Collected Works of Guillermo Dighiero

Introduction

Photo of Guillermo Dighiero

Dr. Guillermo Dighiero is best known for his work in the French CLL trials and for his insight into the biology of the CLL BCR repertoire before it was widely appreciated. He was the first to quantify the low levels of surface immunoglobulin on the CLL lymphocyte compared to normal B cells. He was involved in the initial Binet clinical staging system based on multivariant survival analysis. The analysis of the B cell repertoire in fetal liver, cord blood and CLL patients led to the early recognition of skewed distributions of mutated and unmutated Ig subsets.

Dr. Dighiero received his medical degree from the University of Montevideo in 1969, and received his PhD from the University of Paris in 1978. For some time, he was the Top Degree Research Director at the Centre National de la Recherche Scientifique (CNRS) and head of the Department of Physiopathology at the Institut Pasteur in Paris. Currently, he is the head of the Pasteur Institute of Montevideo and the Ambassador of Uruguay to France.

Collected Works

1974

  • Ternynck T, Dighiero G, Follezou J, Binet JL. Comparison of normal and CLL lymphocyte surface Ig determinants using peroxidase-labeled antibodies. I. Detection and quantitation of light chain determinants. Blood. 1974 Jun;43(6):789-95. https://doi.org/10.1182/blood.V43.6.789.789

1975

  • Binet JL, Dighiero G, D’Athis P, Feinermann M, de Montaut F, Seroude J. Volumetric determinations of blood cells in acute lymphoblastic leukemia. In Bessis M, Brecher G, Eds. Unclassifiable Leukemias. Berlin, Germany: Springer; 1975:95-97. https://doi.org/10.1007/978-3-642-66126-6_14

1976

  • Dighiero G, Follezou JY, Roisin JP, Ternynck T, Binet JL. Comparison of normal and chronic lymphocytic leukemia lymphocyte surface Ig determinants using peroxidase-labeled antibodies. II. quantification of light chain determinants in atypical lymphocytic leukemia. Blood. 1976 Oct;48(4):559-66. https://doi.org/10.1182/blood.V48.4.559.559

1977

  • Dighiero G, Follezou JY, Roisin JP, Charron D, Bouvet E, Ternyck T, Binet JL. Intérêt de la quantification des immunoglobulines de surface dans les syndromes lympho-prolifératifs. Nouv Rev Fr Hematol Blood Cells. 1977;18(1):180-1.
  • Binet JL, Nizet MG, Dighiero G, Grellet J. La lymphographie dans la leucémie lymphoïde chronique. Nouv Rev Fr Hematol Blood Cells. 1977;18(2):351-63.
  • Dighiero G, Vaugier G, Charron D, d’Athis P, Binet JL. Variations in lymphocyte counts four hours after administration of hydrocortisone in patients with chronic lymphocytic leukemia. Blood. 1977 May;49(5):719-28. https://doi.org/10.1182/blood.V49.5.719.719
  • Dighiero G, Follezou JY, Binet JL. Surface immunoglobulins in lymphocytic leukemias. Blood. 1977 Jul;50(1):179. https://doi.org/10.1182/blood.V50.1.179.179
  • Binet JL, Leporrier M, Dighiero G, Charron D, D’Athis P, Vaugier G, Beral HM, Natali JC, Raphael M, Nizet B, Follezou JY. A clinical staging system for chronic lymphocytic leukemia: prognostic significance. Cancer. 1977 Aug;40(2):855-64. https://doi.org/10.1002/1097-0142(197708)40:2%3C855::aid-cncr2820400239%3E3.0.co;2-1
  • Follezou JY, Dighiero G, Roisin JP, Ternynck T, Binet JL. Contribution of quantitative immunocytology to the study of lymphoid hemopathies. Biomedicine. 1977 Oct;26(5):330-6.
  • Charron D, Dighiero G, Raphael M, Binet JL. Bone-marrow patterns and clinical staging in chronic lymphocyte leukaemia. Lancet. 1977 Oct 15;2(8042):819. https://doi.org/10.1016/S0140-6736(77)90751-6
  • Binet JL, Vaugier G, Dighiero G, d’Athis P, Charron D. Investigation of a new parameter in chronic lymphocytic leukemia: the percentage of large peripheral lymphocytes determined by the Hemalog D. Prognostic significance. Am J Med. 1977 Nov;63(5):683-8. https://doi.org/10.1016/0002-9343(77)90152-8

1978

  • Follezou JY, Dighiero G, Roisin JP, Binet JL. Ontogeny of B lymphocytes in mice. Quantification of surface membrane immunoglobulins by immunoperoxidase assay. Immunology. 1978 Apr;34(4):733-9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1457174/
  • Dighiero G, Karsenti E, Follezou JY, Bornens M. Visualization of tubulin in lymphocytes. I. Comparison of normal and chronic lymphocytic leukemia (CLL) lymphocytes. Blood. 1978 Jun;51(6):1031-7. https://doi.org/10.1182/blood.V51.6.1031.1031
  • Vaugier G, Dighiero G, Charron D, Natali JC, Leporrier M, Debré P, d’Athis P, Binet JL. Nouveau paramètre dans la leucémie lymphoïde chronique: Les grands lymphocytes du sang determines par l’Hemalog D. Nouv Rev Fr Hematol. 1978 Jun 10;20(2):311-5.
  • Dighiero G, Charron D, Vaugier G, Leporrier M, Debré P, d’Athis P, Binet JL. Étude comparative du nombre des lymphocytes sanguins chez le sujet normal et dans la leucémie lymphoïde chronique 4 heures après l’injection d’hydrocortisone. Nouv Rev Fr Hematol. 1978 Jun 10;20(2):317-22.

1979

  • Dighiero G. Les marqueurs de membrane des lymphocytes dans la leucemie lymphoide chronique. Nouv Rev Fr Hematol. 1979;Suppl:VII-IX.
  • Dighiero G, Binet JL. Apports des nouvelles méthodes de cytologie et d’immunologie quantitative à la comprehension des syndromes lymphoprolifératifs. C R Seances Soc Biol Fil. 1979;173(2):213-20.
  • Dighiero G, Charron D, Debre P, Le Porrier M, Vaugier G, Follezou JY, Degos L, Jacquillat C, Binet JL. Identification of a pure splenic form of chronic lymphocytic leukaemia. Br J Haematol. 1979 Feb;41(2):169-76. https://doi.org/10.1111/j.1365-2141.1979.tb05845.x
  • Chenal C, Binet JL, Dighiero G, Leporrier M, Debré P, Merle Béral H, Cayre Y, Guérin RA. Total body irradiation in eight cases of advanced chronic lymphocytic leukamia. Biomedicine. 1979 Apr;31(2):31-2.
  • Leporrier M, Dighiero G, Auzemery M, Binet JL. Detection and quantification of platelet-bound antibodies with immunoperoxidase. Br J Haematol. 1979 Aug;42(4):605-11. https://doi.org/10.1111/j.1365-2141.1979.tb01173.x
  • Grellet J, Curet P, Laemmel MG, Cazala P, Dighiero G, Binet JL. Correlation between lymphographic grouping and anatomic and clinical stages in chronic lymphoid leukemia. AJR Am J Roentgenol. 1979 Nov;133(5):797-803. https://doi.org/10.2214/ajr.133.5.797

1980

  • Dighiero G, Lesty C, Couty MC, Binet JL. Valeur pronostique de l’étude des volumes lymphocytaires dans la leucémie lymphoïde chronique. Nouv Rev Fr Hematol. 1980;22(4):383-90.
  • Dighiero G, Lesty C, Leporrier M, Couty MC. Computer analysis of platelet volumes. Blood Cells. 1980;6(3):365-70.
  • Dighiero G, Bodega E, Mayzner R, Binet JL. Two new applications of the immunoperoxidase method: cell-by-cell quantitation of surface immunoglobulins and automated recognition of B-lymphocytes. Blood Cells. 1980;6(3):371-9.
  • Dighiero G, Bodega E, Mayzner R, Binet JL. Individual cell-by-cell quantitation of lymphocyte surface membrane Ig in normal and CLL lymphocyte and during ontogeny of mouse B lymphocytes by immunoperoxidase assay. Blood. 1980 Jan;55(1):93-100. https://doi.org/10.1182/blood.V55.1.93.93

1981

  • Dighiero G, Bodega E, Binet JL. Differentiation ability of the CLL lymphocyte: an immature lymphocyte or an abnormal leukemic cell? Blood Cells. 1981;7(2):331-9.
  • Avrameas S, Guilbert B, Dighiero G. Natural antibodies against tubulin, actin myoglobin, thyroglobulin, fetuin, albumin and transferrin are present in normal human sera, and monoclonal immunoglobulins from multiple myeloma and Waldenström’s macroglobulinemia may express similar antibody specificities. Ann Immunol (Paris). 1981 Mar-Apr;132C(2):231-6. https://doi.org/10.1016/0769-2625(81)90031-3
  • Binet JL, Catovsky D, Chandra P, Dighiero G, Montserrat E, Rai KR, Sawitsky A. Chronic lymphocytic leukaemia: Proposals for a revised prognostic staging system. Br J Haematol. 1981 Jul; 48(3):365-367. https://doi.org/10.1111/j.1365-2141.1981.tb02727.x
  • Binet JL, Auquier A, Dighiero G, Chastang C, Piguet H, Goasguen J, Vaugier G, Potron G, Colona P, Oberling F, Thomas M, Tchernia G, Jacquillat C, Boivin P, Lesty C, Duault MT, Monconduit M, Belabbes S, Gremy F. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer. 1981 Jul 1;48(1):198-206. https://doi.org/10.1002/1097-0142(19810701)48:1%3C198::AID-CNCR2820480131%3E3.0.CO;2-V

1982

  • Dighiero G, Mayzner R, Roisin JP, Binet JL. Automated recognition of B and T lymphocytes by immunoperoxidase on the hemalog D system and its applications. Blood Cells. 1982;8(2):447-54.
  • Guilbert B, Dighiero G, Avrameas S. Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization. J Immunol. 1982 Jun;128(6):2779-87. https://www.jimmunol.org/content/128/6/2779.long
  • Dighiero G, Guilbert B, Avrameas S. Naturally occurring antibodies against nine common antigens in humans sera. II. High incidence of monoclonal Ig exhibiting antibody activity against actin and tubulin and sharing antibody specificities with natural antibodies. J Immunol. 1982 Jun;128(6):2788-92. https://www.jimmunol.org/content/128/6/2788.long

1983

  • Avrameas S, Dighiero G, Lymberi P, Guilbert B. Studies on natural antibodies and autoantibodies. Ann Immunol (Paris). 1983 Jul-Aug;134D(1):103-13. https://doi.org/10.1016/S0769-2625(83)80061-0
  • Dighiero G, Guilbert B, Fermand JP, Lymberi P, Danon F, Avrameas S. Thirty-six human monoclonal immunoglobulins with antibody activity against cytoskeleton proteins, thyroglobulin, and native DNA: immunologic studies and clinical correlations. Blood. 1983 Aug;62(2):264-70. https://doi.org/10.1182/blood.V62.2.264.bloodjournal622264
  • Dighiero G, Lymberi P, Mazié JC, Rouyre S, Butler-Browne GS, Whalen RG, Avrameas S. Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens. J Immunol. 1983 Nov;131(5):2267-72. https://www.jimmunol.org/content/131/5/2267.long

1984

  • Dighiero G, Bodega E, Binet JL. New trends on lymphocyte differentiation in B-CLL. Nouv Rev Fr Hematol. 1984;26:89.

1985

1986

  • Binet JL, Travade P, Chastang C, Dighiero G, Merle-Béral H, Raphael M. Aspects biologiques de la leucémie lymphoïde chronique. C R Seances Soc Biol Fil. 1986;180(5):503-11.
  • Karsenty G, Timsit J, Casadevall N, Dighiero G, Tulliez M, Mathiot C, Thomsen M, Joly J, Luton JP. Thyroïdite d’Hashimoto avec production intra-thyroïdienne d’un autoanticorps monoclonal antithyroglobuline. Ann Endocrinol (Paris). 1986;47(5):395-8.
  • Dighiero G, Lymberi P, Guilbert B, Ternynck T, Avrameas S. Natural autoantibodies constitute a substantial part of normal circulating immunoglobulins. Ann N Y Acad Sci. 1986;475:135-45. https://doi.org/10.1111/j.1749-6632.1986.tb20863.x
  • Dighiero G, Poncet P, Rouyre S, Mazie JC. Newborn Xid mice carry the genetic information for the production of natural autoantibodies against DNA, cytoskeletal proteins, and TNP. J Immunol. 1986 Jun 1;136(11):4000-5. https://www.jimmunol.org/content/136/11/4000.long
  • French Cooperative Group on Chronic Lymphocytic Leukaemia. Effectiveness of “CHOP” regimen in advanced untreated chronic lymphocytic leukaemia. French Cooperative Group on Chronic Lymphocytic Leukaemia. Lancet. 1986 Jun 14;1(8494):1346-9. https://doi.org/10.1016/S0140-6736(86)91663-6
  • Chastang C, Travade P, Benichou J, Dighiero G, Binet JL. Patient accrual and interim statistical analysis in long-term randomized clinical trials: the French chronic lymphocytic leukemia CLL 80 protocol as a case study. Stat Med. 1986 Sep-Oct;5(5):465-73. https://doi.org/10.1002/sim.4780050511

1987

  • Dighiero G, Binet JL. Does B-CLL correspond to expansion of an immature B-cell clone, or to expansion of a distinct B-cell sublineage?. In Rai KR, Gale RP, eds. Chronic Lymphocytic Leukemia: Recent Progress and Future Direction. UCLA Symposium on Molecular and Cellular Biology, New Series, vol. 59. New York, NY: Alan R. Liss; 1987: 215-224.
  • Dighiero G, Binet JL. Does the CLL B lymphocyte correspond to expansion of an immature B clone or to expansion of a distinct subpopulation of B cells? Blood Cells. 1987;12(2):385-97.
  • Dighiero G, Kaushik A, Poncet P, Ge XR. Origin and significance of autoantibodies. Concepts Immunopathol. 1987;4:42-76.
  • Dighiero G, Poncet P, Matthes T, Kaushik A. Is autoantibody production related to particular B-cell subsets and variable region genes? Pathol Immunopathol Res. 1987;6(5-6):371-89. https://doi.org/10.1159/000157064
  • Travade P, Chastang C, Dighiero G, Binet JL. New trends in CLL treatment. Blood Cells. 1987;12(2):485-502.
  • Dighiero G. Relevance of murine models in elucidating the origin of B-CLL lymphocytes and related immune-associated phenomena. Semin Hematol. 1987 Oct;24(4):240-51.
  • Dighiero G, Intrator L, Cordonnier C, Tortevoye P, Vernant JP. High levels of anti-cytoskeleton autoantibodies are frequently associated with chronic GVHD. Br J Haematol. 1987 Nov;67(3):301-5. https://doi.org/10.1111/j.1365-2141.1987.00301.x
  • Dighiero G, Lim A, Poncet P, Kaushik A, Ge XR, Mazié JC. Age-related natural antibody specificities among hybridoma clones originating from NZB spleen. Immunology. 1987 Nov;62(3):341-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1454123/
  • Dighiero G, Magnac C, de Saint Martin J, Abuaf N. Detection of anti-mitochondrial antibodies by ELISA and Western-blot techniques and identification by one and two-dimensional gel electrophoresis of M2 target antigens. Clin Exp Immunol. 1987 Dec;70(3):640-8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1542188/

1988

  • Dighiero G. An attempt to explain disordered immunity and hypogammaglobulinemia in B-CLL. Nouv Rev Fr Hematol. 1988;30(5-6):283-8.
  • Vuillier F, Tortevoye P, Binet JL, Dighiero G. CD4, CD8 and NK subsets in B-CLL. Nouv Rev Fr Hematol. 1988;30(5-6):331-4.
  • French Cooperative Group on Chronic Lymphocytic Leukaemia. Comparison of the (A, B, C) staging and the Rai’s staging from a large prospective series (935 patients). French Cooperative Group on Chronic Lymphocytic Leukemia. Nouv Rev Fr Hematol. 1988;30(5-6):363-7.
  • Kaushik A, Matthes T, Dighiero G. Do natural autoantibodies play an important role in the elimination of senescent or damaged red blood cells? Blood Cells. 1988;14(1):161-74.
  • Matthes T, Dighiero G. Detection of private and recurrent idiotopes on natural anti-tubulin antibodies by monoclonal anti-idiotopic antibodies. J Immunol. 1988 Jan 1;140(1):148-54. https://www.jimmunol.org/content/140/1/148.long
  • Vuillier F, Lapresle C, Dighiero G. Comparative analysis of CD4-4B4 and CD4-2H4 lymphocyte subpopulations in HIV negative homosexual, HIV seropositive and healthy subjects. Clin Exp Immunol. 1988 Jan;71(1):8-12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541654/
  • Kaushik A, Lim A, Poncet P, Ge XR, Dighiero G. Comparative analysis of natural antibody specificities among hybridomas originating from spleen and peritoneal cavity of adult NZB and BALB/c mice. Scand J Immunol. 1988 Apr;27(4):461-71. https://doi.org/10.1111/j.1365-3083.1988.tb02372.x
  • Vuillier F, Bianco NE, Montagnier L, Dighiero G. Selective depletion of low-density CD8+, CD16+ lymphocytes during HIV infection. AIDS Res Hum Retroviruses. 1988 Apr;4(2):121-9. https://doi.org/10.1089/aid.1988.4.121
  • Poncet P, Matthes T, Billecocq A, Dighiero G. Immunochemical studies of polyspecific natural autoantibodies: charge, lipid reactivity, Fab’2 fragments activity and complement fixation. Mol Immunol. 1988 Oct;25(10):981-9. https://doi.org/10.1016/0161-5890(88)90004-1
  • Matthes T, Wolff A, Soubiran P, Gros F, Dighiero G. Antitubulin antibodies. II. Natural autoantibodies and induced antibodies recognize different epitopes on the tubulin molecule. J Immunol. 1988 Nov 1;141(9):3135-41. https://www.jimmunol.org/content/141/9/3135.long
  • Dighiero G, Lim A, Lembezat MP, Kaushik A, Andrade L, Freitas A. Comparative study of VH gene family usage by newborn xid and non-xid mice, newborn NZB and adult NZB mice, and by splenic and peritoneal cavity B cell compartments. Eur J Immunol. 1988 Dec;18(12):1979-83. https://doi.org/10.1002/eji.1830181217

1989

  • Gale RP, Binet JL, Catovsky D, Dighiero G, Montserrat E, Rai KR, Rozman C, Sawitsky A. 4th International Workshop on CLL. Leuk Res. 1989;13(6):505-510. https://doi.org/10.1016/0145-2126(89)90173-2
  • Goshen E, Livne A, Krupp M, Hammarström L, Dighiero G, Slor H, Shoenfeld Y. Antinuclear and related autoantibodies in sera of healthy subjects with IgA deficiency. J Autoimmun. 1989 Feb;2(1):51-60. https://doi.org/10.1016/0896-8411(89)90107-8
  • Binet JL, Catovsky D, Dighiero G, Gale RP, Montserrat E, Rai KR, Rozman C, Sawitsky A. Chronic lymphocytic leukemia: recommendations for diagnosis, staging, and response criteria. Ann Intern Med. 1989 Feb 1;110(3):236-238. https://doi.org/10.7326/0003-4819-110-3-236
  • Poncet P, Reininger L, Freitas A, Holmberg D, Dighiero G, Coutinho A. Expression of VH11-gene family in hybridoma collections from peritoneum and spleen: differential correlation with BrMRBC reactivity. Res Immunol. 1989 Mar-Apr;140(3):255-64.
  • Binet JL, Catovsky D, Chastang C, Dighiero G, Fooks J, Galton DAG, Gates A, Hamblin TJ, Han T, Hansen MM, Keating MJ, Montserrat E, Pangalis GA, Polliack A, Rai KR, Richards S, International Workshop on CLL. Prognostic features of early chronic lymphocytic leukaemia. Lancet. 1989 Oct 21;334(8669):968-969. https://doi.org/10.1016/S0140-6736(89)90967-7
  • French Cooperative Group on Chronic Lymphocytic Leukaemia. Long-term results of the CHOP regimen in stage C chronic lymphocytic leukaemia. French Cooperative Group on Chronic Lymphocytic Leukaemia. Br J Haematol. 1989 Nov;73(3):334-40. https://doi.org/10.1111/j.1365-2141.1989.tb07749.x

1990

  • Dighiero G, Borche L. Evidence that the B lymphocyte proliferating in B-CLL and in other B-cell malignancies is frequently committed to production of natural autoantibodies. Nouv Rev Fr Hematol. 1990;32(5):323-6.
  • French Cooperative Group on Chronic Lymphocytic Leukemia. A randomized clinical trial of chlorambucil versus COP in stage B chronic lymphocytic leukemia. The French Cooperative Group on Chronic Lymphocytic Leukemia. Blood. 1990 Apr 1;75(7):1422-5. https://doi.org/10.1182/blood.V75.7.1422.bloodjournal7571422
  • Mayer R, Logtenberg T, Strauchen J, Dimitriu-Bona A, Mayer L, Mechanic S, Chiorazzi N, Borche L, Dighiero G, Mannheimer-Lory A, Diamond B, Alt F, Bona C. CD5 and immunoglobulin V gene expression in B-cell lymphomas and chronic lymphocytic leukemia. Blood. 1990 Apr 1;75(7):1518-24. https://doi.org/10.1182/blood.V75.7.1518.1518
  • Mesri EA, Levitus G, Hontebeyrie-Joskowicz M, Dighiero G, Van Regenmortel MH, Levin MJ. Major Trypanosoma cruzi antigenic determinant in Chagas’ heart disease shares homology with the systemic lupus erythematosus ribosomal P protein epitope. J Clin Microbiol. 1990 Jun;28(6):1219-24. https://jcm.asm.org/content/28/6/1219.long
  • Borche L, Lim A, Binet JL, Dighiero G. Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies. Blood. 1990 Aug 1;76(3):562-9. https://doi.org/10.1182/blood.V76.3.562.bloodjournal763562
  • French Cooperative Group on Chronic Lymphocytic Leukaemia. Natural history of stage A chronic lymphocytic leukaemia untreated patients. French Cooperative Group on Chronic Lymphocytic Leukaemia. Br J Haematol. 1990 Sep;76(1):45-57. https://doi.org/10.1111/j.1365-2141.1990.tb07835.x
  • Cayota A, Vuillier F, Scott-Algara D, Dighiero G. Preferential replication of HIV-1 in memory CD4+ subpopulation. Lancet. 1990 Oct 13;336(8720):941. https://doi.org/10.5555/uri:pii:0140673690923115
  • Dighiero G, Lymberi P, Monot C, Abuaf N. Sera with high levels of anti-smooth muscle and anti-mitochondrial antibodies frequently bind to cytoskeleton proteins. Clin Exp Immunol. 1990 Oct;82(1):52-6. https://doi.org/10.1111/j.1365-2249.1990.tb05402.x
  • Kaushik A, Mayer R, Fidanza V, Zaghouani H, Lim A, Bona C, Dighiero G. Ly1 and V-gene expression among hybridomas secreting natural autoantibody. J Autoimmun. 1990 Dec;3(6):687-700. https://doi.org/10.1016/S0896-8411(05)80036-8
  • Magnac C, de Saint Martin J, Pidard D, Legrand C, Dighiero G. Platelet antibodies in serum of patients with human immunodeficiency virus (HIV) infection. AIDS Res Hum Retroviruses. 1990 Dec;6(12):1443-9. https://doi.org/10.1089/aid.1990.6.1443

1991

  • Dighiero G. Autoreactive B-cell repertoire. Immunol Ser. 1991;55:39-60.
  • Dighiero G. Postulates defining pathogenic autoantibodies and T cells. Autoimmunity. 1991;10(3):257-8. https://doi.org/10.3109/08916939109001897
  • Dighiero G, Borche L. B Cell Malignancies Frequently Target the Autoreactive B Cell Repertoire. Leuk Lymphoma. 1991;5(Suppl 1):47-51. https://doi.org/10.3109/10428199109103378
  • Kourtis A, Pangalis GA, Borche L, Boussiotis VA, Dighiero G, Lymberi P. Monoclonal and/or Oligoclonal Immunoglobulins in Sera of Patients with Non-Hodgkin’s Lymphomas, Determined by Iso-Electric Focusing and Immunoblotting. Leuk Lymphoma. 1991;5(4):255-62. https://doi.org/10.3109/10428199109068135
  • Vuillier F, Scott-Algara D, Dighiero G. Extensive analysis of lymphocyte subsets in normal subjects by three-color immunofluorescence. Nouv Rev Fr Hematol. 1991;33(1):31-8.
  • Scott-Algara D, Vuillier F, Dauguet C, Dighiero G. Establishment of long term cell lines from 2 patients with large granular lymphocyte lymphocytosis displaying an unusual phenotype. Nouv Rev Fr Hematol. 1991;33(3):237-43.
  • Scott-Algara D, Vuillier F, Marasescu M, de Saint Martin J, Dighiero G. Serum levels of IL-2, IL-1α, TNF- α, and soluble receptor of IL-2 in HIV-1-infected patients. AIDS Res Hum Retroviruses. 1991 Apr;7(4):381-6. https://doi.org/10.1089/aid.1991.7.381
  • Dighiero G, Hart S, Lim A, Borche L, Levy R, Miller RA. Autoantibody activity of immunoglobulins isolated from B-cell follicular lymphomas. Blood. 1991 Aug 1;78(3):581-5. https://doi.org/10.1182/blood.V78.3.581.bloodjournal783581
  • Vuillier F, Scott-Algara D, Tortevoye P, Pialoux G, Dighiero G. Serial study of CD5+ and CD5- B cell subpopulations in 335 HIV seropositive patients. Clin Exp Immunol. 1991 Sep;85(3):476-80. https://doi.org/10.1111/j.1365-2249.1991.tb05752.x
  • Dighiero G, Travade P, Chevret S, Fenaux P, Chastang C, Binet JL. B-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL. Blood. 1991 Oct 15;78(8):1901-14. https://doi.org/10.1182/blood.V78.8.1901.bloodjournal7881901

1992

  • Cayota A, Vuillier F, Scott-Algara D, Feuillie V, Dighiero G. Impaired proliferative capacity and abnormal cytokine profile of naive and memory CD4 T cells from HIV-seropositive patients. Clin Exp Immunol. 1992 Jun;88(3):478-83. https://doi.org/10.1111/j.1365-2249.1992.tb06475.x
  • Vuillier F, Claisse JF, Vandenvelde C, Travade P, Magnac C, Chevret S, Desablens B, Binet JL, Dighiero G. Evaluation of residual disease in B-cell chronic lymphocytic leukemia patients in clinical and bone-marrow remission using CD5-CD19 markers and PCR study of gene rearrangements. Leuk Lymphoma. 1992 Jun;7(3):195-204. https://doi.org/10.3109/10428199209053623
  • Montserrat E, Binet JL, Catovsky D, Dighiero G, Gale RP, Rai KR, Rozman C. 5th International Workshop on Chronic Lymphocytic Leukemia. Leuk Res. 1992 Jun-Jul;16(6-7):717-20. https://doi.org/10.1016/0145-2126(92)90023-Z
  • Dighiero G. Autoantibody activity and V gene usage by B-cell malignancies. Leuk Lymphoma. 1992 Nov;8(4-5):345-51. https://doi.org/10.3109/10428199209051013
  • Scott-Algara D, Vuillier F, Cayota A, Dighiero G. Natural killer (NK) cell activity during HIV infection: a decrease in NK activity is observed at the clonal level and is not restored after in vitro long-term culture of NK cells. Clin Exp Immunol. 1992 Nov;90(2):181-7. https://doi.org/10.1111/j.1365-2249.1992.tb07925.x

1993

  • Dighiero G. Hypogammaglobulinemia and disordered immunity in CLL. In Cheson B, ed. Chronic Lymphocytic Leukemia: Scientific Advances and Clinical Developments. New York, NY: Marcel Dekker; 1993:167-180.
  • Dighiero G. B cell malignancies frequently reflect expansion of the autoreactive B cell repertoire, although the mechanism accounting for this remains controversial. Blood Cells. 1993;19(3):626-30; discussion 631-2.
  • Houdayer M, Bouvet JP, Wolff A, Magnac C, Guillemot JC, Borche L, Dighiero G. Simultaneous presence, in one serum, of four monoclonal antibodies that might correspond to different steps in a clonal evolution from polyreactive to monoreactive antibodies. J Immunol. 1993 Jan 1;150(1):311-9. https://www.jimmunol.org/content/150/1/311.long
  • Cayota A, Vuillier F, Scott-Algara D, Feuillie V, Dighiero G. Differential requirements for HIV-1 replication in naive and memory CD4 T cells from asymptomatic HIV-1 seropositive carriers and AIDS patients. Clin Exp Immunol. 1993 Feb;91(2):241-8. https://doi.org/10.1111/j.1365-2249.1993.tb05890.x
  • Scott-Algara D, Vuillier F, Cayota A, Rame V, Guetard D, Moncany ML, Marasescu M, Dauguet C, Dighiero G. In vitro non-productive infection of purified natural killer cells by the BRU isolate of the human immunodeficiency virus type 1. J Gen Virol. 1993 Apr;74 (Pt 4):725-31. https://doi.org/10.1099/0022-1317-74-4-725
  • Pritsch O, Magnac C, Dumas G, Egile C, Dighiero G. V gene usage by seven hybrids derived from CD5+ B-cell chronic lymphocytic leukemia and displaying autoantibody activity. Blood. 1993 Nov 15;82(10):3103-12. https://doi.org/10.1182/blood.V82.10.3103.bloodjournal82103103
  • Dighiero G. Biology of the neoplastic lymphocyte in B-CLL. Baillieres Clin Haematol. 1993 Dec;6(4):807-20.

1994

  • Dighiero G. Potential immunological action of purine nucleoside analogues. Drugs. 1994;47 Suppl 6:57-62. https://doi.org/10.2165/00003495-199400476-00009
  • De la Fuente MA, Egile C, Pereira A, Juan M, Vivanco F, Roelcke D, Dighiero G, Gallart T. Characterization of a monoclonal IgMK (IgMGAS) anti-Gd cold agglutinin (CA). Its coexistence with a monoclonal IgG3K (IgGGAS) without CA activity that might be clonally related to IgMGAS. Blood. 1994 Mar 1;83(5):1310-22. https://doi.org/10.1182/blood.V83.5.1310.1310
  • Cayota A, Vuillier F, Siciliano J, Dighiero G. Defective protein tyrosine phosphorylation and altered levels of p59fyn and p56lck in CD4 T cells from HIV-1 infected patients. Int Immunol. 1994 Apr;6(4):611-21. https://doi.org/10.1093/intimm/6.4.611
  • Montserrat E, Binet JL, Dighiero G, Gale RP, Juliusson G, Keating M, Rai KR. Chronic lymphoproliferative disorders. Rev Invest Clin. 1994 Apr;Suppl:52-8.
  • French Cooperative Group on Chronic Lymphocytic Leukemia. Is the CHOP regimen a good treatment for advanced CLL? Results from two randomized clinical trials. French Cooperative Group on Chronic Lymphocytic Leukemia. Leuk Lymphoma. 1994 May;13(5-6):449-56. https://doi.org/10.3109/10428199409049634
  • Schroeder HW Jr, Dighiero G. The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire. Immunol Today. 1994 Jun;15(6):288-94. https://doi.org/10.1016/0167-5699(94)90009-4
  • Gale RP, Caligaris-Cappio F, Dighiero G, Keating M, Montserrat E, Rai K. Recent progress in chronic lymphocytic leukemia. International Workshop on chronic Lymphocytic Leukemia. Leukemia. 1994 Sep;8(9):1610-4.
  • Scott-Algara D, Lafon M, Vuillier F, Pialoux G, Dauguet C, Dighiero G. Viral superantigen-induced hyporesponsiveness of T cells and polyclonal B cell activation in HIV-1 infection. Eur J Immunol. 1994 Nov;24(11):2595-601. https://doi.org/10.1002/eji.1830241105

1995

  • Pico JL, Bourhis JH, Bennaceur AL, Beaujean F, Bayle C, Ibrahim A, Girinski T, Hayat M, Dighiero G, Tchernia G. Engraftment of CD34+ peripheral blood progenitor cells into multiple myeloma patients following total body irradiation. Nouv Rev Fr Hematol. 1995;37(6):381-3.
  • Maloum K, Magnac C, Pritsch O, Binet JL, Merle-Béral H, Dighiero G. Skewed rearrangement of the VH4-21 gene during pre-B acute lymphoblastic leukemia. Leuk Lymphoma. 1995 May;17(5-6):435-41. https://doi.org/10.3109/10428199509056854
  • Vuillier F, Scott-Algara D, Cayota A, Siciliano J, Nugeyre MT, Dighiero G. Flow cytometric analysis of protein-tyrosine phosphorylation in peripheral T cell subsets. Application to healthy and HIV-seropositive subjects. J Immunol Methods. 1995 Sep 11;185(1):43-56. https://doi.org/10.1016/0022-1759(95)00103-H
  • Cardona A, Pritsch O, Dumas G, Bach JF, Dighiero G. Evidence for an antigen-driven selection process in human autoantibodies against acetylcholine receptor. Mol Immunol. 1995 Nov;32(16):1215-23. https://doi.org/10.1016/0161-5890(95)00101-8
  • Maloum K, Davi F, Magnac C, Pritsch O, McIntyre E, Valensi F, Binet JL, Merle-Béral H, Dighiero G. Analysis of VH gene expression in CD5+ and CD5- B-cell chronic lymphocytic leukemia. Blood. 1995 Nov 15;86(10):3883-90. https://doi.org/10.1182/blood.V86.10.3883.bloodjournal86103883

1996

  • Dighiero G. Autoimmunity and B-cell malignancies. Verh Dtsch Ges Pathol. 1996;80:148-59.
  • Eclache V, Magnac C, Pritsch O, Delecluse HJ, Davi F, Raphaël M, Dighiero G. Complete nucleotide sequence of Ig V genes in three cases of Burkitt lymphoma associated with AIDS. Leuk Lymphoma. 1996 Jan;20(3-4):281-90. https://doi.org/10.3109/10428199609051619
  • Cayota A, Vuillier F, Gonzalez G, Dighiero G. CD4+ lymphocytes from HIV-infected patients display impaired CD45-associated tyrosine phosphatase activity which is enhanced by anti-oxidants. Clin Exp Immunol. 1996 Apr;104(1):11-7. https://doi.org/10.1046/j.1365-2249.1996.d01-652.x
  • Diaw L, Lefebvre d’Hellencourt C, Cornillet I, Vuillier F, Guenounou M, Dighiero G. Expression and production of cytokines by heterohybrids and their parental B cells in CLL. Leuk Lymphoma. 1996 Apr;21(3-4):281-91. https://doi.org/10.3109/10428199209067609
  • Cayota A, Vuillier F, Gonzalez G, Dighiero G. In vitro antioxidant treatment recovers proliferative responses of anergic CD4+ lymphocytes from human immunodeficiency virus-infected individuals. Blood. 1996 Jun 1;87(11):4746-53. https://doi.org/10.1182/blood.V87.11.4746.bloodjournal87114746
  • Dighiero G, Kipps T, Schroeder HW, Chiorazzi N, Stevenson F, Silberstein LE, Caligaris-Cappio F, Ferrarini M. What is the CLL B-lymphocyte? Leuk Lymphoma. 1996 Oct;22 Suppl 2:13-39. https://doi.org/10.3109/10428199609102700
  • Davi F, Maloum K, Michel A, Pritsch O, Magnac C, Macintyre E, Salomon-Nguyen F, Binet JL, Dighiero G, Merle-Béral H. High frequency of somatic mutations in the VH genes expressed in prolymphocytic leukemia. Blood. 1996 Nov 15;88(10):3953-61. https://doi.org/10.1182/blood.V88.10.3953.bloodjournal88103953
  • Pritsch O, Hudry-Clergeon G, Buckle M, Petillot Y, Bouvet JP, Gagnon J, Dighiero G. Can immunoglobulin C(H)1 constant region domain modulate antigen binding affinity of antibodies? J Clin Invest. 1996 Nov 15;98(10):2235-43. https://doi.org/10.1172/JCI119033
  • Dighiero G, Binet JL. Chronic lymphocytic leukemia. Hematol Cell Ther. 1996 Dec;38 Suppl 2:S41-61.
  • Dighiero G. Adverse and beneficial immunological effects of purine nucleoside analogues. Hematol Cell Ther. 1996 Dec;38 Suppl 2:S75-81.

1997

1998

  • Bouvet JP, Dighiero G. From natural polyreactive autoantibodies to à la carte monoreactive antibodies to infectious agents: is it a small world after all? Infect Immun. 1998 Jan;66(1):1-4. https://iai.asm.org/content/66/1/1.long
  • Dighiero G. Autoimmunity and B-cell malignancies. Hematol Cell Ther. 1998 Feb;40(1):1-9.
  • Pritsch O, Maloum K, Dighiero G. Basic biology of autoimmune phenomena in chronic lymphocytic leukemia. Semin Oncol. 1998 Feb;25(1):34-41.
  • Maloum K, Magnac C, Azgui Z, Cau C, Charlotte F, Binet JL, Merle-Béral H, Dighiero G. VH gene expression in hairy cell leukaemia. Br J Haematol. 1998 Apr;101(1):171-8. https://doi.org/10.1046/j.1365-2141.1998.00653.x
  • Dighiero G, Maloum K, Desablens B, Cazin B, Navarro M, Leblay R, Leporrier M, Jaubert J, Lepeu G, Dreyfus B, Binet JL, Travade P. Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia. N Engl J Med. 1998 May 21;338(21):1506-14. https://doi.org/10.1056/NEJM199805213382104
  • Gonzalez H, Leblond V, Azar N, Sutton L, Gabarre J, Binet JL, Vernant JP, Dighiero G. Severe autoimmune hemolytic anemia in eight patients treated with fludarabine. Hematol Cell Ther. 1998 Jun;40(3):113-8.
  • Fais F, Ghiotto F, Hashimoto S, Sellars B, Valetto A, Allen SL, Schulman P, Vinciguerra VP, Rai K, Rassenti LZ, Kipps TJ, Dighiero G, Schroeder HW Jr, Ferrarini M, Chiorazzi N. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest. 1998 Oct 15;102(8):1515-25. https://doi.org/10.1172/JCI3009

1999

  • Pritsch O, Dighiero G. Autoimmunity and B-cell malignancies. In Paul S, Ed. Autoimmune Reactions. Totowa, NJ: Humana Press; 1999: 19-30.
  • Dighiero G. Les postulats apparemment opposés d’Ehrlich (Horror autotoxicus) et de Metchnikoff (autoimmunisation physiologique) ne sont pas inconciliables. Bull Acad Natl Med. 1999;183(6):1153-63; discussion 1163-4.
  • Magnac C, Sutton L, Cazin B, Laurent C, Binet JL, Merle-Béral H, Dighiero G, Maloum K. Detection of minimal residual disease in B chronic lymphocytic leukemia (CLL). Hematol Cell Ther. 1999 Feb;41(1):13-8. https://doi.org/10.1007/s00282-999-0013-y
  • Brito C, Naviliat M, Tiscornia AC, Vuillier F, Gualco G, Dighiero G, Radi R, Cayota AM. Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death. J Immunol. 1999 Mar 15;162(6):3356-66. https://www.jimmunol.org/content/162/6/3356.long
  • CLL Trialists’ Collaborative Group. Chemotherapeutic options in chronic lymphocytic leukemia: a meta-analysis of the randomized trials. CLL Trialists’ Collaborative Group. J Natl Cancer Inst. 1999 May 19;91(10):861-8. https://doi.org/10.1093/jnci/91.10.861
  • Havouis S, Dumas G, Avé P, Pritsch O, Huerre M, Dighiero G, Pourcel C. A murine transgenic model of human cold agglutinin disease. Haematologica. 1999 Jun;84 Suppl EHA-4:67-9.
  • Dighiero G, Rose NR. Critical self-epitopes are key to the understanding of self-tolerance and autoimmunity. Immunol Today. 1999 Sep;20(9):423-8. https://doi.org/10.1016/s0167-5699(99)01509-1
  • Diaw L, Siwarski D, Coleman A, Kim J, Jones GM, Dighiero G, Huppi K. Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomas. J Exp Med. 1999 Nov 15;190(10):1405-16. http://jem.rupress.org/content/190/10/1405.long
  • Payelle-Brogard B, Magnac C, Mauro FR, Mandelli F, Dighiero G. Analysis of the B-cell receptor B29 (CD79b) gene in familial chronic lymphocytic leukemia. Blood. 1999 Nov 15;94(10):3516-22. https://doi.org/10.1182/blood.V94.10.3516.422k09_3516_3522
  • Pritsch O, Troussard X, Magnac C, Mauro FR, Davi F, Payelle-Brogard B, Dumas G, Pulik M, Clerget F, Mandelli F, Chiorazzi N, Schroeder HW Jr, Leporrier M, Dighiero G. VH gene usage by family members affected with chronic lymphocytic leukaemia. Br J Haematol. 1999 Dec;107(3):616-24. https://doi.org/10.1046/j.1365-2141.1999.01757.x

2000

2001

  • Dighiero G. Randomized trials: what do they teach us about chronic lymphocytic leukemia treatment? In Cheson B, ed. Chronic Lymphocytic Leukemia. 2nd ed. New York, NY: Marcel Dekker; 2001: 161-174.
  • Lévy M, Edelman L, Dighiero G. Molecular characterization of a monoclonal murine anti-blood group A antibody. Immunol Lett. 2001 Feb 1;76(1):15-23. https://doi.org/10.1016/S0165-2478(00)00312-6
  • Bouvet JP, Quan CP, Dighiero G. Polyreactivity is not an artefact. J Immunol Methods. 2001 Aug 1;254(1-2):199-201. https://doi.org/10.1016/S0022-1759(01)00362-3
  • Leporrier M, Chevret S, Cazin B, Boudjerra N, Feugier P, Desablens B, Rapp MJ, Jaubert J, Autrand C, Divine M, Dreyfus B, Maloum K, Travade P, Dighiero G, Binet JL, Chastang C. Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients. Blood. 2001 Oct 15;98(8):2319-25. https://doi.org/10.1182/blood.V98.8.2319
  • Vuillier F, Maloum K, Thomas EK, Jouanne C, Dighiero G, Scott-Algara D. Functional monocyte-derived dendritic cells can be generated in chronic lymphocytic leukaemia. Br J Haematol. 2001 Dec;115(4):831-44. https://doi.org/10.1046/j.1365-2141.2001.03223.x

2002

  • Dighiero G. La Leucémie Lymphoïde Chronique: une maladie unique ou deux maladies distinctes? Bull Acad Natl Med. 2002;186(7):1251-66; discussion 1266-8.
  • Havouis S, Dumas G, Chambaud I, Ave P, Huerre M, Blanchard A, Dighiero G, Pourcel C. Transgenic B lymphocytes expressing a human cold agglutinin escape tolerance following experimental infection of mice by Mycoplasma pulmonis. Eur J Immunol. 2002 Apr;32(4):1147-56. https://doi.org/10.1002/1521-4141(200204)32:4%3C1147::AID-IMMU1147%3E3.0.CO;2-O
  • Payelle-Brogard B, Magnac C, Alcover A, Roux P, Dighiero G. Defective assembly of the B-cell receptor chains accounts for its low expression in B-chronic lymphocytic leukaemia. Br J Haematol. 2002 Sep;118(4):976-85. https://doi.org/10.1046/j.1365-2141.2002.03759.x
  • Dighiero G. Is chronic lymphocytic leukemia one disease? Haematologica. 2002 Dec;87(12):1233-5. http://www.haematologica.org/content/87/12/1233.long
  • Oppezzo P, Magnac C, Bianchi S, Vuillier F, Tiscornia A, Dumas G, Payelle-Brogard B, Ajchenbaum-Cymbalista F, Dighiero G, Pritsch O. Do CLL B cells correspond to naive or memory B-lymphocytes? Evidence for an active Ig switch unrelated to phenotype expression and Ig mutational pattern in B-CLL cells. Leukemia. 2002 Dec;16(12):2438-46. https://doi.org/10.1038/sj.leu.2402731
  • Theodorou I, Abel L, Mauro F, Duprey B, Magnac C, Payelle-Brogard B, Davi F, Dighiero G. High occurence of DRB1 11 in chronic lymphocytic leukaemia families. Br J Haematol. 2002 Dec;119(3):713-5. https://doi.org/10.1046/j.1365-2141.2002.03926.x

2003

  • Magnac C, Porcher R, Davi F, Nataf J, Payelle-Brogard B, Tang RP, Oppezzo P, Lévy V, Dighiero G, Ajchenbaum-Cymbalista F. Predictive value of serum thymidine kinase level for Ig-V mutational status in B-CLL. Leukemia. 2003 Jan;17(1):133-7. https://doi.org/10.1038/sj.leu.2402780
  • Vuillier F, Maloum K, Thomas EK, Magnac C, Dumas G, Payelle-Brogard B, Oppezzo P, Dighiero G, Scott-Algara D. Idiotype-pulsed dendritic cells are able to induce antitumoral cytotoxic CD8 cells in chronic lymphocytic leukaemia. Br J Haematol. 2003 Jan;120(2):243-50. https://doi.org/10.1046/j.1365-2141.2003.04075.x
  • Oppezzo P, Vuillier F, Vasconcelos Y, Dumas G, Magnac C, Payelle-Brogard B, Pritsch O, Dighiero G. Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation. Blood. 2003 May 15;101(10):4029-32. Epub 2003 Jan 9. https://doi.org/10.1182/blood-2002-10-3175
  • Payelle-Brogard B, Magnac C, Oppezzo P, Dumas G, Dighiero G, Vuillier F. Retention and defective assembly of the B-cell receptor in the endoplasmic reticulum of chronic lymphocytic leukaemia B cells cannot be reverted upon CD40 ligand stimulation. Leukemia. 2003 Jun;17(6):1196-9. https://doi.org/10.1038/sj.leu.2402944
  • Oppezzo P, Dighiero G. Autoanticorps, tolérance et auto-immunité. Pathol Biol (Paris). 2003 Jul;51(5):297-304. https://doi.org/10.1016/S0369-8114(02)00318-8
  • Vuillier F, Dighiero G. Monocyte-derived dendritic cells in chronic lymphocytic leukemia. Leuk Lymphoma. 2003 Aug;44(8):1267-73. https://doi.org/10.1080/1042819031000079087
  • Vuillier F, Dighiero G. La thérapie cellulaire par des cellules dendritiques dans la leucémie lymphoïde chronique: état de la question. Bull Cancer. 2003 Aug-Sep;90(8-9):744-50.
  • Vasconcelos Y, Davi F, Levy V, Oppezzo P, Magnac C, Michel A, Yamamoto M, Pritsch O, Merle-Béral H, Maloum K, Ajchenbaum-Cymbalista F, Dighiero G. Binet’s staging system and VH genes are independent but complementary prognostic indicators in chronic lymphocytic leukemia. J Clin Oncol. 2003 Nov 1;21(21):3928-32. https://doi.org/10.1200/JCO.2003.02.134
  • Dighiero G. Unsolved issues in CLL biology and management. Leukemia. 2003 Dec;17(12):2385-91. https://doi.org/10.1038/sj.leu.2403154

2004

  • Dighiero G. Guidelines for clinical management of CLL. In Faguet GB, ed. Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis, and Management. Totowa, NJ: Humana Press Inc. 2004; 219-240. https://www.springer.com/gp/book/9781588290991
  • Tiscornia AC, Cayota A, Landoni AI, Brito C, Oppezzo P, Vuillier F, Robello C, Dighiero G, Gabús R, Pritsch O. Post-transcriptional regulation of inducible nitric oxide synthase in chronic lymphocytic leukemia B cells in pro- and antiapoptotic culture conditions. Leukemia. 2004 Jan;18(1):48-56. https://doi.org/10.1038/sj.leu.2403169
  • Oppezzo P, Dumas G, Bouvet JP, Robello C, Cayota A, Pizarro JC, Dighiero G, Pritsch O. Somatic mutations can lead to a loss of superantigenic and polyreactive binding. Eur J Immunol. 2004 May;34(5):1423-32. https://doi.org/10.1002/eji.200424936
  • Dighiero G. Perspectives in chronic lymphocytic leukemia biology and management. Hematol Oncol Clin North Am. 2004 Aug;18(4):927-43. https://doi.org/10.1016/j.hoc.2004.04.002
  • Tchirkov A, Chaleteix C, Magnac C, Vasconcelos Y, Davi F, Michel A, Kwiatkowski F, Tournilhac O, Dighiero G, Travade P. hTERT expression and prognosis in B-chronic lymphocytic leukemia. Ann Oncol. 2004 Oct;15(10):1476-80. https://doi.org/10.1093/annonc/mdh389

2005

  • Dighiero G. CLL biology and prognosis. Hematology Am Soc Hematol Educ Program. 2005:278-84. https://doi.org/10.1182/asheducation-2005.1.278
  • Oppezzo P, Dighiero G. What do somatic hypermutation and class switch recombination teach us about chronic lymphocytic leukaemia pathogenesis? Curr Top Microbiol Immunol. 2005;294:71-89. https://doi.org/10.1007/3-540-29933-5_5
  • Ghia P, Stamatopoulos K, Belessi C, Moreno C, Stella S, Guida G, Michel A, Crespo M, Laoutaris N, Montserrat E, Anagnostopoulos A, Dighiero G, Fassas A, Caligaris-Cappio F, Davi F. Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Blood. 2005 Feb 15;105(4):1678-85. Epub 2004 Oct 5. https://doi.org/10.1182/blood-2004-07-2606
  • Oppezzo P, Dumas G, Lalanne AI, Payelle-Brogard B, Magnac C, Pritsch O, Dighiero G, Vuillier F. Different isoforms of BSAP regulate expression of AID in normal and chronic lymphocytic leukemia B cells. Blood. 2005 Mar 15;105(6):2495-503. Epub 2004 Nov 23. https://doi.org/10.1182/blood-2004-09-3644
  • Calin GA, Trapasso F, Shimizu M, Dumitru CD, Yendamuri S, Godwin AK, Ferracin M, Bernardi G, Chatterjee D, Baldassarre G, Rattan S, Alder H, Mabuchi H, Shiraishi T, Hansen LL, Overgaard J, Herlea V, Mauro FR, Dighiero G, Movsas B, Rassenti L, Kipps T, Baffa R, Fusco A, Mori M, Russo G, Liu CG, Neuberg D, Bullrich F, Negrini M, Croce CM. Familial cancer associated with a polymorphism in ARLTS1. N Engl J Med. 2005 Apr 21;352(16):1667-76. https://doi.org/10.1056/NEJMoa042280
  • Vuillier F, Dumas G, Magnac C, Prevost MC, Lalanne AI, Oppezzo P, Melanitou E, Dighiero G, Payelle-Brogard B. Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the mu and CD79a chains. Blood. 2005 Apr 1;105(7):2933-40. Epub 2004 Dec 9. https://doi.org/10.1182/blood-2004-09-3643
  • Oppezzo P, Vasconcelos Y, Settegrana C, Jeannel D, Vuillier F, Legarff-Tavernier M, Kimura EY, Bechet S, Dumas G, Brissard M, Merle-Béral H, Yamamoto M, Dighiero G, Davi F. The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia. Blood. 2005 Jul 15;106(2):650-7. Epub 2005 Mar 31. https://doi.org/10.1182/blood-2004-08-3344
  • Vasconcelos Y, De Vos J, Vallat L, Rème T, Lalanne AI, Wanherdrick K, Michel A, Nguyen-Khac F, Oppezzo P, Magnac C, Maloum K, Ajchenbaum-Cymbalista F, Troussard X, Leporrier M, Klein B, Dighiero G, Davi F. Gene expression profiling of chronic lymphocytic leukemia can discriminate cases with stable disease and mutated Ig genes from those with progressive disease and unmutated Ig genes. Leukemia. 2005 Nov;19(11):2002-5. https://doi.org/10.1038/sj.leu.2403865

2006

  • Binet JL, Caligaris-Cappio F, Catovsky D, Cheson B, Davis T, Dighiero G, Döhner H, Hallek M, Hillmen P, Keating M, Montserrat E, Kipps TJ, Rai K. Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia. Blood. 2006 Feb 1;107(3):859-61. Epub 2005 Oct 13. https://doi.org/10.1182/blood-2005-04-1677
  • Payelle-Brogard B, Dumas G, Magnac C, Lalanne AI, Dighiero G, Vuillier F. Abnormal levels of the α chain of the CD22 adhesion molecule may account for low CD22 surface expression in chronic lymphocytic leukemia. Leukemia. 2006 May;20(5):877-8. https://doi.org/10.1038/sj.leu.2404155

2007

  • Auer RL, Dighiero G, Goldin LR, Syndercombe-Court D, Jones C, McElwaine S, Newland AC, Fegan CD, Caporaso N, Cotter FE. Trinucleotide repeat dynamic mutation identifying susceptibility in familial and sporadic chronic lymphocytic leukaemia. Br J Haematol. 2007 Jan;136(1):73-9. Epub 2006 Nov 20. https://doi.org/10.1111/j.1365-2141.2006.06388.x
  • Stamatopoulos K, Belessi C, Moreno C, Boudjograh M, Guida G, Smilevska T, Belhoul L, Stella S, Stavroyianni N, Crespo M, Hadzidimitriou A, Sutton L, Bosch F, Laoutaris N, Anagnostopoulos A, Montserrat E, Fassas A, Dighiero G, Caligaris-Cappio F, Merle-Béral H, Ghia P, Davi F. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations. Blood. 2007 Jan 1;109(1):259-70. Epub 2006 Sep 19. https://doi.org/10.1182/blood-2006-03-012948

2008

  • Marton S, Garcia MR, Robello C, Persson H, Trajtenberg F, Pritsch O, Rovira C, Naya H, Dighiero G, Cayota A. Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis. Leukemia. 2008 Feb;22(2):330-8. Epub 2007 Nov 8. https://doi.org/10.1038/sj.leu.2405022
  • Dighiero G, Hamblin TJ. Chronic lymphocytic leukaemia. Lancet. 2008 Mar 22;371(9617):1017-29. https://doi.org/10.1016/S0140-6736(08)60456-0
  • Cairoli E, Scott-Algara D, Pritsch O, Dighiero G, Cayota A. HIV-1 induced decrease of nitric oxide production and inducible nitric oxide synthase expression during in vivo and in vitro infection. Clin Immunol. 2008 Apr;127(1):26-33. Epub 2008 Jan 3. https://doi.org/10.1016/j.clim.2007.11.015
  • Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating MJ, Montserrat E, Rai KR, Kipps TJ. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008 Jun 15;111(12):5446-56. Epub 2008 Jan 23. https://doi.org/10.1182/blood-2007-06-093906
  • Véronèse L, Tournilhac O, Verrelle P, Davi F, Dighiero G, Chautard E, Veyrat-Masson R, Kwiatkowski F, Goumy C, Vago P, Travade P, Tchirkov A. Low MCL-1 mRNA expression correlates with prolonged survival in B-cell chronic lymphocytic leukemia. Leukemia. 2008 Jun;22(6):1291-3. Epub 2007 Nov 29. https://doi.org/10.1038/sj.leu.2405052
  • Dighiero G. Monoclonal B-cell lymphocytosis–a frequent premalignant condition. N Engl J Med. 2008 Aug 7;359(6):638-40. https://doi.org/10.1056/NEJMe0804663

2009

  • Véronèse L, Tournilhac O, Verrelle P, Davi F, Dighiero G, Chautard E, Veyrat-Masson R, Kwiatkowski F, Goumy C, Gouas L, Bay JO, Vago P, Tchirkov A. Strong correlation between VEGF and MCL-1 mRNA expression levels in B-cell chronic lymphocytic leukemia. Leuk Res. 2009 Dec;33(12):1623-6. Epub 2009 May 31. https://doi.org/10.1016/j.leukres.2009.05.003

2010

  • Palacios F, Moreno P, Morande P, Abreu C, Correa A, Porro V, Landoni AI, Gabus R, Giordano M, Dighiero G, Pritsch O, Oppezzo P. High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease. Blood. 2010 Jun 3;115(22):4488-96. Epub 2010 Mar 16. https://doi.org/10.1182/blood-2009-12-257758
  • Bianchi S, Moreno P, Landoni AI, Naya H, Oppezzo P, Dighiero G, Gabús R, Pritsch O. Immunoglobulin heavy chain V-D-J gene rearrangement and mutational status in Uruguayan patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2010 Nov;51(11):2070-8. Epub 2010 Oct 7. https://doi.org/10.3109/10428194.2010.522283

2012

  • Rego N, Bianchi S, Moreno P, Persson H, Kvist A, Pena A, Oppezzo P, Naya H, Rovira C, Dighiero G, Pritsch O. Search for an aetiological virus candidate in chronic lymphocytic leukaemia by extensive transcriptome analysis. Br J Haematol. 2012 Jun;157(6):709-17. Epub 2012 Apr 10. https://doi.org/10.1111/j.1365-2141.2012.09116.x

2013

  • Correa A, Trajtenberg F, Obal G, Pritsch O, Dighiero G, Oppezzo P, Buschiazzo A. Structure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulation. Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):388-97. Epub 2013 Feb 16. https://doi.org/10.1107/S0907444912048664
  • Moreno P, Abreu C, Borge M, Palacios F, Morande P, Pegazzano M, Bianchi S, Landoni AI, Agrelo R, Giordano M, Dighiero G, Gamberale R, Oppezzo P. Lipoprotein lipase expression in unmutated CLL patients is the consequence of a demethylation process induced by the microenvironment. Leukemia. 2013 Mar;27(3):721-5. Epub 2012 Jul 25. https://doi.org/10.1038/leu.2012.212
  • Abreu C, Moreno P, Palacios F, Borge M, Morande P, Landoni AI, Gabus R, Dighiero G, Giordano M, Gamberale R, Oppezzo P. Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia. Leuk Lymphoma. 2013 Aug;54(8):1844-8. Epub 2013 Jun 21. https://doi.org/10.3109/10428194.2013.796057
  • Oppezzo P, Dighiero G. “Role of the B-cell receptor and the microenvironment in chronic lymphocytic leukemia”. Blood Cancer J. 2013 Sep 20;3:e149. https://doi.org/10.1038/bcj.2013.45

2014

  • Fischer S, Echeverría N, Moratorio G, Landoni AI, Dighiero G, Cristina J, Oppezzo P, Moreno P. Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients. Leuk Res Rep. 2014 Jul 25;3(2):70-2. eCollection 2014. https://doi.org/10.1016/j.lrr.2014.06.005

2015

  • Palacios F, Abreu C, Prieto D, Morande P, Ruiz S, Fernández-Calero T, Naya H, Libisch G, Robello C, Landoni AI, Gabus R, Dighiero G, Oppezzo P. Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation. Leukemia. 2015 Jan;29(1):115-25. Epub 2014 May 14. https://doi.org/10.1038/leu.2014.158
  • Morande PE, Borge M, Abreu C, Galletti J, Zanetti SR, Nannini P, Bezares RF, Pantano S, Dighiero G, Oppezzo P, Gamberale R, Giordano M. Surface localization of high-mobility group nucleosome-binding protein 2 on leukemic B cells from patients with chronic lymphocytic leukemia is related to secondary autoimmune hemolytic anemia. Leuk Lymphoma. 2015 Apr;56(4):1115-22. Epub 2015 Jan 21. https://doi.org/10.3109/10428194.2014.957205

2017

  • Prieto D, Sotelo N, Seija N, Sernbo S, Abreu C, Durán R, Gil M, Sicco E, Irigoin V, Oliver C, Landoni AI, Gabus R, Dighiero G, Oppezzo P. S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-κB activity during disease progression. Blood. 2017 Aug 10;130(6):777-788. Epub 2017 Jun 8. https://doi.org/10.1182/blood-2017-02-769851

2018

  • Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O’Brien S, Robak T, Seymour JF, Kipps TJ. iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood. 2018 Jun 21;131(25):2745-2760. Epub 2018 Mar 14. https://doi.org/10.1182/blood-2017-09-806398
  • Prieto D, Seija N, Uriepero A, Souto-Padron T, Oliver C, Irigoin V, Guillermo C, Navarrete MA, Inés Landoni A, Dighiero G, Gabus R, Giordano M, Oppezzo P. LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL. Br J Haematol. 2018 Aug;182(4):521-525. Epub 2018 Jun 28. https://doi.org/10.1111/bjh.15427

2019

  • Stanganelli C, Torres DC, Ortega C, Sotelo N, Márquez ME, Segges P, Muniz MTC, Bigni RS, Campregher PV, Sabino A, Gomes CP, de Chauffaille MLLF, Arrais Rodrigues C, Yamamoto M, Abdelhay E, Cabrera J, Deglesne PA, López JL, Galvano C, Krzywinski A, Bezares R, Lang C, Zanella L, Agriello E, Cabrejo M, Gabús R, Dighiero G, Oppezzo P, Hassan R, Slavutsky I. Distinctive IGHV gene usage and stereotyped receptors in South American patients with chronic lymphocytic leukemia. Hematol Oncol. 2019 Dec;37(5):644-648. Epub 2019 Oct 31. https://doi.org/10.1002/hon.2661

2020

  • de Faria-Moss M, Yamamoto M, Arrais-Rodrigues C, Criado I, Perez-Gomez C, Chauffaille ML, Gonçalves MV, Kimura E, Koulieris E, Borges F, Dighiero G, Bosco-Pesquero J, Almeida J, Orfao A. High frequency of chronic lymphocytic leukemia-like low-count monoclonal B-cell lymphocytosis in Japanese descendants living in Brazil. Haematologica. 2020 Jun;105(6):e298-e301. Epub 2019 Nov 14. https://doi.org/10.3324/haematol.2019.230813

Page last updated on June 5, 2020.

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