SLE‐Prone NZB/NZW F1 Mice. Ann N Y Acad Sci. 2003 Apr;987(1):230-5. https://doi.org/10.1111/j.1749-6632.2003.tb06052.x
  • Damle RN, Ghiotto F, Valetto A, Albesiano E, Allen SL, Schulman P, Vinciguerra VP, Rai KR, Ferrarini M, Chiorazzi N. B Cell Chronic Lymphocytic Leukemia. Distinct phenotypic features and replicative histories among subgroups. Ann N Y Acad Sci. 2003 Apr;987(1):302-304. https://doi.org/10.1111/j.1749-6632.2003.tb06068.x
  • Messmer D, Messmer B, Chiorazzi N. Facets of dendritic cell maturation: Environmental instructions lead to distinct transcriptional pattern in myeloid dendritic cells. Ann N Y Acad Sci. 2003 Apr;987(1):309-311. https://doi.org/10.1111/j.1749-6632.2003.tb06071.x
  • Foell JL, Strahotin S, O’Neil SP, McCausland MM, Suwyn C, Haber M, Chander PN, Bapat AS, Yan X-J, Chiorazzi N, Hoffmann MK, Mittler RS. CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice. J Clin Invest. 2003 May;111(10):1505-18. https://doi.org/10.1172/JCI17662
  • Rai KR, Chiorazzi N. Determining the clinical course and outcome in chronic lymphocytic leukemia. N Engl J Med. 2003 May 1;348(18):1797-9. https://doi.org/10.1056/NEJMe030032
  • Miura Y, Chu CC, Dines DN, Asnis SE, Furie RA, Chiorazzi N. Diversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion. Mol Med. 2003 May-Aug;9(5-8):166-74. https://doi.org/10.1007/BF03402181
  • Chiorazzi N. Aberrant somatic hypermutation and lymphomagenesis. Blood. 2003 Sep 1;102(5):1564-1565. https://doi.org/10.1182/blood-2003-06-2096
  • Albesiano E, Messmer BT, Damle RN, Allen SL, Rai KR, Chiorazzi N. Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone. Blood. 2003 Nov 1;102(9):3333-9. Epub 2003 Jul 10. https://doi.org/10.1182/blood-2003-05-1585
  • Auborn KJ, Qi M, Yan X-J, Teichberg S, Chen DZ, Chiorazzi N. Lifespan is prolonged in autoimmune-prone (NZB/NZW) F1 mice fed a diet supplemented with indole-3-carbinol. J Nutr. 2003 Nov;133(11):3610-3. https://doi.org/10.1093/jn/133.11.3610
  • Colombo M, Dono M, Gazzola P, Chiorazzi N, Mancardi G, Ferrarini M. Maintenance of B lymphocyte-related clones in the cerebrospinal fluid of multiple sclerosis patients. Eur J Immunol. 2003 Dec;33(12):3433-8. https://doi.org/10.1002/eji.200324144

2004

  • Damle RN, Batliwalla FM, Ghiotto F, Valetto A, Albesiano E, Sison C, Allen SL, Kolitz J, Vinciguerra VP, Kudalkar P, Wasil T, Rai KR, Ferrarini M, Gregersen PK, Chiorazzi N. Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations. Blood. 2004 Jan 15;103(2):375-82. Epub 2003 Sep 22. https://doi.org/10.1182/blood-2003-04-1345
  • Ghiotto F, Fais F, Valetto A, Albesiano E, Hashimoto S, Dono M, Ikematsu H, Allen SL, Kolitz J, Rai KR, Nardini M, Tramontano A, Ferrarini M, Chiorazzi N. Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J Clin Invest. 2004 Apr;113(7):1008-16. https://doi.org/10.1172/JCI19399
  • Messmer BT, Albesiano E, Messmer D, Chiorazzi N. The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process. Blood. 2004 May 1;103(9):3490-5. Epub 2003 Dec 24. https://doi.org/10.1182/blood-2003-10-3407
  • Ferrarini M, Chiorazzi N. Recent advances in the molecular biology and immunobiology of chronic lymphocytic leukemia. Semin Hematol. 2004 Jul;41(3):207-23. https://doi.org/10.1053/j.seminhematol.2004.05.003
  • Messmer D, Yang H, Telusma G, Knoll F, Li J, Messmer BT, Tracey KJ, Chiorazzi N. High mobility group box protein 1: an endogenous signal for dendritic cell maturation and Th1 polarization. J Immunol. 2004 Jul 1;173(1):307-13. https://doi.org/10.4049/jimmunol.173.1.307
  • Messmer D, Telusma G, Wasil T, Messmer BT, Allen SL, Rai KR, Chiorazzi N. Dendritic cells from chronic lymphocytic leukemia patients are normal regardless of Ig V gene mutation status. Mol Med. 2004 Jul-Dec;10(7-12):96-103. https://doi.org/10.2119/2005-00011.Messmer
  • Messmer BT, Albesiano E, Efremov DG, Ghiotto F, Allen SL, Kolitz J, Damle R, Fais F, Messmer D, Rai KR, Ferrarini M, Chiorazzi N. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med. 2004 Aug 16;200(4):519-25. https://doi.org/10.1084/jem.20040544

2005

  • Chiorazzi N, Rai KR, Ferrarini M. Chronic Lymphocytic Leukemia. N Engl J Med. 2005 Feb 24;352(8):804-15. https://doi.org/10.1056/NEJMra041720
  • Messmer BT, Messmer D, Allen SL, Kolitz JE, Kudalkar P, Cesar D, Murphy EJ, Koduru P, Ferrarini M, Zupo S, Cutrona G, Damle RN, Wasil T, Rai KR, Hellerstein MK, Chiorazzi N. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest. 2005 Mar;115(3):755-64. https://doi.org/10.1172/JCI23409
  • Hervé M, Xu K, Ng Y-S, Wardemann H, Albesiano E, Messmer BT, Chiorazzi N, Meffre E. Unmutated and mutated chronic lymphocytic leukemia derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Invest. 2005 Jun;115(6):1636-43. Epub 2005 May 2. https://doi.org/10.1172/JCI24387
  • Guzowski D, Chandrasekaram A, Gawel C, Palma J, Koenig J, Wang XP, Dosik M, Kaplan M, Chu C, Chavan S, Furie R, Albesiano E, Chiorazzi N, Goodwin L. Analysis of single nucleotide polymorphisms in the promoter region of interleukin-10 by denaturing high pressure liquid chromatography. J Biomol Tech. 2005 Jun;16(2):154-66. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291722/
  • Chiorazzi N, Hatzi K, Albesiano E. B-cell chronic lymphocytic leukemia, a clonal disease of B lymphocytes that vary in specificity for (auto)antigens. Ann N Y Acad Sci. 2005 Dec;1062:1-12. https://doi.org/10.1196/annals.1358.002
  • Chiorazzi N, Allen SL, Ferrarini M. Clinical and laboratory parameters that define clinically relevant B-CLL subgroups. Curr Top Microbiol Immunol. 2005;294:109-133. https://doi.org/10.1007/3-540-29933-5_7

2006

  • Chiorazzi N, Ferrarini M. Evolving view of the in-vivo kinetics of chronic lymphocytic leukemia B cells. Hematology Am Soc Hematol Educ Program. 2006:273-8, 512. https://doi.org/10.1182/asheducation-2006.1.273
  • Hirohata S, Miura Y, Tomita T, Yoshikawa H, Ochi T, Chiorazzi N. Enhanced expression of mRNA for nuclear factor kappaB1 (p50) in CD34+ cells of the bone marrow in rheumatoid arthritis. Arthritis Res Ther. 2006;8(2):R54. Epub 2006 Mar 6. https://doi.org/10.1186/ar1915
  • Cutrona G, Colombo M, Matis S, Reverberi D, Dono M, Tarantino V, Chiorazzi N, Ferrarini M. B lymphocytes in humans express ZAP-70 when activated in vivo. Eur J Immunol. 2006 Mar;36(3):558-69. https://doi.org/10.1002/eji.200526355
  • Thorsélius M, Krober A, Murray F, Thunberg U, Tobin G, Bühler A, Kienle D, Albesiano E, Maffei R, Dao-Ung LP, Wily J, Vilpo J, Laurell A, Merup M, Roos G, Karlsson K, Chiorazzi N, Marasca R, Döhner H, Stilgenbauer S, Rosenquist R. Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status. Blood. 2006 Apr 1;107(7):2889-94. Epub 2005 Nov 29. https://doi.org/10.1182/blood-2005-06-2227
  • Ryan EP, Pollock SJ, Kaur K, Felgar RE, Bernstein SH, Chiorazzi N, Phipps RP. Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells. Clin Immunol. 2006 Jul;120(1):76-90. Epub 2006 Feb 10. https://doi.org/10.1016/j.clim.2005.12.012
  • Yan X-J, Albesiano E, Zanesi N, Yancopoulos S, Sawyer A, Romano E, Petlickovski A, Efremov DG, Croce CM, Chiorazzi N. B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11713-8. Epub 2006 Jul 24. https://doi.org/10.1073/pnas.0604564103
  • Telusma G, Datta S, Mihajlov I, Ma W, Li J, Yang H, Newman W, Messmer BT, Minev B, Schmidt-Wolf IGH, Tracey KJ, Chiorazzi N, Messmer D. Dendritic cell activating peptides induce distinct cytokine profiles. Int Immunol. 2006 Nov;18(11):1563-73. Epub 2006 Sep 11. https://doi.org/10.1093/intimm/dxl089
  • Ghiotto F, Fais F, Albesiano E, Sison C, Valetto A, Gaidano G, Reinhardt J, Kolitz JE, Rai KR, Allen SL, Ferrarini M, Chiorazzi N. Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia. Mol Med. 2006 Nov-Dec;12(11-12):300-8. https://doi.org/10.2119/2006-00080.Ghiotto
  • Morabito F, Damle RN, Deaglio S, Keating M, Ferrarini M, Chiorazzi N. The CD38 ectoenzyme family: advances in basic science and clinical practice. Mol Med. 2006 Nov-Dec;12(11-12):342-4. https://doi.org/10.2119/2006-00110.Morabito

2007

  • Dono M, Burgio VL, Colombo M, Sciacchitano S, Reverberi D, Tarantino V, Cutrona G, Chiorazzi N, Ferrarini M. CD5+ B cells with the features of subepithelial B cells found in human tonsils. Eur J Immunol. 2007 Aug;37(8):2138-47. https://doi.org/10.1002/eji.200636887
  • Chiorazzi N. Cellular proliferation and death: forgotten features of chronic lymphocytic leukemia B cells. Best Pract Res Clin Haematol. 2007 Sep;20(3):399-413. https://doi.org/10.1016/j.beha.2007.03.007
  • Damle RN, Temburni S, Calissano C, Yancopoulos S, Banapour T, Sison C, Allen SL, Rai KR, Chiorazzi N. CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells. Blood. 2007 Nov 1;110(9):3352-9. Epub 2007 Aug 7. https://doi.org/10.1182/blood-2007-04-083832

2008

  • Chiorazzi N, Ferrarini M. Origin and nature of chronic lymphocytic leukemia B cells. In O’Brien S, Gribben JG, eds. Chronic Lymphocytic Leukemia. New York, NY: Informa Health Care; 2008:1-18.
  • Cutrona G, Colombo M, Matis S, Fabbi M, Spriano M, Callea V, Vigna E, Gentile M, Zupo S, Chiorazzi N, Morabito F, Ferrarini M. Clonal heterogeneity in chronic lymphocytic leukemia cells: superior response to surface IgM cross-linking in CD38, ZAP-70-positive cells. Haematologica. 2008 Mar;93(3):413-22. Epub 2008 Feb 20. https://doi.org/10.3324/haematol.11646
  • Li F-J, Ding S, Pan J, Shakhmatov MA, Kashentseva E, Wu J, Li Y, Soong S-J, Chiorazzi N, Davis RS. FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia. Blood. 2008 Jul 1;112(1):179-87. Epub 2008 Feb 26. https://doi.org/10.1182/blood-2008-01-131359
  • Weinstein JS, Nacionales DC, Lee PY, Kelly-Scumpia KM, Yan X-J, Scumpia PO, Vale-Cruz DS, Sobel E, Satoh M, Chiorazzi N, Reeves WH. Colocalization of antigen-specific T and B cells within ectopic lymphoid tissue following immunization with exogenous antigen. J Immunol. 2008 Sep 1;181(5):3259-67. https://doi.org/10.4049/jimmunol.181.5.3259
  • McCarthy BA, Boyle E, Wang XP, Guzowski D, Paul S, Catera R, Trott J, Yan X-J, Croce CM, Yancopoulos S, Messmer BT, Allen SL, Rai KR, Chiorazzi N. Surface Expression of Bcl-2 in Chronic Lymphocytic Leukemia and Other B-Cell Leukemias and Lymphomas Without a Breakpoint t(14;18). Mol Med. 2008 Sep-Oct;14(9-10):618-27. https://doi.org/10.2119/2008.00061.McCarthy
  • Catera R, Silverman GJ, Hatzi K, Seiler TM, Didier S, Zhang L, Herve M, Meffre E, Oscier DG, Vlassara H, Chen Y, Allen SL, Rai KR, Chu CC, Chiorazzi N. Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and chemical modifications. Mol Med. 2008 Nov-Dec;14(11-12):665-74. Epub 2008 Sep 25. https://doi.org/10.2119/2008-00102.Catera
  • Ghia P, Chiorazzi N, Stamatopoulos K. Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation. J Intern Med. 2008 Dec;264(6):549-62. https://doi.org/10.1111/j.1365-2796.2008.02030.x
  • Chu CC, Catera R, Hatzi K, Yan X-J, Zhang l, Wang XB, Fales HM, Allen SL, Kolitz JE, Rai KR, Chiorazzi N. Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. Blood. 2008 Dec 15;112(13):5122-9. Epub 2008 Sep 23. https://doi.org/10.1182/blood-2008-06-162024

2009

  • Chiorazzi N, Ferrarini M. Chronic lymphocytic leukemia. In Zabriskie JB, ed. Essential Clinical Immunology. New York, NY: Cambridge University Press;2009:119-130. https://doi.org/10.1017/CBO9780511575266.007
  • Grubor VD, Krasnitz A, Troge JE, Meth JL, Lakshmi B, Kendall JT, Yamrom B, Alex G, Pai D, Navin N, Hufnagel LA, Lee Y-H,  Cook K, Allen SL, Rai KR, Damle RN, Calissano C, Chiorazzi N, Wigler MH, Esposito D. Novel genomic alterations and clonal evolution in Chronic Lymphocytic Leukemia  revealed by Representational Oligonucleotide Microarray Analysis (ROMA). Blood. 2009 Feb 5;113(6):1294-303. Epub 2008 Oct 15. https://doi.org/10.1182/blood-2008-05-158865
  • Nacionales DC, Weinstein JS, Yan XJ, Albesiano E, Lee PY, Kelly-Scumpia KM, Lyons R, Satoh M, Chiorazzi N, Reeves WH. B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupus. J Immunol. 2009 Apr 1;182(7):4226-36. https://doi.org/10.4049/jimmunol.0800771
  • Chiorazzi N. The Association for Patient-Oriented Research. Clin Transl Sci. 2009 Jun;2(3):175-7. https://doi.org/10.1111/j.1752-8062.2008.00111.x
  • Yan X-J, Qi M, Telusma G, Yancopoulos S, Madaio M, Satoh M, Reeves WH, Teichberg S, Kohn N, Auborn K, Chiorazzi N. Indole-3-carbinol improves survival in lupus-prone mice by inducing tandem B- and T-cell differentiation blockades. Clin Immunol. 2009 Jun;131(3):481-94. Epub 2009 Mar 10. https://doi.org/10.1016/j.clim.2009.01.013
  • Seiler T, Woelfle M, Yancopoulos Y, Catera R, Li W, Hatzi K, Moreno C, Torres M, Paul S, Dohner H, Stilgenbauer S, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Chu CC, Chiorazzi N. Characterization of structurally-defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells. Blood. 2009 Oct 22;114(17):3615-24. Epub 2009 Aug 18. https://doi.org/10.1182/blood-2009-01-197822
  • Calissano C, Damle RN, Hayes G, Murphy EJ, Hellerstein MK, Sison C, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Chiorazzi N. In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia. Blood. 2009 Nov 26;114(23):4832-42. Epub 2009 Sep 29. https://doi.org/10.1182/blood-2009-05-219634

2010

  • Darzentas N, Hadzidimitriou A, Murray F, Hatzi K, Josefsson P, Laoutaris N, Moreno C, Anagnostopoulos A, Jurlander J, Tsaftaris A, Chiorazzi N, Belessi C, Ghia P, Rosenquist R, Davi F, Stamatopoulos K. A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence. Leukemia. 2010 Jan;24(1):125-32. Epub 2009 Sep 17. https://doi.org/10.1038/leu.2009.186
  • Chu CC, Catera R, Zhang L, Didier S, Agagnina BM, Damle RN, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Chiorazzi N. Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin. Blood. 2010 May 13;115(19):3907-15. Epub 2010 Jan 28. https://doi.org/10.1182/blood-2009-09-244251
  • Hayes GM, Busch R, Voogt J, Siah IM, Gee TA, Hellerstein MK, Chiorazzi N, Rai KR, Murphy EJ. Isolation of malignant B cells from patients with chronic lymphocytic leukemia (CLL) for analysis of cell proliferation: Validation of a simplified method suitable for multi-center clinical studies. Leuk Res. 2010 Jun;34(6):809-15. Epub 2009 Oct 24. https://doi.org/10.1016/j.leukres.2009.09.032
  • Wierda WG, Chiorazzi N, Dearden C, Brown JR, Montserrat E, Shpall E, Stilgenbauer S, Muneer S, Grever M. Chronic Lymphocytic Leukemia: New Concepts for Future Therapy. Clin Lymphoma Myeloma Leuk. 2010 Oct;10(5):369-78. https://doi.org/10.3816/CLML.2010.n.070
  • Lee H, Trott JS, Haque S, McCormick S, Chiorazzi N, Mongini PK. A cyclooxygenase-2/prostaglandin E2 pathway augments activation-induced cytosine deaminase expression within replicating human B cells. J Immunol. 2010 Nov 1;185(9):5300-14. Epub 2010 Oct 4. https://doi.org/10.4049/jimmunol.1000574
  • Damle RN, Calissano C, Chiorazzi N. Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells. Best Pract Res Clin Haematol. 2010 Mar;23(1):33-45. https://doi.org/10.1016/j.beha.2010.02.001
  • Caligaris-Cappio F, Chiorazzi N. Where is the biology of CLL leading us? Semin Cancer Biol. 2010 Dec;20(6):361-2. https://doi.org/10.1016/j.semcancer.2010.11.001

2011

  • Chiorazzi N, Ferrarini M. Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood. 2011 Feb 10;117(6):1781-91. Epub 2010 Dec 9. https://doi.org/10.1182/blood-2010-07-155663
  • Porakishvili N, Memon A, Vispute K, Kulikova N, Clark EA, Rai KR, Nathwani A, Damle RN, Chiorazzi N, Lydyard PM. CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells. Br J Haematol. 2011 May;153(4):486-98. Epub 2011 Mar 28. https://doi.org/10.1111/j.1365-2141.2011.08605.x
  • Bagnara D, Kaufman M, Calissano C, Marsilio S, Patten P, Chum P, Yan X-J, Allen SL, Lee A, Gregersen PK, Rai KR, Chiorazzi N. A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease. Blood. 2011 May 19;117(20):5463-72. Epub 2011 Mar 8. https://doi.org/10.1182/blood-2010-12-324210
  • Malavasi F, Deaglio S, Damle R, Cutrona G, Ferrarini M, Chiorazzi N. CD38 and chronic lymphocytic leukemia: a decade later. Blood. 2011 Sep 29;118(13):3470-8. Epub 2011 Jul 15. https://doi.org/10.1182/blood-2011-06-275610
  • Ghiotto F, Marcatili P, Tenca C, Calevo MG, Yan XJ, Albesiano E, Bagnara D, Colombo M, Cutrona G, Chu CC, Morabito F, Bruno S, Ferrarini M, Tramontano A, Fais F, Chiorazzi N. Mutation pattern of paired immunoglobulin heavy and light variable domains in chronic lymphocytic leukemia B cells. Mol Med. 2011;17(11-12):1188-95. Epub 2011 Jul 13. https://doi.org/10.2119/molmed.2011.00104
  • Chu CC, Zhang L, Dhayalan A, Agagnina BM, Magli AR, Fraher G, Didier S, Johnson LP, Kennedy WJ, Damle RN, Yan X-J, Patten PEM, Teichberg S, Koduru P, Kolitz JE, Allen SL, Rai KR, Chiorazzi N. Torque teno virus 10 isolated by genome amplification techniques from a patient with concomitant chronic lymphocytic leukemia and polycythemia vera. Mol Med. 2011;17(11-12):1338-48. Epub 2011 Sep 21. https://doi.org/10.2119/molmed.2010.00110
  • Calissano C, Damle RN, Marsilio S, Yan X-J, Yancopoulos S, Hayes G, Emson C, Murphy EJ, Hellerstein MK, Sison C, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Ivanovic I, Dozmorov IM, Roa S, Scharff MD, Li W, Chiorazzi N. Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells. Mol Med. 2011;17(11-12):1374-82. Epub 2011 Sep 23. https://doi.org/10.2119/molmed.2011.00360
  • Dozmorov I, Jarvis J, Saban R, Benbrook D, Wakeland E, Aksentijevich I, Ryan J, Chiorazzi N, Guthridge J, Drewe E, Tighe Patrick, Centola M, Lefkovits I. Internal standard-based analysis of microarray data2–Analysis of functional associations between HVE-genes. Nucleic Acids Res. 2011 Oct;39(18):7881-99. Epub 2011 Jun 28. https://doi.org/10.1093/nar/gkr503
  • Yan X-J, Dozmorov I, Li W, Yancopoulos S, Sison C, Centola M, Jain P, Allen SL, Kolitz JE, Rai KR, Chiorazzi N, Sherry B. Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia. Blood. 2011 Nov 10;118(19):5201-10. Epub 2011 Sep 12. https://doi.org/10.1182/blood-2011-03-342436

2012

  • Chiorazzi N. Implications of new prognostic markers in chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program. 2012;2012:76-87. https://doi.org/10.1182/asheducation-2012.1.76
  • Ponader S, Chen S-S, Buggy JJ, Balakrishnan K, Gandhi V, Wierda WG, Keating MJ, O’Brien S, Chiorazzi N, Burger JA. Bruton’s tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood. 2012 Feb 2;119(5):1182-9. Epub 2011 Dec 16. https://doi.org/10.1182/blood-2011-10-386417
  • Hwang K-K, Chen X,Kozink DM, Gustilo M, Marshall DJ, Whitesides J, Liao H-X, Catera R, Chu CC, Yan X-J, Luftig MA, Haynes BF, Chiorazzi N. Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by co-culture with macrophage feeder cells. Blood. 2012 Feb 16;119(7):e35-44. Epub 2011 Dec 12. https://doi.org/10.1182/blood-2011-08-371203
  • Jain P, Javdan M, Feger FK, Chiu PY, Sison C, Damle RN, Bhuiya TA, Sen F, Abruzzo LV, Burger JA, Rosenwald A, Allen SL, Kolitz JE, Rai KR, Chiorazzi N, Sherry B. Th17 and non-Th17 IL-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance. Haematologica. 2012 Apr;97(4):599-607. Epub 2011 Nov 4. https://doi.org/10.3324/haematol.2011.047316
  • Agathangelidis A, Darzentas N, Hadzidimitriou A, Brochet X, Murray F, Yan XJ, Davis Z, van Gastel-Mol EJ, Tresoldi C, Chu CC, Cahill N, Giudicelli V, Tichy B, Pedersen LB, Foroni L, Bonello L, Janus A, Smedby K, Anagnostopoulos A, Merle-Beral H, Laoutaris N, Juliusson G, di Celle PF, Pospisilova S, Jurlander J, Geisler C, Tsaftaris A, Lefranc MP, Langerak AW, Oscier DG, Chiorazzi N, Belessi C, Davi F, Rosenquist R, Ghia P, Stamatopoulos K. Stereotyped B-cell receptors in one third of chronic lymphocytic leukemia: toward a molecular classification with implications for targeted therapeutic interventions. Blood. 2012 May 10;119(19):4467-75. Epub 2012 Mar 13. https://doi.org/10.1182/blood-2011-11-393694
  • Lee H, Haque S, Nieto J, Trott J, Inman JK, McCormick S, Chiorazzi N, Mongini PK. A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion. J Immunol. 2012 Jun 15;188(12):6093-108. Epub 2012 May 18. https://doi.org/10.4049/jimmunol.1103037
  • Damle RN, Temburni S, Banapour T, Paul S, Mongini PKA, Allen SL, Kolitz JE, Rai KR, Chiorazzi N. T-cell independent, B-cell receptor-mediated induction of telomerase activity differs among IGHV mutation-based subgroups of chronic lymphocytic leukemia patients. Blood. 2012 Sep 20;120(12):2438-49. Epub 2012 Aug 8. https://doi.org/10.1182/blood-2012-02-409110
  • Patten PE, Chu CC, Albesiano E, Damle RN, Yan XJ, Kim D, Zhang L, Magli AR, Barrientos J, Kolitz JE, Allen SL, Rai KR, Roa S, Mongini PK, MacCarthy T, Scharff MD, Chiorazzi N. IGHV unmutated and mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions. Blood. 2012 Dec 6;120(24):4802-11. Epub 2012 Oct 15. https://doi.org/10.1182/blood-2012-08-449744

2013

  • Patten PEM, Chu CC, Chiorazzi N. B-cell chronic lymphocytic leukemia/lymphoma. In Carbone A, Younes A, eds. Non-Hodgkin Lymphomas: Advanced Diagnostics & Personalized Therapies. London, UK: Future Medicine Ltd; 2013:196-214. https://doi.org/10.2217/ebo.12.257
  • Chiorazzi N, Efremov D. Chronic Lymphocytic Leukemia: A tale of one or two signals? Cell Res. 2013 Feb;23(2):182-5. Epub 2012 Nov 13. https://doi.org/10.1038/cr.2012.152
  • Cesano A, Perbellini O, Evensen E, Chu CC, Cioffi F, Ptacek J, Damle RN, Chignola R, Cordeiro J, Yan XJ, Hawtin RE, Nichele I, Ware JR, Cavallini C, Lovato O, Zanotti R, Rai KR, Chiorazzi N, Pizzolo G, Scupoli MT. Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies. Haematologica. 2013 Apr;98(4):626-34. Epub 2012 Nov 9. https://doi.org/10.3324/haematol.2012.071910
  • Chen S-S, Batliwalla F, Holodick N, Yan X-J, Yancopoulos S, Croce CM, Rothstein TL, Chiorazzi N. Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):E1500-7. Epub 2013 Apr 2. https://doi.org/10.1073/pnas.1300616110
  • Marcatili P, Ghiotto F, Tenca C, Chailyan A, Mazzarello AN, Yan X-J, Colombo M, Albesiano E, Bagnara D, Cutrona G, Morabito F, Bruno S, Ferrarini M, Chiorazzi N, Tramontano A, Fais F. Igs expressed by chronic lymphocytic leukemia B cells show limited binding-site structure variability. J Immunol. 2013 Jun 1;190(11):5771-8. Epub 2013 May 1. https://doi.org/10.4049/jimmunol.1300321
  • Liu Y, Higgins CD, Overstreet CM, Rai KR, Chiorazzi N, Lai JR. Peptides that specifically bind to an antibody from a chronic lymphocytic leukemia clone expressing unmutated immunoglobulin variable region genes. Mol Med. 2013 Aug 28;19:245-52. https://doi.org/10.2119/molmed.2013.00082
  • Chu CC, Patten PEM, MacCarthy T, Yan X-J, Kolitz JE, Allen SL, Barrientos JC, Rai KR, Chiorazzi N. Detection of de novo IGHV mutations by ultra-deep sequencing from in vitro activated B-cell chronic lymphocytic leukemia cells: evidence for activation induced deaminase function. Proceedings of the 15th International Congress of Immunology (22-27 August 2013, Milan, Italy). https://doi.org/10.3389/conf.fimmu.2013.02.00093
  • Nakahara H, Herrin BR, Alder MN, Catera R, Yan X-J, Chiorazzi N, Cooper MD. Chronic lymphocytic leukemia monitoring with a Lamprey idiotope-specific antibody. Cancer Immunol Res. 2013 Oct;1(4):223-8. https://doi.org/10.1158/2326-6066.CIR-13-0052
  • Strefford JC, Sutton LA, Baliakas P, Agathangelidis A, Malčíková J, Plevova K, Scarfó L, Davis Z, Stalika E, Cortese D, Cahill N, Pedersen LB, di Celle PF, Tzenou T, Geisler C, Panagiotidis P, Langerak AW, Chiorazzi N, Pospisilova S, Oscier D, Davi F, Belessi C, Mansouri L, Ghia P, Stamatopoulos K, Rosenquist R. Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2.  Leukemia. 2013 Nov;27(11):2196-9. Epub 2013 Apr 5. https://doi.org/10.1038/leu.2013.98
  • Burger JA, Chiorazzi N. B cell receptor signaling in chronic lymphocytic leukemia. Trends Immunol. 2013 Dec;34(12):592-601. Epub 2013 Aug 5. https://doi.org/10.1016/j.it.2013.07.002

2014

  • Haque S, Yan XJ, Rosen L, McCormick S, Chiorazzi N, Mongini PKA. Effects of prostaglandin E2 on p53 mRNA transcription and p53 mutagenesis during T-cell-independent human B-cell clonal expansion. FASEB J. 2014 Feb;28(2):627-43. Epub 2013 Oct 21. https://doi.org/10.1096/fj.13-237792
  • Hwang KK, Trama AM, Kozink DM, Chen X, Wiehe K, Cooper AJ, Xia SM, Wang M, Marshall DJ, Whitesides J, Alam M, Tomaras GD, Allen SL, Rai KR, McKeating J, Catera R, Yan XJ, Chu CC, Kelsoe G, Liao HX, Chiorazzi N, Haynes BF. IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria. PLoS One. 2014 Mar 10;9(3):e90725. https://doi.org/10.1371/journal.pone.0090725
  • Houldsworth J, Guttapalli A, Thodima V, Yan XJ, Mendiratta G, Zielonka T, Nanjangud G, Chen W, Patil S, Mato A, Brown JR, Rai K, Chiorazzi N, Chaganti RSK. Genomic imbalance defines three prognostic groups for risk stratification of chronic lymphocytic leukemia patients. Leuk Lymphoma. 2014 Apr;55(4):920-8. Epub 2013 Nov 12. https://doi.org/10.3109/10428194.2013.845882
  • Chen SS, Chiorazzi N. Murine genetically engineered and human xenograft models of chronic lymphocytic leukemia. Semin Hematol. 2014 Jul;51(3):188-205. Epub 2014 May 22. https://doi.org/10.1053/j.seminhematol.2014.05.001
  • Baliakas P, Hadzidimitriou A, Sutton LA, Minga E, Agathangelidis A, Nichelatti M, Tsanousa A, Scarfò L, Davis Z, Yan XJ, Shanafelt T, Plevova K, Sandberg Y, Vojdeman FJ, Boudjogra M, Tzenou T, Chatzouli M, Chu CC, Veronese S, Gardiner A, Mansouri L, Smedby KE, Pedersen LB, van Lorn K, Giudicelli V, Francova HS, Nguyen-Khac F, Panagiotidis P, Juliusson G, Angelis L, Anagnostopoulos A, Lefranc MP, Facco M, Trentin L, Catherwood M, Montillo M, Geisler CH, Langerak AW, Pospisilova S, Chiorazzi N, Oscier D, FJelinek D, Darzentas N, Belessi C, Davi F, Rosenguist R, Ghia P, Stamatopoulos C. Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study. Lancet Haematol. 2014 Nov;1(2):e74-84. Epub 2014 Nov 3. https://doi.org/10.1016/S2352-3026(14)00005-2

2015

  • Xochelli A, Agathangelidis A, Kavakiotis J, Minga E, Sutton LA, Baliakas P, Chouvarda I, Giudicelli V, Vlahavas I, Maglaveras N, Bonello L, Trentin L, Tedeschi A, Panagiotidis P, Geisler C, Langerak AW, Pospisilova S, Jelinek DF, Oscier D, Chiorazzi N, Darzentas N, Davi F, Ghia P, Rosenquist R, Hadzidimitriou A, Belessi C, Lefranc M-P, Stamatopoulos K. Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukemia. Immunogenetics. 2015 Jan;67(1):61-6. Epub 2014 Nov 12. https://doi.org/10.1007/s00251-014-0812-3
  • Baliakas P, Agathangelidis A, Hadzidimitriou A, Sutton LA, Minga E, Tsanousa A, Scarfo L, Davis Z, Yan XJ, Shanafelt T, Plevova K, Sandberg Y, Vojdeman FJ, Boudjogra M, Tzenou T, Chatzouli M, Chu CC, Veronese S, Gardiner A, Mansouri L, Smedby KE, Pedersen LB, Moreno D, Van Lom K, Giudicelli V, Francova HS, Nguyen-Khac F, Panagiotidis P, Juliusson G, Angelis L, Anagnostopoulos A, Lefranc MP, Facco M, Trentin L, Catherwood M, Montillo M, Geisler CH, Langerak AW, Pospisilova S, Chiorazzi N, Oscier D, Jelinek DF, Darzentas N, Belessi C, Davi F, Ghia P, Rosenquist R, Stamatopoulos K. Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations. Blood. 2015 Jan 29;125(5):856-9. Epub 2014 Dec 17. https://doi.org/10.1182/blood-2014-09-600874
  • Porakishvili N, Vispute K, Steele AJ, Rajakaruna N, Kulikova N, Tsertsvadze T, Nathwani A, Damle RN, Clark EA, Rai KR, Chiorazzi N, Lydyard PM. Rewiring of sIgM-mediated intracellular signaling through the CD180 Toll-like receptor. Mol Med. 2015 Apr;21(1):46-57. Epub 2015 Jan 14. https://doi.org/10.2119/molmed.2014.00265
  • Sun LL, Ellerman D, Mathieu M, Hristopoulos M, Chen X, Li Y, Yan X, Clark R, Reyes A, Stefanich E, Mai E, Young J, Johnson C, Huseni M, Wang G, Wang X, Chen Y, Wang P, Wang H, Dybdal N, Chu YW, Chiorazzi N, Scheer JM, Junttila T, Totpal K, Dennis MS, Ebens A. Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies. Sci Transl Med. 2015 May 13;7(287):287ra70. https://doi.org/10.1126/scitranslmed.aaa4802
  • Chiorazzi N. A spoonful of sugar helps lymphoma cells go up. Blood. 2015 May 21;125(21):3215-6. https://doi.org/10.1182/blood-2015-04-636209
  • Mansouri L, Sutton L-A, Ljungström V, Bondza S, Arngården L, Bhoi S, Larsson J, Cortese D, Kalushkova A, Plevova K, Young E, Gunnarsson R, Falk-Sörqvist E, Lönn P, Muggen AF, Yan X-J, Sander B, Enblad G, Smedby KE, Juliusson G, Belessi C, Rung J, Chiorazzi N, Strefford JC, Langerak AW, Pospisilova S, Davi F, Hellström M, Jernberg-Wiklund H, Ghia P, Söderberg O, Stamatopoulos K, Nilsson M, Rosenquist R. Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia. J Exp Med. 2015 Jun 1;212(6):833-43. Epub 2015 May 18. https://doi.org/10.1084/jem.20142009
  • Gounari M, Ntoufa S, Apollonio B, Papakonstantinou N, Ponzoni M, Chu CC, Rossi D, Gaidano G, Chiorazzi N, Stamatopoulos K, Ghia P. Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8. Blood. 2015 Jun 4;125(23):3580-7. Epub 2015 Apr 21. https://doi.org/10.1182/blood-2014-09-603217
  • Messmer D, Lorrain K, Stebbins K, Bravo Y, Stock N, Cabrera G, Correa L, Chen A, Jacintho J, Chiorazzi N, Yan XJ, Spaner D, Prasit P, Lorrain D. A Selective Novel Peroxisome Proliferator-Activated Receptor (PPAR)-α Antagonist Induces Apoptosis and Inhibits Proliferation of CLL Cells In Vitro and In Vivo. Mol Med. 2015 Jun 9;21:410-9. https://doi.org/10.2119/molmed.2015.00139
  • Mongini PKA Gupta R, Boyle E, Nieto J, Lee H, Stein J, Bandovic J, Stankovic T, Barrientos J, Kolitz JE, Allen SL, Rai K, Chu CC, Chiorazzi N. TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells. J Immunol. 2015 Aug 1;195(3):901-23. Epub 2015 Jul 1. https://doi.org/10.4049/jimmunol.1403189
  • McCarthy BA, Yancopoulos S, Tipping M, Yan X-J, Wang XP, Bennett F, Li W, Lesser M, Paul S, Boyle E, Moreno C, Catera R, Messmer BT, Cutrona G, Ferrarini M, Kolitz JE, Allen SL, Rai KR, Rawstron AC, Chiorazzi N. A seven-gene expression panel distinguishing clonal expansions of pre-leukemic and chronic lymphocytic leukemia B cells from normal B lymphocytes. Immunol Res. 2015 Dec;63(1-3):90-100. https://doi.org/10.1007/s12026-015-8688-3
  • Sherry B, Jain P, Chiu PY, Leung L, Allen SL, Kolitz JE, Rai KR, Barrientos J, Liang S, Hawtin R, Chiorazzi N. Identification and characterization of distinct IL-17F expression patterns and signaling pathways in chronic lymphocytic leukemia and normal B lymphocytes. Immunol Res. 2015 Dec;63(1-3):216-27. https://doi.org/10.1007/s12026-015-8722-5
  • Sarkar M, Liu Y, Morimoto J, Peng H, Aquino C, Rader C, Chiorazzi N, Kodadek T. Recognition of antigen-specific B-cell receptors from chronic lymphocytic leukemia patients by synthetic antigen surrogates. Chem Biol. 2014 Dec 18;21(12):1670-9. Epub 2014 Nov 26. https://doi.org/10.1016/j.chembiol.2014.10.010

2016

  • Cui X, Zhang L, Magli AR, Catera R, Yan XJ, Griffin DO, Rothstein TL, Barrientos J, Kolitz JE, Allen SL, Rai KR, Chiorazzi N, Chu CC. Cytoplasmic myosin exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability. Leukemia. 2016 Jan;30(1):74-85. Epub 2015 Jul 29. https://doi.org/10.1038/leu.2015.204
  • Chen S-S, Chang BY, Chang S, Tong T, Ham S, Sherry BA, Burger JA, Rai KR, Chiorazzi N. BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia. Leukemia. 2016 Apr;30(4):833-43. Epub 2015 Nov 9. https://doi.org/10.1038/leu.2015.316
  • Ljungström V, Cortese D, Young E, Pandzic T, Mansouri L, Plevova K, Ntoufa S, Baliakas P, Clifford, Sutton L-A, Blakemore S, Stavroyianni N, Agathangelidis A, Rossi D, Höglund M, Kotaskova J, Juliusson G, Belessi C, Chiorazzi N, Panagiotidis P, Langerak AW, Smedby KE, Oscier D, Gaidano G, Schuh A, Davi F, Pott C, Strefford JC, Jonathan C. Trentin JC, Pospisilova S, Ghia P, Stamatopoulos K, Sjöblom T, Rosenquist. Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations. Blood. 2016 Feb 25;127(8):1007-16. Epub 2015 Dec 16. https://doi.org/10.1182/blood-2015-10-674572
  • Sarkar M, Liu Y, Qi J, Peng H, MorimotoJ, Rader C, Chiorazzi N, Kodadek T. Targeting stereotyped B cell receptors from chronic lymphocytic leukemia patients with synthetic antigen surrogates. J Biol Chem. 2016 Apr 1;291(14):7558-70. Epub 2016 Feb 5. https://doi.org/10.1074/jbc.M115.701656
  • Patten PEM, Ferrer G, Chen S-S, Simone R, Marsilio S, Yan X-J, Gitto Z,Yuan C,Kolitz JE, Barrientos J, Allen SL, Rai KR, MacCarthy T, Chu CC, Chiorazzi N. Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a nonclassical Th1-dependent, Bcl-6–deficient process. JCI Insight. 2016 Apr 7;1(4). pii: e86288. https://doi.org/10.1172/jci.insight.86288
  • Yigit B, Halibozek PJ, Chen S-S, O’Keeffe MS, Arnason J, Avigan D, Gattei V, Chiorazzi N, Wang N, Engel P, Terhorst C. A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells. Oncotarget. 2016 May 3;7(18):26346-60. https://doi.org/10.18632/oncotarget.8378
  • Guo B, Zhang L, Chiorazzi N, Rothstein T. IL-4 rescues surface IgM expression in chronic lymphocytic leukemia. Blood. 2016 Jul 28;128(4):553-62. Epub 2016 May 25. https://doi.org/10.1182/blood-2015-11-682997
  • Sutton L-A, Young E, Baliakas P, Hazidimitriou A, Moysiadis T, Plevova K, Rossi D, Kminkova J, Stalika E, Pedersen LB, Malcikova J, Agathangelidis A, Davis Z, Mansouri L, Scarfo L, Boudjoghra M, Navarro A, Muggen AF, Yan X-J, Nguyen-Khac F, Larrayoz M, Panagiotidis P, Chiorazzi N, Niemann CU, Belessi C, Campo E, Strefford JC, Langerak AW, Oscier D, Gaidano G, Pospisilova S, Davi F, Ghia P, Stamatopoulos K, Rosenquist. Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors. Haematologica. 2016 Aug;101(8):959-67. Epub 2016 May 19. https://doi.org/10.3324/haematol.2016.141812
  • Hatzi K, Catera R, Moreno Atanasio C, Fischetti VA, Allen SL, Kolitz JE, Rai KR, Chu CC, Chiorazzi N. Chronic lymphocytic leukemia immunoglobulins display bacterial reactivity that converges and diverges from auto-/poly-reactivity and IGHV mutation status. Clin Immunol. 2016 Nov;172:44-51. Epub 2016 Aug 29. https://doi.org/10.1016/j.clim.2016.08.020
  • Serra S, Brusa D, Vaisitti T, Audrito V, Buonincontri R, Bologna C, Chen S-S, Coscia M, Jaksic O, Inghirami G, Rossi D, Furman R, Robson S, Gaidano G, Chiorazzi N, Deaglio S. Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment. Blood Adv. 2016 Nov 22;1(1):47-61. https://doi.org/10.1182/bloodadvances.2016000984

2017

  • Burger JA, Li KW, Keating MJ, Sivina M, Amer AM, Garg N, Ferrajoli A, Huang X, Kantarjian H, Wierda WG, O’Brien S, Hellerstein MK, Turner SM, Emson CL, Chen S-S, Yan X-J, Wodarz D, Chiorazzi N. Leukemia cell proliferation and death in chronic lymphocytic leukemia patients on therapy with the BTK inhibitor ibrutinib. JCI Insight. 2017 Jan 26;2(2):e89904. https://doi.org/10.1172/jci.insight.89904
  • Yuan C, Chu CC, Yan X-J, Bagnara D, Chiorazzi N, MacCarthy T. The number of overlapping AID hotspots in germline IGHV genes is inversely correlated with mutation frequency in CLL. PLoS One. 2017 Jan 26;12(1):e0167602. https://doi.org/10.1371/journal.pone.0167602
  • Catera R, Liu Y, Gao C, Yan X-J, Magli A, Allen SL, Kolitz JE, Rai KR, Chu CC, Feizi T, Stamatopoulos K, Chiorazzi N. Binding of CLL subset 4 B-cell receptor immunoglobulins to viable human memory B lymphocytes requires a distinctive IGKV somatic mutation. Mol Med. 2017 Mar;23:1-12. Epub 2017 Jan 12. https://doi.org/10.2119/molmed.2017.00003
  • Fabbri G, Holmes AB, Viganotti M, Scuoppo C, Belver L, Herranz D, Yan XJ, Kieso Y, Rossi D, Gaidano G, Chiorazzi N, Ferrando AA, Dalla-Favera R. Common nonmutational NOTCH1 activation in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2911-E2919. Epub 2017 Mar 17. https://doi.org/10.1073/pnas.1702564114
  • Herndon T, Chen S-S, Saba N, Valdez J, Emson C, Gatmaitan M, Tian X, Hughes T, Sun C, Arthur D, Stetler-Stevenson M, Yuan C, Niemann C, Marti G, Aue G, Soto S, Farooqui M, Herman S, Chiorazzi N, Wiestner A. Direct in vivo evidence for increased proliferation of CLL cells in lymph nodes compared to bone marrow and peripheral blood. Leukemia. 2017 Jun;31(6):1340-1347. Epub 2017 Jan 11. https://doi.org/10.1038/leu.2017.11
  • Murphy EJ, Neuberg DS, Rassenti LZ, Hayes Greg, Redd R, Emson C, Li K, McConnel C, Greaves A, Turner S, Brown J, Weirda W, Byrd J, Zent C, Kay N, Barrientos J, Hellerstein M, Chiorazzi N, Kipps TJ, Rai KR. Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia. Leukemia. 2017 Jun;31(6):1348-1354. Epub 2017 Jan 24. https://doi.org/10.1038/leu.2017.34
  • Minici C, Gounari M, Übelhart R, Scarfò L, Dühren-von Minden M, Schneider D, Tasdogan A, Alkhatib A, Agathangelidis A, Ntoufa S, Chiorazzi N, Jumaa H, Stamatopoulos K, Ghia P, Degano M. Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukemia. Nat Commun. 2017 Jun 9;8:15746. https://doi.org/10.1038/ncomms15746
  • Young E, Noerenberg D, Mansouri L, Ljungström V, Frick M, Sutton L-A, Blakemore S, Galan-Sousa J, Plevova K, Baliakas P, Rossi D, Clifford R, Roos-Weil D, Navrkalova V, Dörken B, Schmitt C, Ekstrom Smedby K, Juliusson G, Giacopelli B, Blachly J, Belessi C, Chiorazzi N, Panayiotidis P, Davi F, Langerak A, Oscier D, Schuh A, Gaidano G, Ghia P, Xu W, Fan L, Bernard O, N’Guyen Khac F, Rassenti L, Li J, Kipps T, Stamatopoulos K, Pospisilova S, Zenz T, Oakes C, Strefford J, Rosenquist R, Damm F. EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia. Leukemia. 2017 Jul;31(7):1547-1554. Epub 2016 Nov 28. https://doi.org/10.1038/leu.2016.359
  • Xochelli A, Baliakas P, Kavakiotis I, Agathangelidis A, Sutton LA, Minga E, Ntoufa S, Tausch E, Yan XJ, Shanafelt TD, Plevova K, Boudjogra M, Rossi D, Davis Z, Navarro A, Sandberg Y, Vojdeman FJ, Scarfò L, Stavroyianni N, Sudarikov A, Veronese S, Tzenou T, Karan Djurasevic T, Catherwood MA, Kienle D, Chatzouli M, Facco M, Bahlo J, Pott C, Pedersen LB, Mansouri L, Smedby KE, Chu CC, Giudicelli V, Lefranc MP, Panagiotidis P, Juliusson G, Anagnostopoulos A, Vlahavas I, Antic D, Trentin L, Montillo M, Niemann CU, Dohner H, Langerak AW, Pospisilova S, Hallek M, Campo E, Chiorazzi N, Maglaveras N, Oscier D, Gaidano G, Jelinek DF, Stilgenbauer S, Chouvarda I, Darzentas N, Belessi C, Davi F, Hadzidimitriou A, Rosenquist R, Ghia P, Stamatopoulos K. Chronic lymphocytic leukemia with mutated IGHV4-34 receptors: shared and distinct immunogenetic features and clinical outcomes. Clin Cancer Res. 2017 Sep 1;23(17):5292-5301. Epub 2017 May 23. https://doi.org/10.1158/1078-0432.CCR-16-3100
  • Vergani S, Korsunsky I, Mazzarello AN, Ferrer G, Chiorazzi N, Bagnara D. Novel method for high-throughput full-length sequencing of the immune repertoire from bulk B cells with single-cell resolution. Front Immunol. 2017 Sep 14;8:1157. https://doi.org/10.3389/fimmu.2017.01157
  • Yigit B, Wang N, Chen S-S, Chiorazzi N, Terhorst C. Inhibition of reactive oxygen species limits expansion of chronic lymphocytic leukemia cells. Leukemia. 2017 Oct;31(10):2273-2276. Epub 2017 Jul 28. https://doi.org/10.1038/leu.2017.241
  • Niemann C, Mora-Jensen H, Dadashian E, Krantz F, Covey T, Chen S-S, Chiorazzi N, Izumi R, Ulrich R, Lannutti B, Wiestner A, Herman S. Combined BTK and PI3Kδ inhibition with acalabrutinib and ACP-319 improves survival and tumor control in CLL mouse models. Clin Cancer Res. 2017 Oct 1;23(19):5814-5823. Epub 2017 Jun 23. https://doi.org/10.1158/1078-0432.CCR-17-0650
  • Bosch R, Ferrer G, Damle R, Jansà S, Gorlatov S, Nomdedéu J, Martino R, Novelli S, Garrido A, Garcia I, Granell M, Rai K, Montserrat E, Sierra J, Chiorazzi N, Moreno C. FcγRIIb expression in early stage chronic lymphocytic leukemia. Leuk Lymphoma. 2017 Nov;58(11):2642-2648. Epub 2017 Apr 4. https://doi.org/10.1080/10428194.2017.1307981

2018

  • Baliakas P, Mattsson M, Hadzidimitriou A, Minga E, Agathangelidis A, Sutton LA, Scarfo L, Davis Z, Yan XJ, Plevova K, Sandberg Y, Vojdeman FJ, Tzenou T, Chu CC, Veronese S, Mansouri L, Smedby KE, Giudicelli V, Nguyen-Khac F, Panagiotidis P, Juliusson G, Anagnostopoulos A, Lefranc MP, Trentin L, Catherwood M, Montillo M, Niemann CU, Langerak AW, Pospisilova S, Stavroyianni N, Chiorazzi N, Oscier D, Jelinek DF, Shanafelt T, Darzentas N, Belessi C, Davi F, Ghia P, Rosenquist R, Stamatopoulos K. No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy. Haematologica. 2018 Apr;103(4):e158-e161. Epub 2017 Dec 21. https://doi.org/10.3324/haematol.2017.182634
  • Marsilio S, KhiabanianH, Fabbri G, Vergani S, Scuoppo C, Montserrat E, Shpall EJ, Hadigol M, Marin P, Rai KR, Rabadan R, Devereux S, Pasqualucci L, Chiorazzi N. Somatic CLL mutations occur at multiple distinct hematopoietic maturation stages: documentation and cautionary note regarding cell fraction purity. Leukemia. 2018 Apr;32(4):1041-1044. Epub 2017 Dec 5. https://doi.org/10.1038/leu.2017.343
  • Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O’Brien S, Robak T, Seymour J, Kipps TK. iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood. 2018 Jun 21;131(25):2745-2760. Epub 2018 Mar 14. https://doi.org/10.1182/blood-2017-09-806398
  • Rabadan R, Bhanot G, Marsilio S, Chiorazzi N, Pasqualucci L, Khiabanian H. On statistical modeling of sequencing noise in high depth data to assess tumor evolution. J Stat Phys. 2018 Jul;172(1):143-155. Epub 2017 Dec 21. https://doi.org/10.1007/s10955-017-1945-1
  • Gupta R, Yan XJ, Barrientos J, Kolitz JE, Allen SL, Rai K, Chiorazzi N, Mongini PKA. Mechanistic insights into CpG DNA and IL-15 synergy in promoting B cell chronic lymphocytic leukemia clonal expansion. J Immunol. 2018 Sep 1;201(5):1570-1585. Epub 2018 Aug 1. https://doi.org/10.4049/jimmunol.1800591
  • Polychronidou E, Kalamaras E, Agathangelidis A, Sutton L-A, Yan X-J, Bikos V, Vardi A, Mochament K, Chiorazzi N, Belessi C, Rosenquist R, Ghia P, Stamatopoulos K, Vlamos P, Chailyan A, Overby N, Marcatili P, Hadzidimitriou A, Tzovaras D. Automated shape-based clustering of 3D immunoglobulin protein structures in chronic lymphocytic leukemia. BMC Bioinformatics. 2018 Nov 20;19(Suppl 14):414. https://doi.org/10.1186/s12859-018-2381-1

2019

  • Mazzarello AN, Fitch M, Hellerstein MK, Chiorazzi N. Measurement of leukemic B cell growth kinetics in patients with chronic lymphocytic leukemia. Methods Mol Biol. 2019;1881:129-151. https://doi.org/10.1007/978-1-4939-8876-1_11
  • Qi J, Chen S-S, Chiorazzi N, Rader C. An IgG1-like bispecific antibody targeting CD52 and CD20 for the treatment of B cell malignancies. Methods. 2019 Feb 1;154:70-76. Epub 2018 Aug 24. https://doi.org/10.1016/j.ymeth.2018.08.008
  • Van Roosbroeck K, Bayraktar R, Calin S, Bloehdorn J, Dragomir M, Okubo K, Bertilaccio MT, Zupo S, You MJ, Gaidano G, Rossi D, Chen S-S, Chiorazzi N, Thompson P, Ferrajoli A, Bertoni F, Stilgenbauer S, Keating M, Calin G. The involvement of microRNA in the pathogenesis of Richter syndrome. Haematologica. 2019 May;104(5):1004-1015. Epub 2018 Nov 8. https://doi.org/10.3324/haematol.2018.203828
  • Gupta R, Li W, Yan XJ, Barrientos J, Kolitz JE, Allen SL, Rai K, Chiorazzi N, Mongini PK. Mechanism for IL-15–Driven B Cell Chronic Lymphocytic Leukemia Cycling: Roles for AKT and STAT5 in Modulating Cyclin D2 and DNA Damage Response Proteins. J Immunol. 2019 May 15;202(10):2924-2944. Epub 2019 Apr 15. https://doi.org/10.4049/jimmunol.1801142
  • Shea LK, Honjo K, Redden DT, Tabengwa E, Li R, Li FJ, Shakhmatov M, Chiorazzi N, Davis RS. Fc receptor-like 2 (FCRL2) is a novel marker of low-risk CLL and refines prognostication based on IGHV mutation status. Blood Cancer J. 2019 May 15;9(6):47. https://doi.org/10.1038/s41408-019-0207-7
  • Scheffold A, Jebaraj BM, Tausch E, Bloehdorn J, Ghia P, Yahiaoui A, Dolnik A, Blätte TJ, Bullinger L, Dheenadayalan RP, Li L, Schneider C, Chen, SS, Chiorazzi N, Dietrich S, Seiffert M, Tannheimer S, Döhner H, Mertens D, Stigenbauer S. IGF1R as druggable target mediating PI3K-δ inhibitor resistance in a murine model of chronic lymphocytic leukemia. Blood. 2019 Aug 8;134(6):534-547. Epub 2019 Apr 22. https://doi.org/10.1182/blood.2018881029
  • Yigit B, Wang N, Ten Hacken E, Chen SS, Bhan AK, Suarez-Fueyo A, Katsuyama E, Tsokos GC, Chiorazzi N, Wu CJ, Burger JA, Herzog RW, Engel P, Terhorst C. SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer. Cancer Immunol Res. 2019 Sep;7(9):1485-1496. Epub 2019 Jul 17. https://doi.org/10.1158/2326-6066.CIR-18-0664

2020

  • Chiorazzi N, Stevenson FK. Celebrating 20 Years of IGHV Mutation Analysis in CLL. Hemasphere. 2020 Jan 22;4(1):e334. eCollection 2020 Feb. https://doi.org/10.1097/HS9.0000000000000334
  • Maity PC, Bilal M, Koning MT, Young M, van Bergen CAM, Renna V, Nicolò A, Datta M, Gentner-Göbel E, Barendse RS, Somers SF, de Groen RAL, Vermaat JSP, Steinbrecher D, Schneider C, Tausch E, Bittolo T, Bomben R, Mazzarello AN, Del Poeta G, Kroes WGM, van Wezel JT, Imkeller K, Busse CE, Degano M, Bakchoul T, Schulz AR, Mei H, Ghia P, Kotta K, Stamatopoulos K, Wardemann H, Zucchetto A, Chiorazzi N, Gattei V, Stilgenbauer S, Veelken H, Jumaa H. IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4320-4327. Epub 2020 Feb 11. https://doi.org/10.1073/pnas.1913810117
  • Bartholdy BA, Wang X, Yan XJ, Pascual M, Fan M, Barrientos J, Allen SL, Martinez-Climent JA, Rai KR, Chiorazzi N, Scharff MD, Roa S. CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation. Blood Adv. 2020 Mar 10;4(5):893-905. https://doi.org/10.1182/bloodadvances.2019000817
  • Bosch R, Mora A, Cuellar C, Ferrer G, Gorlatov S, Nomdedéu J, Montserrat E, Sierra J, Rai KR, Chiorazzi N, Moreno C. FcγRIIb-BCR Co-Ligation Inhibits BCR Signaling in Chronic Lymphocytic Leukemia. Haematologica. 2021 Jan 1; 106(1): 306-309. https://doi.org/10.3324/haematol.2019.245795
  • Moffitt AB, Spector MS, Andrews P, Kendall J, Alexander J, Stepansky A, Ma B, Kolitz J, Chiorazzi N, Allen SL, Krasnitz A, Wigler M, Levy D, Wang Z. Multiplex accurate sensitive quantitation (MASQ) with application to minimal residual disease in acute myeloid leukemia. Nucleic Acids Res. 2020 Apr 17;48(7):e40. https://doi.org/10.1093/nar/gkaa090
  • Tang C, Bagnara D, Chiorazzi N, Scharff MD, MacCarthy T. AID overlapping and Polη hotspots are key features of evolutionary variation within the human antibody heavy chain (IGHV) genes. Front Immunol. 2020 Apr 30;11:788. eCollection 2020. https://doi.org/10.3389/fimmu.2020.0078
  • Podaza E, Palacios F, Croci DO, Risnik D, Yan XJ, Almejún MB, Colado A, Elías EE, Borge M, Morande PE, Bezares R, Fernández-Grecco H, Rabinovich GA, Gamberale R, Chiorazzi N, Giordano M. Expression and function of cathelicidin hCAP18/LL-37 in chronic lymphocytic leukemia. Haematologica. 2021 Jan 1;105(9):e465-469. [2020 Sep 1]. https://doi.org/10.3324/haematol.2019.227975
  • Sivina M, Xiao L, Kim E, Vaca A, Chen SS, Keating MJ, Ferrajoli A, Estrov Z, Jain N, Wierda WG, Huang X, Chiorazzi N, Burger JA. CXCL13 plasma levels function as a biomarker for disease activity in patients with chronic lymphocytic leukemia. Leukemia. 2020 Oct 21. [Epub ahead of print] https://doi.org/10.1038/s41375-020-01063-

2021

  • Chiorazzi N, Chen SS, Rai KR. Chronic Lymphocytic Leukemia. Cold Spring Harb Perspect Med. 2021 Feb 1;11(2):a035220. https://doi.org/10.1101/cshperspect.a035220
  • Blanco G, Puiggros A, Sherry B, Nonell L, Calvo X, Puigdecanet E, Chiu PY, Kieso Y, Ferrer G, Palacios F, Arnal M, Rodríguez-Rivera M, Gimeno E, Abella E, Rai KR, Abrisqueta P, Bosch F, Calon A, Ferrer A, Chiorazzi N, Espinet B. CLL-like monoclonal B cell lymphocytosis displays an increased inflammatory signature that is reduced in early stage chronic lymphocytic leukemia. Exp Hematol. 2021 Mar;95:68-80. [Epub 2021 Jan 7] https://doi.org/10.1016/j.exphem.2020.12.007
  • Morande PE, Yan XJ, Sepulveda-Yanez JH, Seija N, Marquez ME, Sotelo NS, Abreu C, Crispo M, Fernández-Graña G, Rego N, Bois T, Methot SP, Palacios F, Remedi V, Rai KR, Buschiazzo A, Di Noia JM, Navarrete MA, Chiorazzi N, Oppezzo P. AID overexpression leads to aggressive murine CLL and non-Ig mutations that mirror human neoplasms. Blood. 2021 Mar 2:blood.2020008654. [Epub ahead of print] https://doi.org/10.1182/blood.2020008654.
  • Patten PEM, Ferrer G, Chen SS, Kolitz JE, Rai KR, Allen SL, Barrientos JC, Ioannou N, Ramsay AG, Chiorazzi N. A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice. Front Immunol. 2021 Mar 9;12:627020. https://doi.org/10.3389/fimmu.2021.627020.
  • Agathangelidis A, Chatzidimitriou A, Gemenetzi K, Giudicelli V, Karypidou M, Plevova K, Davis Z, Yan XJ, Jeromin S, Schneider C, Pedersen LB, Tschumper RC, Sutton LA, Baliakas P, Scarfò L, van Gastel EJ, Armand M, Tausch E, Biderman B, Baer C, Bagnara D, Navarro A, Langlois de Septenville A, Guido V, Mitterbauer-Hohendanner G, Dimovski A, Brieghel C, Lawless S, Meggendorfer M, Brazdilova K, Ritgen M, Facco M, Tresoldi C, Visentin A, Patriarca A, Catherwood M, Bonello L, Sudarikov A, Vanura K, Roumelioti M, Skuhrova Francova H, Moysiadis T, Veronese S, Giannopoulos K, Mansouri L, Karan-Djurasevic T, Sandaltzopoulos R, Bödör C, Fais F, Kater A, Panovska I, Rossi D, Alshemmari S, Panagiotidis P, Costeas P, Espinet B, Antic D, Foroni L, Montillo M, Trentin L, Stavroyianni N, Gaidano G, Francia di Celle P, Niemann C, Campo E, Anagnostopoulos A, Pott C, Fischer K, Hallek M, Oscier D, Stilgenbauer S, Haferlach C, Jelinek D, Chiorazzi N, Pospisilova S, Lefranc MP, Kossida S, Langerak AW, Belessi C, Davi F, Rosenquist R, Ghia P, Stamatopoulos K. Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL. Blood. 2021 Mar 11;137(10):1365-1376. https://doi.org/10.1182/blood.2020007039.
  • Palacios F, Yan XJ, Ferrer G, Chen SS, Vergani S, Yang X, Gardner J, Barrientos JC, Rock P, Burack R, Kolitz JE, Allen SL, Kharas MG, Abdel-Wahab O, Rai KR, Chiorazzi N. Musashi 2 influences chronic lymphocytic leukemia cell survival and growth making it a potential therapeutic target. Leukemia. 2021 Apr;35(4):1037-1052. [Epub 2021 Jan 27]. https://doi.org/10.1038/s41375-020-01115-y.
  • Ferrer G, Jung B, Chiu PY, Aslam R, Palacios F, Mazzarello AN, Vergani S, Bagnara D, Chen SS, Yancopoulos S, Xochelli A, Yan XJ, Burger JA, Barrientos JC, Kolitz JE, Allen SL, Stamatopoulos K, Rai KR, Sherry B, Chiorazzi N. Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL. Leukemia. 2021 May 2. https://doi.org/10.1038/s41375-021-01249-7. [Epub ahead of print].
  • Oppezzo P, Navarrete M, Chiorazzi N. AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression. Front Oncol. 2021 May 10;11:634383. https://doi.org/ 10.3389/fonc.2021.634383.

Page last updated on June 03, 2021.

%d bloggers like this: