Collected Works of Freda K. Stevenson

Introduction

Photo of Freda Stevenson

Dr. Freda Stevenson’s life-long work has focused on the B cell biology of human lymphoproliferative disease. She began her work investigating the cell surface antigens of B lymphocytes and learned that anti-idiotype antibodies directed against the B cell receptor could lead to B cell death in leukemic and lymphomatous cells. She is credited with the discovery of two clinically significant subsets in CLL based on IGHV mutational status. Her laboratory was been involved in the design and testing of gene-based vaccines directed against tumor antigens, as well as the testing of the anti-CD38 monoclonal antibody that led to the development of daratumumab for the treatment of patients with multiple myeloma.

Dr. Stevenson received her PhD in Biochemistry at the University of Oxford in 1964. She is a Professor of Immunology at the University of Southampton and a consultant at the Southampton University Hospitals. She was awarded the European Hematology Association’s Jean Bernard Lifetime Achievement Award in 2014 and the Rai Binet Medal from iwCLL in 2015; in both of these awards, she was the first woman, first non-clinical scientist and first UK citizen to be so recognized. She was also awarded the American Society of Hematology Henry M. Stratton Medal in 2018 for seminal contributions in her research.

Collected Works

1967

  • Stevenson FK, Stevenson GT. Antibody activity in the presence of urea or guanidine. Biochim Biophys Acta. 1967 Jan 18;133(1):162-4. https://doi.org/10.1016/0005-2795(67)90049-9
  • Stevenson FK, Kent PW, Fisher D. Quantitative determination of xylose in mucopolysaccharide derivatives. Chem Ind. 1967 Apr 29;17:703-4.

1968

1969

1970

1971

  • Stevenson FK, Cleave AJ, Kent PW. The effect of ions on the viscometric and ultracentrifugal behaviour of Tamm-Horsfall glycoprotein. Biochim Biophys Acta. 1971 Apr 27;236(1):59-66. https://doi.org/10.1016/0005-2795(71)90149-8

1972

1973

1975

1976

  • Hough DW, Eady RP, Hamblin TJ, Stevenson FK, Stevenson GT. Anti-idiotype sera raised against surface immunoglobulin of human neoplastic lymphocytes. J Exp Med. 1976 Oct 1;144(4):960-9. https://doi.org/10.1084/jem.144.4.960

1977

  • Stevenson FK, Elliott EV, Stevenson GT. Some effects on leukaemic B lymphocytes of antibodies to defined regions of their surface immunoglobulin. Immunology. 1977 Apr;32(4):549-57. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1445483/
  • Stevenson GT, Elliott EV, Stevenson FK. Idiotypic determinants on the surface immunoglobulin of neoplastic lymphocytes: a therapeutic target. Fed Proc. 1977 Aug;36(9):2268-71.

1978

1979

  • Glennie M, Stevenson FK, Stevenson GT, Virji M. Cross-linking of lymphocytic surface immunoglobulin inhibits its production via a cyclic nucleotide mechanism. Nature. 1979 Sep 27;281(5729):305-7. https://doi.org/10.1038/281305a0

1980

  • Hamblin TJ, Abdul-Ahad AK, Gordon J, Stevenson FK, Stevenson GT. Preliminary experience in treating lymphocytic leukaemia with antibody to immunoglobulin idiotypes on the cell surfaces. Br J Cancer. 1980 Oct;42(4):495-502. https://doi.org/10.1038/bjc.1980.271
  • Stevenson FK, Morris D, Stevenson GT. Immunoglobulin produced by guinea-pig leukaemic B lymphocytes: its source and use as a monitor of tumour load. Immunology. 1980 Oct;41(2):313-21. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458168/
  • Stevenson FK, Hamblin TJ, Stevenson GT, Tutt AL. Extracellular idiotypic immunoglobulin arising from human leukemic B lymphocytes. J Exp Med. 1980 Dec 1;152(6):1484-96. https://doi.org/10.1084/jem.152.6.1484

1981

  • Gordon J, Hamblin TJ, Smith JL, Stevenson FK, Stevenson GT. A human b-cell lymphoma synthesizing and expressing surface μ-chain in the absence of detectable light chain. Blood. 1981 Sep;58(3):552-6. https://doi.org/10.1182/blood.V58.3.552.552
  • Stevenson FK, Hamblin TJ, Stevenson GT. The nature of the immunoglobulin G on the surface of B lymphocytes in chronic lymphocytic leukemia. J Exp Med. 1981 Dec 1;154(6):1965-9. https://doi.org/10.1084/jem.154.6.1965

1982

  • Mufti GJ, Hamblin TJ, Stevenson FK, Fitchett M. Polycythaemia rubra vera and hairy cell leukaemia in the same patient: studies on the spleen. J Clin Pathol. 1982 Dec;35(12):1312-5. https://doi.org/10.1136/jcp.35.12.1312

1983

  • Stevenson GT, Stevenson FK. Treatment of lymphoid tumors with anti-idiotype antibodies. Springer Semin Immunopathol. 1983;6(1):99-115. https://doi.org/10.1007/bf01857369
  • Stevenson FK, Stevenson GT, Tutt AL. The export of immunoglobulin D by human neoplastic B lymphocytes. J Exp Med. 1983 Jan 1;157(1):337-41. https://doi.org/10.1084/jem.157.1.337
  • Stevenson FK, Gordon J. Immunization with idiotypic immunoglobulin protects against development of B lymphocytic leukemia, but emerging tumor cells can evade antibody attack by modulation. J Immunol. 1983 Feb;130(2):970-3. https://www.jimmunol.org/content/130/2/970.long
  • Stevenson FK, Spellerberg M, Smith JL. Monoclonal immunoglobulin light chain in urine of patients with B lymphocytic disease: its source and use as a diagnostic aid. Br J Cancer. 1983 May;47(5):607-12. https://doi.org/10.1038/bjc.1983.98
  • Tutt AL, Stevenson FK, Smith JL, Stevenson GT. Antibodies against urinary light chain idiotypes as agents for detection and destruction of human neoplastic B lymphocytes. J Immunol. 1983 Dec;131(6):3058-63. https://www.jimmunol.org/content/131/6/3058.long

1984

1985

  • Mufti GJ, Hamblin TJ, Stevenson FK, Fitchett M. Polycythemia rubra vera and hairy cell leukemia. Acta Haematol. 1985;73(3):189. https://doi.org/10.1159/000206322
  • Tutt AL, Stevenson FK, Slavin S, Stevenson GT. Secretion of idiotypic IgM by the mouse B-cell leukaemia (BCL1) occurs spontaneously in vitro and in vivo. Immunology. 1985 May;55(1):59-63. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1453581/
  • Stevenson GT, Glennie MJ, Paul FE, Stevenson FK, Watts HF, Wyeth P. Preparation and properties of FabIgG, a chimeric univalent antibody designed to attack tumour cells. Biosci Rep. 1985 Oct-Nov;5(10-11):991-8. https://doi.org/10.1007/bf01119911

1986

  • Walters MT, Stevenson FK, Herbert A, Cawley MI, Smith JL. Lymphoma in Sjögren’s syndrome: urinary monoclonal free light chains as a diagnostic aid and a means of tumour monitoring. Scand J Rheumatol. 1986;15(Suppl 61):114-7.
  • Stevenson FK, George AJ, Walters MT, Hamblin TJ. Analysis of soluble HLA class II antigenic material in patients with immunological diseases using monoclonal antibodies. J Immunol Methods. 1986 Feb 12;86(2):187-90. https://doi.org/10.1016/0022-1759(86)90451-5
  • Walters MT, Stevenson FK, Herbert A, Cawley MI, Smith JL. Urinary monoclonal free light chains in primary Sjögren’s syndrome: an aid to the diagnosis of malignant lymphoma. Ann Rheum Dis. 1986 Mar;45(3):210-9. https://doi.org/10.1136/ard.45.3.210
  • Stevenson FK, Stevenson GT. Therapeutic strategies for B cell malignancies involving idiotype-anti-idiotype interactions. Int Rev Immunol. 1986 Jul;1(3-4):303-33. https://doi.org/10.3109/08830188609056611
  • Stevenson FK, Wrightham M, Glennie MJ, Jones DB, Cattan AR, Feizi T, Hamblin TJ, Stevenson GT. Antibodies to shared idiotypes as agents for analysis and therapy for human B cell tumors. Blood. 1986 Aug;68(2):430-6. https://doi.org/10.1182/blood.V68.2.430.430
  • Stevenson FK. Idiotypes and diseases. Immunol Today. 1986 Oct;7(10):287-8. https://doi.org/10.1016/0167-5699(86)90059-9

1987

  • Stevenson FK, George AJ, Tutt AL, Glennie MJ, Stevenson GT. Involvement of innate and induced anti-idiotypic mechanisms in suppression of B cell tumors. Monogr Allergy. 1987;22:184-93.
  • George AJ, Tutt AL, Stevenson FK. Anti-idiotypic mechanisms involved in suppression of a mouse B cell lymphoma, BCL1. J Immunol. 1987 Jan 15;138(2):628-34. https://www.jimmunol.org/content/138/2/628.long
  • Hamblin TJ, Cattan AR, Glennie MJ, MacKenzie MR, Stevenson FK, Watts HF, Stevenson GT. Initial experience in treating human lymphoma with a chimeric univalent derivative of monoclonal anti-idiotype antibody. Blood. 1987 Mar;69(3):790-7. https://doi.org/10.1182/blood.V69.3.790.790
  • Wrightham M, Tutt AL, Glennie MJ, Hamblin TJ, Stevenson GT, Stevenson FK. Monoclonal anti-light chain idiotype as a tumor-specific probe for human neoplastic B lymphocytes. Blood. 1987 Mar;69(3):919-23. https://doi.org/10.1182/blood.V69.3.919.919
  • Gregg EO, Bridges SH, Youle RJ, Longo DL, Houston LL, Glennie MJ, Stevenson FK, Green I. Whole ricin and recombinant ricin A chain idiotype-specific immunotoxins for therapy of the guinea pig L2C B cell leukemia. J Immunol. 1987 Jun 15;138(12):4502-8. https://www.jimmunol.org/content/138/12/4502.long

1988

  • Gregg E, Hamblin T, Smith J, Stevenson F. Heterogeneity in neoplastic cell populations in chronic lymphocytic leukaemia defined by immunoglobulin expression and secretion in vitro. Leuk Res. 1988;12(2):123-7. https://doi.org/10.1016/0145-2126(88)90071-9
  • Stevenson FK, Smith GJ, North J, Glennie MG, Hamblin TJ. Use of a cross reacting anti-idiotype to identify normal counterparts of neoplastic cells. Nouv Rev Fr Hematol. 1988;30(5-6):299-300.
  • Stevenson GT, Glennie MJ, Hamblin TJ, Lane AC, Stevenson FK. Problems and prospects in the use of lymphoma idiotypes as therapeutic targets. Int J Cancer Suppl. 1988;3:9-12. https://doi.org/10.1002/ijc.2910410803
  • George AJ, Spellerberg MB, Stevenson FK. Idiotype vaccination leads to the emergence of a stable surface Ig-negative variant of the mouse lymphoma BCL1, with different growth characteristics. J Immunol. 1988 Mar 1;140(5):1695-701. https://www.jimmunol.org/content/140/5/1695.long
  • Smith JL, Oscier DG, Haegert DG, Jones DB, Howell M, Hodges E, Stevenson FK, Hamblin TJ. CD3+ CD8+ T cell lymphocytosis masking B cell leukaemia. J Clin Pathol. 1988 Jul;41(7):746-52. https://doi.org/10.1136/jcp.41.7.746
  • George AJ, Folkard SG, Hamblin TJ, Stevenson FK. Idiotypic vaccination as a treatment for a B cell lymphoma. J Immunol. 1988 Sep 15;141(6):2168-74. https://www.jimmunol.org/content/141/6/2168.long
  • Dearman RJ, Stevenson FK, Wrightham M, Hamblin TJ, Glennie MJ, Stevenson GT. Lymphokine-activated killer cells from normal and lymphoma subjects are cytotoxic for cells coated with antibody derivatives displaying human Fc gamma. Blood. 1988 Dec;72(6):1985-91. https://doi.org/10.1182/blood.V72.6.1985.1985

1989

  • George AJ, Stevenson FK. Prospects for the treatment of B cell tumors using idiotypic vaccination. Int Rev Immunol. 1989;4(4):271-310. https://doi.org/10.3109/08830188909044783
  • Stevenson FK, Smith GJ, North J, Hamblin TJ, Glennie MJ. Identification of normal B-cell counterparts of neoplastic cells which secrete cold agglutinins of anti-I and anti-i specificity. Br J Haematol. 1989 May;72(1):9-15. https://doi.org/10.1111/j.1365-2141.1989.tb07643.x
  • Hamblin TJ, Inzani V, Sadullah S, Stevenson FK, Williamson P, van der Plas J, Palmer P, Franks CR. A phase-II trial of recombinant interleukin-2 and 5-FU chemotherapy in patients with metastatic colorectal carcinoma. Cancer Treat Rev. 1989 Jun;16(Suppl A):163-7. https://doi.org/10.1016/0305-7372(89)90037-6
  • Walters MT, Stevenson FK, Goswami R, Smith JL, Cawley MI. Comparison of serum and synovial fluid concentrations of beta 2-microglobulin and C reactive protein in relation to clinical disease activity and synovial inflammation in rheumatoid arthritis. Ann Rheum Dis. 1989 Nov;48(11):905-11. https://doi.org/10.1136/ard.48.11.905

1990

  • Stevenson FK, George AJ, Glennie MJ. Anti-idiotypic therapy of leukemias and lymphomas. Chem Immunol. 1990;48:126-66.
  • Bell AJ, North J, Stevenson FK, Hamblin TJ. Peripheral blood stem cell autografts in myeloma. Bone Marrow Transplant. 1990 Jan;5(Suppl 1):52-4
  • Stevenson FK, Douglass WA, Spellerberg MB, Walters MT, Cawley MI. Soluble histocompatibility antigens in synovial fluids of patients with rheumatoid arthritis. Clin Exp Immunol. 1990 Apr;80(1):32-7. https://doi.org/10.1111/j.1365-2249.1990.tb06437.x
  • Jefferies LC, Stevenson FK, Goldman J, Bennett IM, Spitalnik SL, Silberstein LE. Anti-idiotypic antibodies specific for a pathologic anti-Pr2 cold agglutinin. Transfusion. 1990 Jul-Aug;30(6):495-502. https://doi.org/10.1046/j.1537-2995.1990.30690333478.x
  • George AJ, Stevenson FK. Humoral effector mechanisms in the immunity to cancer. Immunol Today. 1990 Oct;11(10):348-9. https://doi.org/10.1016/0167-5699(90)90138-y
  • Smith GJ, Spellerberg MB, North J, Hamblin TJ, Stevenson FK. Isolation and EBV-transformation of a minor population of normal human tonsillar B cells bearing a cold agglutinin-associated idiotope. J Autoimmun. 1990 Dec;3(6):759-71. https://doi.org/10.1016/s0896-8411(05)80042-3
  • Wilson A, George AJ, King CA, Stevenson FK. Recognition of a B cell lymphoma by anti-idiotypic T cells. J Immunol. 1990 Dec 1;145(11):3937-43. https://www.jimmunol.org/content/145/11/3937.long

1991

  • Dyke RJ, McBride H, George AJ, Hamblin TJ, Stevenson FK. Idiotypic vaccination against B-cell lymphoma leads to dormant tumour. Cell Immunol. 1991 Jan;132(1):70-83. https://doi.org/10.1016/0008-8749(91)90007-x
  • Stevenson FK, Bell AJ, Cusack R, Hamblin TJ, Slade CJ, Spellerberg MB, Stevenson GT. Preliminary studies for an immunotherapeutic approach to the treatment of human myeloma using chimeric anti-CD38 antibody. Blood. 1991 Mar 1;77(5):1071-9. https://doi.org/10.1182/blood.V77.5.1071.1071
  • George AJ, McBride HM, Glennie MJ, Smith LJ, Stevenson FK. Monoclonal antibodies raised against the idiotype of the murine B cell lymphoma, BCL1 act primarily with heavy chain determinants. Hybridoma. 1991 Apr;10(2):219-27. https://doi.org/10.1089/hyb.1991.10.219
  • Stevenson FK. Tumor vaccines. FASEB J. 1991 Jun;5(9):2250-7. https://doi.org/10.1096/fasebj.5.9.1860616
  • Pascual V, Victor K, Lelsz D, Spellerberg MB, Hamblin TJ, Thompson KM, Randen I, Natvig J, Capra JD, Stevenson FK. Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype. J Immunol. 1991 Jun 15;146(12):4385-91. https://www.jimmunol.org/content/146/12/4385.long
  • George AJ, Foreman RC, Stevenson FK. Characterisation of a light chain loss variant of the BCL1 lymphoma. Mol Immunol. 1991 Jul;28(7):789-99. https://doi.org/10.1016/0161-5890(91)90122-z
  • Mageed RA, MacKenzie LE, Stevenson FK, Yuksel B, Shokri F, Maziak BR, Jefferis R, Lydyard PM. Selective expression of a VHIV subfamily of immunoglobulin genes in human CD5+ B lymphocytes from cord blood. J Exp Med. 1991 Jul 1;174(1):109-13. https://doi.org/10.1084/jem.174.1.109
  • Thompson KM, Sutherland J, Barden G, Melamed MD, Randen I, Natvig JB, Pascual V, Capra JD, Stevenson FK. Human monoclonal antibodies against blood group antigens preferentially express a VH4-21 variable region gene-associated epitope. Scand J Immunol. 1991 Oct;34(4):509-18. https://doi.org/10.1111/j.1365-3083.1991.tb01574.x
  • Ling NR, Stevenson FK, Brown B. Urinary excretion of CD23 antigen in normal individuals and patients with chronic lymphocytic leukaemia (CLL). Clin Exp Immunol. 1991 Dec;86(3):360-6. https://doi.org/10.1111/j.1365-2249.1991.tb02938.x

1992

1993

  • King CA, Wills MR, Hamblin TJ, Stevenson FK. Idiotypic IgM on a B-cell surface requires processing for recognition by anti-idiotypic T cells. Cell Immunol. 1993 Apr 1;147(2):411-24. https://doi.org/10.1006/cimm.1993.1080
  • Stevenson FK, Spellerberg MB, Treasure J, Chapman CJ, Silberstein LE, Hamblin TJ, Jones DB. Differential usage of an Ig heavy chain variable region gene by human B-cell tumors. Blood. 1993 Jul 1;82(1):224-30. https://doi.org/10.1182/blood.V82.1.224.bloodjournal821224
  • Chapman CJ, Spellerberg MB, Smith GA, Carter SJ, Hamblin TJ, Stevenson FK. Autoanti-red cell antibodies synthesized by patients with infectious mononucleosis utilize the VH4-21 gene segment. J Immunol. 1993 Jul 15;151(2):1051-61. https://www.jimmunol.org/content/151/2/1051.long
  • Deane M, Mackenzie LE, Stevenson FK, Youinou PY, Lydyard PM, Mageed RA. The genetic basis of human VH4 gene family-associated cross-reactive idiotype expression in CD5+ and CD5- cord blood B-lymphocyte clones. Scand J Immunol. 1993 Oct;38(4):348-58. https://doi.org/10.1111/j.1365-3083.1993.tb01737.x
  • Isenberg D, Spellerberg M, Williams W, Griffiths M, Stevenson F. Identification of the 9G4 idiotope in systemic lupus erythematosus. Br J Rheumatol. 1993 Oct;32(10):876-82. https://doi.org/10.1093/rheumatology/32.10.876
  • Potter KN, Li Y, Pascual V, Williams RC Jr, Byres LC, Spellerberg M, Stevenson FK, Capra JD. Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment. J Exp Med. 1993 Oct 1;178(4):1419-28. https://doi.org/10.1084/jem.178.4.1419
  • Hawkins RE, Winter G, Hamblin TJ, Stevenson FK, Russell SJ. A genetic approach to idiotypic vaccination. J Immunother Emphasis Tumor Immunol. 1993 Nov;14(4):273-8. https://doi.org/10.1097/00002371-199311000-00004
  • Bhat NM, Bieber MM, Chapman CJ, Stevenson FK, Teng NN. Human antilipid A monoclonal antibodies bind to human B cells and the i antigen on cord red blood cells. J Immunol. 1993 Nov 1;151(9):5011-21. https://www.jimmunol.org/content/151/9/5011.long
  • Stevenson FK, Longhurst C, Chapman CJ, Ehrenstein M, Spellerberg MB, Hamblin TJ, Ravirajan CT, Latchman D, Isenberg D. Utilization of the VH4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus. J Autoimmun. 1993 Dec;6(6):809-25. https://doi.org/10.1006/jaut.1993.1066

1994

  • Stevenson FK, Spellerberg MB, Treasure J, Chapman CJ, Silberstein LE, Hamblin TJ, Jones DB. Differential usage of an autoantibody-associated VH gene by human B-cell tumors. In Zouali M, Ed. Autoimmunity: Experimental Aspects. NATO ASI Series (Series H: Cell Biology), vol 80. Berlin, Germany: Springer-Verlag; 1994: 163-172. https://doi.org/10.1007/978-3-642-78779-9_13
  • Roelcke D, Kreft H, Hack H, Stevenson FK. Anti-j: human cold agglutinins recognizing linear (i) and branched (I) type 2 chains. Vox Sang. 1994;67(2):216-21. https://doi.org/10.1111/j.1423-0410.1994.tb01663.x
  • Zhu D, Hawkins RE, Hamblin TJ, Stevenson FK. Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes. Br J Haematol. 1994 Mar;86(3):505-12. https://doi.org/10.1111/j.1365-2141.1994.tb04780.x
  • Hawkins RE, Zhu D, Ovecka M, Winter G, Hamblin TJ, Long A, Stevenson FK. Idiotypic vaccination against human B-cell lymphoma. Rescue of variable region gene sequences from biopsy material for assembly as single-chain Fv personal vaccines. Blood. 1994 Jun 1;83(11):3279-88. https://doi.org/10.1182/blood.V83.11.3279.bloodjournal83113279
  • Moazzeni M, Mosayyebi G, Stevenson FK, Abbot S, Mageed RA, Shokri F. Biased utilization of immunoglobulin variable region heavy- and light-chain genes by the malignant CD5- B lymphocytes from patients with Burkitt’s lymphoma. Int J Cancer. 1994 Jul 15;58(2):226-32. https://doi.org/10.1002/ijc.2910580214
  • Sahota S, Hamblin T, Oscier DG, Stevenson FK. Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma. Leukemia. 1994 Aug;8(8):1285-9.

1995

  • Smith G, Spellerberg M, Boulton F, Roelcke D, Stevenson F. The immunoglobulin VH gene, VH4-21, specifically encodes autoanti-red cell antibodies against the I or i antigens. Vox Sang. 1995;68(4):231-5. https://doi.org/10.1111/j.1423-0410.1995.tb02578.x
  • Spellerberg MB, Chapman CJ, Mockridge CI, Isenberg DA, Stevenson FK. Dual recognition of lipid A and DNA by human antibodies encoded by the VH4-21 gene: a possible link between infection and lupus. Hum Antibodies Hybridomas. 1995;6(2):52-6.
  • Stevenson FK, Spellerberg MB, Chapman CJ, Hamblin TJ. Differential usage of an autoantibody-associated VH gene, VH4-21, by human B-cell tumors. Leuk Lymphoma. 1995 Feb;16(5-6):379-84. https://doi.org/10.3109/10428199509054423
  • Zhu D, Oscier DG, Stevenson FK. Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes. Blood. 1995 Mar 15;85(6):1603-7. https://doi.org/10.1182/blood.V85.6.1603.bloodjournal8561603
  • Chapman CJ, Spellerberg MB, Hamblin TJ, Stevenson FK. Pattern of usage of the VH4-21 gene by B lymphocytes in a patient with EBV infection indicates ongoing mutation and class switching. Mol Immunol. 1995 Apr;32(5):347-53. https://doi.org/10.1016/0161-5890(94)00162-T
  • Chapman CJ, Mockridge CI, Rowe M, Rickinson AB, Stevenson FK. Analysis of VH genes used by neoplastic B cells in endemic Burkitt’s lymphoma shows somatic hypermutation and intraclonal heterogeneity. Blood. 1995 Apr 15;85(8):2176-81. https://doi.org/10.1182/blood.V85.8.2176.bloodjournal8582176
  • Snow RE, Chapman CJ, Frew AJ, Holgate ST, Stevenson FK. Analysis of Ig VH region genes encoding IgE antibodies in splenic B lymphocytes of a patient with asthma. J Immunol. 1995 May 15;154(10):5576-81. https://www.jimmunol.org/content/154/10/5576.long
  • Stevenson FK, Zhu D, King CA, Ashworth LJ, Kumar S, Hawkins RE. Idiotypic DNA vaccines against B-cell lymphoma. Immunol Rev. 1995 Jun;145:211-28. https://doi.org/10.1111/j.1600-065x.1995.tb00083.x
  • Kraj P, Friedman DF, Stevenson F, Silberstein LE. Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire. J Immunol. 1995 Jun 15;154(12):6406-20. https://www.jimmunol.org/content/154/12/6406.long
  • Børretzen M, Chapman C, Stevenson FK, Natvig JB, Thompson KM. Structural analysis of VH4-21 encoded human IgM allo- and autoantibodies against red blood cells. Scand J Immunol. 1995 Jul;42(1):90-7. https://doi.org/10.1111/j.1365-3083.1995.tb03630.x
  • Chapman C, Spellerberg M, Hamblin T, Stevenson F. Pattern of usage of the VH4-21 gene by B lymphocytes in a patient with EBV infection indicates ongoing mutation and class switching. Ann N Y Acad Sci. 1995 Sep 29;764:195-7. https://doi.org/10.1111/j.1749-6632.1995.tb55827.x
  • Spellerberg M, Chapman C, Hamblin T, Stevenson F. Dual recognition of lipid A and DNA by human antibodies encoded by the VH4-21 gene. A possible link between infection and lupus. Ann N Y Acad Sci. 1995 Sep 29;764:427-32. https://doi.org/10.1111/j.1749-6632.1995.tb55858.x
  • Chapman CJ, Mockridge CI, Spellerberg MB, Isenberg DA, Hamblin TJ, Stevenson FK. Use of a phage expression system to produce Fabs from human autoanti-DNA antibodies encoded by the VH4-21 gene segment. Ann N Y Acad Sci. 1995 Sep 29;764:576-9. https://doi.org/10.1111/j.1749-6632.1995.tb55886.x
  • Stevenson FK. Hodgkin’s disease–new insights from immunoglobulin genetics. N Engl J Med. 1995 Oct 5;333(14):934-6. https://doi.org/10.1056/NEJM199510053331411
  • Stevenson FK, Zhu D, King CA, Ashworth LJ, Kumar S, Thompsett A, Hawkins RE. A genetic approach to idiotypic vaccination for B cell lymphoma. Ann N Y Acad Sci. 1995 Nov 27;772:212-26. https://doi.org/10.1111/j.1749-6632.1995.tb44747.x

1996

  • Brissinck J, Zhang J, Shaw M, Stevenson F, Hawkins R, Russell S. Idiotypic vaccination against low grade follicular B cell lymphoma. In Touraine JL, Traeger J, Bétuel H, Dubernard JM, Revillard JP, Dupuy C, Eds. Cancer in Transplantation: Prevention and Treatment. Dordrecht, Netherlands: Springer; 1996: 299-304. https://doi.org/10.1007/978-94-009-0175-9_33
  • Snow RE, Chapman CJ, Holgate ST, Stevenson FK. Immunogenetics of human IgE. Hum Antibodies Hybridomas. 1996;7(4):157-66.
  • Sahota SS, Leo R, Hamblin TJ, Stevenson FK. Ig VH gene mutational patterns indicate different tumor cell status in human myeloma and monoclonal gammopathy of undetermined significance. Blood. 1996 Jan 15;87(2):746-55. https://doi.org/10.1182/blood.V87.2.746.bloodjournal872746
  • Chapman CJ, Dunn-Walters DK, Stevenson FK, Hussell T, Isaacson PG, Spencer J. Sequence analysis of immunoglobulin variable region genes that encode autoantibodies expressed by lymphomas of mucosa associated lymphoid tissue. Clin Mol Pathol. 1996 Feb;49(1):M29-32. https://doi.org/10.1136/mp.49.1.m29
  • Longhurst C, Ehrenstein MR, Leaker B, Stevenson FK, Spellerberg M, Chapman C, Latchmen D, Isenberg DA, Cambridge G. Analysis of immunoglobulin variable region genes of a human IgM anti-myeloperoxidase antibody derived from a patient with vasculitis. Immunology. 1996 Feb;87(2):334-8. https://doi.org/10.1046/j.1365-2567.1996.463529.x
  • Li Y, Spellerberg MB, Stevenson FK, Capra JD, Potter KN. The I binding specificity of human VH 4-34 (VH 4-21) encoded antibodies is determined by both VH framework region 1 and complementarity determining region 3. J Mol Biol. 1996 Mar 1;256(3):577-89. https://doi.org/10.1006/jmbi.1996.0110
  • Stevenson F. Molecular vaccines in infection and cancer. Leuk Res. 1996 Apr;20(4):365-6. https://doi.org/10.1016/0145-2126(95)00088-7
  • Stevenson FK, Snow RE, Chapman CJ, Frew AJ, Holgate ST. Genetic analysis of IgE. Thorax. 1996 May;51(5):458-60. https://doi.org/10.1136/thx.51.5.458
  • Bhat NM, Bieber MM, Stevenson FK, Teng NN. Rapid cytotoxicity of human B lymphocytes induced by VH4-34 (VH4.21) gene-encoded monoclonal antibodies. Clin Exp Immunol. 1996 Jul;105(1):183-90. https://doi.org/10.1046/j.1365-2249.1996.d01-733.x
  • Chapman CJ, Mockridge CI, Hamblin TJ, Stevenson FK. Tracking of the V4-34 (VH4-21) gene in human tonsil reveals clonal isotype switch events and a highly variable degree of somatic hypermutation. Clin Exp Immunol. 1996 Aug;105(2):360-8. https://doi.org/10.1046/j.1365-2249.1996.d01-769.x
  • Mockridge CI, Chapman CJ, Spellerberg MB, Isenberg DA, Stevenson FK. Use of phage surface expression to analyze regions of human V4-34(VH4-21)-encoded IgG autoantibody required for recognition of DNA: no involvement of the 9G4 idiotope. J Immunol. 1996 Sep 15;157(6):2449-54. https://www.jimmunol.org/content/157/6/2449.long
  • Dighiero G, Kipps T, Schroeder HW, Chiorazzi N, Stevenson F, Silberstein LE, Caligaris-Cappio F, Ferrarini M. What is the CLL B-lymphocyte? Leuk Lymphoma. 1996 Oct;22 Suppl 2:13-39. https://doi.org/10.3109/10428199609102700
  • Fais F, Sellars B, Ghiotto F, Yan XJ, Dono M, Allen SL, Budman D, Dittmar K, Kolitz J, Lichtman SM, Schulman P, Schuster M, Vinciguerra VP, Rai K, Stevenson FK, Gregersen PK, Ferrarini M, Chiorazzi N. Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells. J Clin Invest. 1996 Oct 1;98(7):1659-66. https://doi.org/10.1172/JCI118961
  • Chapman CJ, Zhou JX, Gregory C, Rickinson AB, Stevenson FK. VH and VL gene analysis in sporadic Burkitt’s lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection. Blood. 1996 Nov 1;88(9):3562-8. https://doi.org/10.1182/blood.V88.9.3562.bloodjournal8893562

1997

  • Chapman CJ, Mockridge CI, Spellerberg MB, Zhu D, Stevenson FK. Phage surface expression for analysis of recognition sites of human autoantibodies: comparison of single chain Fv and Fab. Hum Antibodies. 1997;8(3):124-8. https://doi.org/10.3233/HAB-1997-8303
  • Stevenson FK, Silverman GJ. Expression of anti-DNA antibodies. Lupus. 1997;6(3):321-3. https://doi.org/10.1177/096120339700600322
  • Snow RE, Chapman CJ, Frew AJ, Holgate ST, Stevenson FK. Pattern of usage and somatic hypermutation in the V(H)5 gene segments of a patient with asthma: implications for IgE. Eur J Immunol. 1997 Jan;27(1):162-70. https://doi.org/10.1002/eji.1830270124
  • Sahota SS, Leo R, Hamblin TJ, Stevenson FK. Myeloma VL and VH gene sequences reveal a complementary imprint of antigen selection in tumor cells. Blood. 1997 Jan 1;89(1):219-26. https://doi.org/10.1182/blood.V89.1.219
  • Bhat NM, Bieber MM, Hsu FJ, Chapman CJ, Spellerberg M, Stevenson FK, Teng NN. Rapid cytotoxicity of human B lymphocytes induced by VH4-34 (VH4.21) gene-encoded monoclonal antibodies, II. Clin Exp Immunol. 1997 Apr;108(1):151-9. https://doi.org/10.1046/j.1365-2249.1997.d01-976.x
  • Mockridge I, Chapman C, Spellerberg M, Isenberg D, Stevenson F. Use of phage expression to analyze regions of a human V4-34(VH4-21)-encoded IgG autoantibody required for recognition of DNA. No involvement of the 9G4 idiotope. Ann N Y Acad Sci. 1997 Apr 5;815:338-41. https://doi.org/10.1111/j.1749-6632.1997.tb52079.x
  • Zhu D, Spellerberg MB, Thompsett A, King CA, Hamblin TJ, Stevenson FK. DNA vaccination as cancer immunotherapy. Biochem Soc Trans. 1997 May;25(2):743-7. https://doi.org/10.1042/bst0250743
  • Oscier DG, Thompsett A, Zhu D, Stevenson FK. Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities. Blood. 1997 Jun 1;89(11):4153-60. https://doi.org/10.1182/blood.V89.11.4153
  • Hawkins RE, Russell SJ, Marcus R, Ashworth LJ, Brissnik J, Zhang J, Winter G, Bleehen NM, Shaw MM, Williamson L, Ouwehand W, Stevenson F, Hamblin T, Oscier D, Zhu D, King C, Kumar S, Thompsett A, Stevenson GT. A pilot study of idiotypic vaccination for follicular B-cell lymphoma using a genetic approach. CRC NO: 92/33. Protocol NO: PH1/027. Hum Gene Ther. 1997 Jul 1;8(10):1287-99. https://doi.org/10.1089/hum.1997.8.10-1287
  • Spellerberg MB, Zhu D, Thompsett A, King CA, Hamblin TJ, Stevenson FK. DNA vaccines against lymphoma: promotion of anti-idiotypic antibody responses induced by single chain Fv genes by fusion to tetanus toxin fragment C. J Immunol. 1997 Aug 15;159(4):1885-92. https://www.jimmunol.org/content/159/4/1885.long
  • Thorpe SJ, Boult CE, Stevenson FK, Scott ML, Sutherland J, Spellerberg MB, Natvig JB, Thompson KM. Cold agglutinin activity is common among human monoclonal IgM Rh system antibodies using the V4-34 heavy chain variable gene segment. Transfusion. 1997 Nov-Dec;37(11-12):1111-6. https://doi.org/10.1046/j.1537-2995.1997.37111298088038.x

1998

  • Snow RE, Chapman CJ, Stevenson FK. Allergen recognition sites in immunoglobulin E from patients with asthma. In Holgate ST, Busse WW, Eds. Inflammatory mechanisms in asthma. New York, NY: Marcel Dekker; 1998: 323-341.
  • Thorpe SJ, Turner CE, Stevenson FK, Spellerberg MB, Thorpe R, Natvig JB, Thompson KM. Human monoclonal antibodies encoded by the V4-34 gene segment show cold agglutinin activity and variable multireactivity which correlates with the predicted charge of the heavy-chain variable region. Immunology. 1998 Jan;93(1):129-36. https://doi.org/10.1046/j.1365-2567.1998.00406.x
  • Sahota SS, Garand R, Bataille R, Smith AJ, Stevenson FK. VH gene analysis of clonally related IgM and IgG from human lymphoplasmacytoid B-cell tumors with chronic lymphocytic leukemia features and high serum monoclonal IgG. Blood. 1998 Jan 1;91(1):238-43. https://doi.org/10.1182/blood.V91.1.238
  • Zhu D, van Arkel C, King CA, Meirvenne SV, de Greef C, Thielemans K, Radl J, Stevenson FK. Immunoglobulin VH gene sequence analysis of spontaneous murine immunoglobulin-secreting B-cell tumours with clinical features of human disease. Immunology. 1998 Feb;93(2):162-70. https://doi.org/10.1046/j.1365-2567.1998.00428.x
  • Janezic A, Chapman CJ, Snow RE, Hourihane JO, Warner JO, Stevenson FK. Immunogenetic analysis of the heavy chain variable regions of IgE from patients allergic to peanuts. J Allergy Clin Immunol. 1998 Mar;101(3):391-6. https://doi.org/10.1016/S0091-6749(98)70253-2
  • Stevenson F, Sahota S, Zhu D, Ottensmeier C, Chapman C, Oscier D, Hamblin T. Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes. Immunol Rev. 1998 Apr;162:247-59. https://doi.org/10.1111/j.1600-065x.1998.tb01446.x
  • Thomson RK, Davis Z, Palmer JM, Arthur MJ, Yeaman SJ, Chapman CJ, Spellerberg MB, Stevenson FK. Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-PDC-E2/X antibodies derived from patients with primary biliary cirrhosis. J Hepatol. 1998 Apr;28(4):582-94. https://doi.org/10.1016/s0168-8278(98)80281-x
  • Ottensmeier CH, Thompsett AR, Zhu D, Wilkins BS, Sweetenham JW, Stevenson FK. Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression. Blood. 1998 Jun 1;91(11):4292-9. https://doi.org/10.1182/blood.V91.11.4292
  • Chapman CJ, Wright D, Stevenson FK. Insight into Burkitt’s lymphoma from immunoglobulin variable region gene analysis. Leuk Lymphoma. 1998 Jul;30(3-4):257-67. https://doi.org/10.3109/10428199809057539
  • Isenberg DA, McClure C, Farewell V, Spellerberg M, Williams W, Cambridge G, Stevenson F. Correlation of 9G4 idiotope with disease activity in patients with systemic lupus erythematosus. Ann Rheum Dis. 1998 Sep;57(9):566-70. https://doi.org/10.1136/ard.57.9.566
  • Mockridge CI, Chapman CJ, Spellerberg MB, Sheth B, Fleming TP, Isenberg DA, Stevenson FK. Sequence analysis of V(4-34)-encoded antibodies from single B cells of two patients with systemic lupus erythematosus (SLE). Clin Exp Immunol. 1998 Oct;114(1):129-36. https://doi.org/10.1046/j.1365-2249.1998.00703.x
  • Snow RE, Chapman CJ, Holgate ST, Stevenson FK. Clonally related IgE and IgG4 transcripts in blood lymphocytes of patients with asthma reveal differing patterns of somatic mutation. Eur J Immunol. 1998 Oct;28(10):3354-61. https://doi.org/10.1002/(SICI)1521-4141(199810)28:10%3C3354::AID-IMMU3354%3E3.0.CO;2-Z
  • King CA, Spellerberg MB, Zhu D, Rice J, Sahota SS, Thompsett AR, Hamblin TJ, Radl J, Stevenson FK. DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma. Nat Med. 1998 Nov;4(11):1281-6. https://doi.org/10.1038/3266
  • Chapman CJ, Wright D, Feizi HP, Davis Z, Stevenson FK. V(H) gene analysis of Burkitt’s lymphoma in children from north-western Iran. Br J Haematol. 1998 Dec;103(4):1116-23. https://doi.org/10.1046/j.1365-2141.1998.01125.x

1999

  • Thomas MD, Clough K, Melamed MD, Stevenson FK, Chapman CJ, Spellerberg MB, Potter KN, Newton-Bishop JA, Gregson N, Dawson K. A human monoclonal antibody encoded by the V4-34 gene segment recognises melanoma-associated ganglioside via CDR3 and FWR1. Hum Antibodies. 1999;9(2):95-106. https://doi.org/10.3233/HAB-1999-9203
  • Stevenson F, Anderson KC. Introduction: immunotherapy for multiple myeloma–insights and advances. Semin Hematol. 1999 Jan;36(1 Suppl 3):1-2.
  • Stevenson FK, Link CJ Jr, Traynor A, Yu H, Corr M. DNA vaccination against multiple myeloma. Semin Hematol. 1999 Jan;36(1 Suppl 3):38-42.
  • Stevenson FK, Sahota SS. B cell maturation in relation to multiple myeloma. Pathol Biol (Paris). 1999 Feb;47(2):89-97.
  • Stevenson FK, King CA, Spellerberg MB, Zhu D, Rice J, Sahota S, Thompsett A, Radl J, Hamblin TJ. DNA vaccines against haematological malignancies. Haematologica. 1999 Jun;84 Suppl EHA-4:11-3.
  • Stevenson FK, Natvig J. Autoantibodies revealed: the role of B cells in autoimmune disease. Immunol Today. 1999 Jul;20(7):296-8. https://doi.org/10.1016/s0167-5699(98)01421-2
  • Sahota SS, Garand R, Mahroof R, Smith A, Juge-Morineau N, Stevenson FK, Bataille R. V(H) gene analysis of IgM-secreting myeloma indicates an origin from a memory cell undergoing isotype switch events. Blood. 1999 Aug 1;94(3):1070-6. https://doi.org/10.1182/blood.V94.3.1070.415k25_1070_1076
  • Rice J, King CA, Spellerberg MB, Fairweather N, Stevenson FK. Manipulation of pathogen-derived genes to influence antigen presentation via DNA vaccines. Vaccine. 1999 Aug 6;17(23-24):3030-8. https://doi.org/10.1016/s0264-410x(99)00171-1
  • Thompsett AR, Ellison DW, Stevenson FK, Zhu D. V(H) gene sequences from primary central nervous system lymphomas indicate derivation from highly mutated germinal center B cells with ongoing mutational activity. Blood. 1999 Sep 1;94(5):1738-46. https://doi.org/10.1182/blood.V94.5.1738
  • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999 Sep 15;94(6):1848-54. https://doi.org/10.1182/blood.V94.6.1848.418k05_1848_1854
  • Zhu D, Thompsett AR, Bedu-Addo G, Stevenson FK, Bates I. VH gene sequences from a novel tropical splenic lymphoma reveal a naive B cell as the cell of origin. Br J Haematol. 1999 Oct;107(1):114-20. https://doi.org/10.1046/j.1365-2141.1999.01679.x
  • Snow RE, Djukanovic R, Stevenson FK. Analysis of immunoglobulin E VH transcripts in a bronchial biopsy of an asthmatic patient confirms bias towards VH5, and indicates local clonal expansion, somatic mutation and isotype switch events. Immunology. 1999 Dec;98(4):646-51. https://doi.org/10.1046/j.1365-2567.1999.00910.x
  • Stevenson FK. DNA vaccines against cancer: from genes to therapy. Ann Oncol. 1999 Dec;10(12):1413-8. https://doi.org/10.1023/a:1008395012716

2000

2001

  • Stevenson FK, Sahota SS, Ottensmeier CH, Zhu D, Forconi F, Hamblin TJ. The occurrence and significance of V gene mutations in B cell-derived human malignancy. Adv Cancer Res. 2001;83:81-116. https://doi.org/10.1016/s0065-230x(01)83004-9
  • Stevenson FK, Zhu D, Rice J. New strategies for vaccination and imunomodulation in NHL. Ann Hematol. 2001;80 Suppl 3:B132-4. https://doi.org/10.1007/PL00022778
  • Stevenson FK, Rosenberg W. DNA vaccination: a potential weapon against infection and cancer. Vox Sang. 2001 Jan;80(1):12-8. https://doi.org/10.1046/j.1423-0410.2001.00009.x
  • Potter KN, Thomson RK, Hamblin A, Richards SD, Lindsay JG, Stevenson FK. Immunogenetic analysis reveals that epitope shifting occurs during B-cell affinity maturation in primary biliary cirrhosis. J Mol Biol. 2001 Feb 9;306(1):37-46. https://doi.org/10.1006/jmbi.2000.4210
  • Savelyeva N, Munday R, Spellerberg MB, Lomonossoff GP, Stevenson FK. Plant viral genes in DNA idiotypic vaccines activate linked CD4+ T-cell mediated immunity against B-cell malignancies. Nat Biotechnol. 2001 Aug;19(8):760-4. https://doi.org/10.1038/90816
  • Rice J, Elliott T, Buchan S, Stevenson FK. DNA fusion vaccine designed to induce cytotoxic T cell responses against defined peptide motifs: implications for cancer vaccines. J Immunol. 2001 Aug 1;167(3):1558-65. https://doi.org/10.4049/jimmunol.167.3.1558
  • Forconi F, Sahota SS, Raspadori D, Mockridge CI, Lauria F, Stevenson FK. Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing. Blood. 2001 Aug 15;98(4):1174-81. https://doi.org/10.1182/blood.V98.4.1174
  • Zhu D, Rice J, Savelyeva N, Stevenson FK. DNA fusion vaccines against B-cell tumors. Trends Mol Med. 2001 Dec;7(12):566-72. https://doi.org/10.1016/s1471-4914(01)02126-8

2002

  • Zhu D, Stevenson FK. DNA gene fusion vaccines against cancer. Curr Opin Mol Ther. 2002 Feb;4(1):41-8.
  • Hamblin TJ, Orchard JA, Ibbotson RE, Davis Z, Thomas PW, Stevenson FK, Oscier DG. CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood. 2002 Feb 1;99(3):1023-9. https://doi.org/10.1182/blood.v99.3.1023
  • Thirdborough SM, Radcliffe JN, Friedmann PS, Stevenson FK. Vaccination with DNA encoding a single-chain TCR fusion protein induces anticlonotypic immunity and protects against T-cell lymphoma. Cancer Res. 2002 Mar 15;62(6):1757-60. https://cancerres.aacrjournals.org/content/62/6/1757.long
  • Stevenson FK, Anderson KC. Immunotherapy for multiple myeloma: insights from other models. Leuk Res. 2002 Apr;26(4):403-5. https://doi.org/10.1016/s0145-2126(01)00143-6
  • Zhu D, McCarthy H, Ottensmeier CH, Johnson P, Hamblin TJ, Stevenson FK. Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma. Blood. 2002 Apr 1;99(7):2562-8. https://doi.org/10.1182/blood.v99.7.2562
  • Sahota SS, Forconi F, Ottensmeier CH, Provan D, Oscier DG, Hamblin TJ, Stevenson FK. Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events. Blood. 2002 Aug 15;100(4):1505-7. https://doi.org/10.1182/blood.V100.4.1505.h81602001505_1505_1507
  • Forconi F, King CA, Sahota SS, Kennaway CK, Russell NH, Stevenson FK. Insight into the potential for DNA idiotypic fusion vaccines designed for patients by analysing xenogeneic anti-idiotypic antibody responses. Immunology. 2002 Sep;107(1):39-45. https://doi.org/10.1046/j.1365-2567.2002.01452.x
  • Potter KN, Hobby P, Klijn S, Stevenson FK, Sutton BJ. Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen. J Immunol. 2002 Oct 1;169(7):3777-82. https://doi.org/10.4049/jimmunol.169.7.3777
  • Rice J, Buchan S, Stevenson FK. Critical components of a DNA fusion vaccine able to induce protective cytotoxic T cells against a single epitope of a tumor antigen. J Immunol. 2002 Oct 1;169(7):3908-13. https://doi.org/10.4049/jimmunol.169.7.3908
  • Zhu D, Orchard J, Oscier DG, Wright DH, Stevenson FK. V(H) gene analysis of splenic marginal zone lymphomas reveals diversity in mutational status and initiation of somatic mutation in vivo. Blood. 2002 Oct 1;100(7):2659-61. https://doi.org/10.1182/blood-2002-01-0169
  • Rice J, de Lima B, Stevenson FK, Stevenson PG. A gamma-herpesvirus immune evasion gene allows tumor cells in vivo to escape attack by cytotoxic T cells specific for a tumor epitope. Eur J Immunol. 2002 Dec;32(12):3481-7. https://doi.org/10.1002/1521-4141(200212)32:12%3C3481::AID-IMMU3481%3E3.0.CO;2-J
  • Potter KN, Mockridge CI, Rahman A, Buchan S, Hamblin T, Davidson B, Isenberg DA, Stevenson FK. Disturbances in peripheral blood B cell subpopulations in autoimmune patients. Lupus. 2002 Dec 1;11(12):872-7. https://doi.org/10.1191/0961203302lu309oa

2003

  • Heslop HE, Stevenson FK, Molldrem JJ. Immunotherapy of hematologic malignancy. Hematology Am Soc Hematol Educ Program. 2003:331-49. https://doi.org/10.1182/asheducation-2003.1.331
  • Savelyeva N, Zhu D, Stevenson FK. Engineering DNA vaccines that include plant virus coat proteins. Biotechnol Genet Eng Rev. 2003;20:101-14. https://doi.org/10.1080/02648725.2003.10648039
  • Stevenson FK, King A, Ottensmeier CH. Vaccine therapy in NHL: future promises and current limitations. Leuk Lymphoma. 2003;44 Suppl 3:S85-90. https://doi.org/10.1080/10428190310001623711
  • Zhu D, Ottensmeier CH, Du MQ, McCarthy H, Stevenson FK. Incidence of potential glycosylation sites in immunoglobulin variable regions distinguishes between subsets of Burkitt’s lymphoma and mucosa-associated lymphoid tissue lymphoma. Br J Haematol. 2003 Jan;120(2):217-22. https://doi.org/10.1046/j.1365-2141.2003.04064.x
  • Lanham S, Hamblin T, Oscier D, Ibbotson R, Stevenson F, Packham G. Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia. Blood. 2003 Feb 1;101(3):1087-93. Epub 2002 Sep 26. https://doi.org/10.1182/blood-2002-06-1822
  • Sahota SS, Forconi F, Ottensmeier CH, Stevenson FK. Origins of the malignant clone in typical Waldenstrom’s macroglobulinemia. Semin Oncol. 2003 Apr;30(2):136-41. https://doi.org/10.1053/sonc.2003.50072
  • Potter KN, Orchard J, Critchley E, Mockridge CI, Jose A, Stevenson FK. Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire. Blood. 2003 Apr 15;101(8):3082-4. Epub 2002 Dec 12. https://doi.org/10.1182/blood-2002-08-2432
  • Zojer N, Ludwig H, Fiegl M, Stevenson FK, Sahota SS. Patterns of somatic mutations in VH genes reveal pathways of clonal transformation from MGUS to multiple myeloma. Blood. 2003 May 15;101(10):4137-9. Epub 2003 Jan 16. https://doi.org/10.1182/blood-2002-09-2825
  • Jardin F, Bastard C, Contentin N, Parmentier F, Picquenot JM, Tilly H, Stevenson FK, Sahota SS. Intronic BCL-6 mutations are preferentially targeted to the translocated allele in t(3;14)(q27;q32) non-Hodgkin B-cell lymphoma. Blood. 2003 Sep 1;102(5):1872-6. Epub 2003 May 29. https://doi.org/10.1182/blood-2002-12-3630
  • Padua RA, Larghero J, Robin M, le Pogam C, Schlageter MH, Muszlak S, Fric J, West R, Rousselot P, Phan TH, Mudde L, Teisserenc H, Carpentier AF, Kogan S, Degos L, Pla M, Bishop JM, Stevenson F, Charron D, Chomienne C. PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia. Nat Med. 2003 Nov;9(11):1413-7. Epub 2003 Oct 19. https://doi.org/10.1038/nm949
  • Cochran DA, Evans CA, Blinco D, Burthem J, Stevenson FK, Gaskell SJ, Whetton AD. Proteomic analysis of chronic lymphocytic leukemia subtypes with mutated or unmutated Ig V(H) genes. Mol Cell Proteomics. 2003 Dec;2(12):1331-41. Epub 2003 Oct 13. https://doi.org/10.1074/mcp.M300055-MCP200
  • McCarthy H, Ottensmeier CH, Hamblin TJ, Stevenson FK. Anti-idiotype vaccines. Br J Haematol. 2003 Dec;123(5):770-81. https://doi.org/10.1046/j.1365-2141.2003.04698.x

2004

  • Bona CA, Stevenson FK. B cells producing pathogenic autoantibodies. In Honjo T, Alt FW, Neuberger MS, Eds. Molecular Biology of B Cells. San Diego, CA: Elsevier Academic Press; 2004: 381-401. https://doi.org/10.1016/B978-012053641-2/50026-5
  • Stevenson FK, Rice J, Zhu D. Tumor vaccines. Adv Immunol. 2004;82:49-103. https://doi.org/10.1016/S0065-2776(04)82002-9
  • Mockridge CI, Rahman A, Buchan S, Hamblin T, Isenberg DA, Stevenson FK, Potter KN. Common patterns of B cell perturbation and expanded V4-34 immunoglobulin gene usage in autoimmunity and infection. Autoimmunity. 2004 Feb;37(1):9-15. https://doi.org/10.1080/08916930310001624656
  • Forconi F, Capello D, Berra E, Rossi D, Gloghini A, Cerri M, Muti G, Morra E, Paulli M, Magrini U, Lucioni M, Rambaldi A, Lauria F, Carbone A, Stevenson FK, Gaidano G. Incidence of novel N-glycosylation sites in the B-cell receptor of lymphomas associated with immunodeficiency. Br J Haematol. 2004 Mar;124(5):604-9. https://doi.org/10.1111/j.1365-2141.2004.04816.x
  • Forconi F, Sahota SS, Lauria F, Stevenson FK. Revisiting the definition of somatic mutational status in B-cell tumors: does 98% homology mean that a V(H)-gene is unmutated? Leukemia. 2004 Apr;18(4):882-3. https://doi.org/10.1038/sj.leu.2403312
  • Babbage G, Garand R, Robillard N, Zojer N, Stevenson FK, Sahota SS. Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events. Blood. 2004 Apr 1;103(7):2795-8. Epub 2003 Oct 9. https://doi.org/10.1182/blood-2003-05-1632
  • Stevenson FK. DNA vaccines and adjuvants. Immunol Rev. 2004 Jun;199:5-8. https://doi.org/10.1111/j.0105-2896.2004.00146.x
  • Stevenson FK, Rice J, Ottensmeier CH, Thirdborough SM, Zhu D. DNA fusion gene vaccines against cancer: from the laboratory to the clinic. Immunol Rev. 2004 Jun;199:156-80. https://doi.org/10.1111/j.0105-2896.2004.00145.x
  • Stevenson FK, Caligaris-Cappio F. Chronic lymphocytic leukemia: revelations from the B-cell receptor. Blood. 2004 Jun 15;103(12):4389-95. Epub 2004 Feb 12. https://doi.org/10.1182/blood-2003-12-4312
  • Rice J, Buchan S, Dewchand H, Simpson E, Stevenson FK. DNA fusion vaccines induce targeted epitope-specific CTLs against minor histocompatibility antigens from a normal or tolerized repertoire. J Immunol. 2004 Oct 1;173(7):4492-9. https://doi.org/10.4049/jimmunol.173.7.4492
  • Stevenson FK, Ottensmeier CH, Johnson P, Zhu D, Buchan SL, McCann KJ, Roddick JS, King AT, McNicholl F, Savelyeva N, Rice J. DNA vaccines to attack cancer. Proc Natl Acad Sci U S A. 2004 Oct 5;101 Suppl 2:14646-52. Epub 2004 Aug 3. https://doi.org/10.1073/pnas.0404896101
  • Forconi F, Sahota SS, Raspadori D, Ippoliti M, Babbage G, Lauria F, Stevenson FK. Hairy cell leukemia: at the crossroad of somatic mutation and isotype switch. Blood. 2004 Nov 15;104(10):3312-7. Epub 2004 Jul 29. https://doi.org/10.1182/blood-2004-03-0950

2005

2006

  • McCann KJ, Johnson PW, Stevenson FK, Ottensmeier CH. Universal N-glycosylation sites introduced into the B-cell receptor of follicular lymphoma by somatic mutation: a second tumorigenic event? Leukemia. 2006 Mar;20(3):530-4. https://doi.org/10.1038/sj.leu.2404095
  • Potter KN, Mockridge CI, Neville L, Wheatley I, Schenk M, Orchard J, Duncombe AS, Packham G, Stevenson FK. Structural and functional features of the B-cell receptor in IgG-positive chronic lymphocytic leukemia. Clin Cancer Res. 2006 Mar 15;12(6):1672-9. https://doi.org/10.1158/1078-0432.CCR-05-2164
  • Di Genova G, Roddick J, McNicholl F, Stevenson FK. Vaccination of human subjects expands both specific and bystander memory T cells but antibody production remains vaccine specific. Blood. 2006 Apr 1;107(7):2806-13. Epub 2005 Dec 8. https://doi.org/10.1182/blood-2005-08-3255
  • Babbage G, Ottensmeier CH, Blaydes J, Stevenson FK, Sahota SS. Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines. Cancer Res. 2006 Apr 15;66(8):3996-4000. https://doi.org/10.1158/0008-5472.CAN-05-3704
  • Stevenson FK, Rice J. Optimizing cancer immunotherapy trials: back to basics. Eur J Immunol. 2006 May;36(5):1070-3. https://doi.org/10.1002/eji.200636085
  • Rice J, Dunn S, Piper K, Buchan SL, Moss PA, Stevenson FK. DNA fusion vaccines induce epitope-specific cytotoxic CD8(+) T cells against human leukemia-associated minor histocompatibility antigens. Cancer Res. 2006 May 15;66(10):5436-42. https://doi.org/10.1158/0008-5472.CAN-05-3130
  • Sahota SS, Stevenson FK. Lineage complexity in multiple myeloma? Leuk Lymphoma. 2006 Sep;47(9):1997-8. https://doi.org/10.1080/10428190600758686
  • Radcliffe JN, Roddick JS, Friedmann PS, Stevenson FK, Thirdborough SM. Prime-boost with alternating DNA vaccines designed to engage different antigen presentation pathways generates high frequencies of peptide-specific CD8+ T cells. J Immunol. 2006 Nov 15;177(10):6626-33. https://doi.org/10.4049/jimmunol.177.10.6626
  • Sahota SS, Goonewardena CM, Cooper CD, Liggins AP, Ait-Tahar K, Zojer N, Stevenson FK, Banham AH, Pulford K. PASD1 is a potential multiple myeloma-associated antigen. Blood. 2006 Dec 1;108(12):3953-5. https://doi.org/10.1182/blood-2006-04-014621

2007

  • Stevenson FK, di Genova G, Ottensmeier C, Savelyeva N. Cancer vaccines. In Prendergast GC, Jaffee EM, Eds. Cancer Immunotherapy. Burlington, MA: Academic Press; 2007:183-204. https://doi.org/10.1016/B978-012372551-6/50075-4
  • Ghia P, Stamatopoulos K, Belessi C, Moreno C, Stilgenbauer S, Stevenson F, Davi F, Rosenquist R; European Research Initiative on CLL. ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia. Leukemia. 2007 Jan;21(1):1-3. https://doi.org/10.1038/sj.leu.2404457
  • Pickering BM, de Mel S, Lee M, Howell M, Habens F, Dallman CL, Neville LA, Potter KN, Mann J, Mann DA, Johnson PW, Stevenson FK, Packham G. Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells. Oncogene. 2007 Feb 22;26(8):1166-77. Epub 2006 Aug 21. https://doi.org/10.1038/sj.onc.1209897
  • Radcliffe CM, Arnold JN, Suter DM, Wormald MR, Harvey DJ, Royle L, Mimura Y, Kimura Y, Sim RB, Inogès S, Rodriguez-Calvillo M, Zabalegui N, de Cerio AL, Potter KN, Mockridge CI, Dwek RA, Bendandi M, Rudd PM, Stevenson FK. Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor. J Biol Chem. 2007 Mar 9;282(10):7405-15. Epub 2006 Dec 29. https://doi.org/10.1074/jbc.M602690200
  • Babbage G, Townsend M, Zojer N, Mockridge IC, Garand R, Barlogie B, Shaughnessy J Jr, Stevenson FK, Sahota SS. IgM-expressing Waldenstrom’s macroglobulinemia tumor cells reveal a potential for isotype switch events in vivo. Leukemia. 2007 Apr;21(4):827-30. Epub 2007 Feb 8. https://doi.org/10.1038/sj.leu.2404538
  • Mockridge CI, Potter KN, Wheatley I, Neville LA, Packham G, Stevenson FK. Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status. Blood. 2007 May 15;109(10):4424-31. Epub 2007 Jan 25. https://doi.org/10.1182/blood-2006-11-056648
  • Radcliffe JN, Roddick JS, Stevenson FK, Thirdborough SM. Prolonged antigen expression following DNA vaccination impairs effector CD8+ T cell function and memory development. J Immunol. 2007 Dec 15;179(12):8313-21. https://doi.org/10.4049/jimmunol.179.12.8313

2008

  • Zhu D, Williams JN, Rice J, Stevenson FK, Heckels JE, Christodoulides M. A DNA fusion vaccine induces bactericidal antibodies to a peptide epitope from the PorA porin of Neisseria meningitidis. Infect Immun. 2008 Jan;76(1):334-8. Epub 2007 Oct 29. https://doi.org/10.1128/IAI.00943-07
  • Furmanski AL, Ferreira C, Bartok I, Dimakou S, Rice J, Stevenson FK, Millrain MM, Simpson E, Dyson J. Public T cell receptor beta-chains are not advantaged during positive selection. J Immunol. 2008 Jan 15;180(2):1029-39. https://doi.org/10.4049/jimmunol.180.2.1029
  • Rice J, Ottensmeier CH, Stevenson FK. DNA vaccines: precision tools for activating effective immunity against cancer. Nat Rev Cancer. 2008 Feb;8(2):108-20. https://doi.org/10.1038/nrc2326
  • Thirdborough SM, Roddick JS, Radcliffe JN, Howarth M, Stevenson FK, Elliott T. Tapasin shapes immunodominance hierarchies according to the kinetic stability of peptide-MHC class I complexes. Eur J Immunol. 2008 Feb;38(2):364-9. https://doi.org/10.1002/eji.200737832
  • McCann KJ, Ottensmeier CH, Callard A, Radcliffe CM, Harvey DJ, Dwek RA, Rudd PM, Sutton BJ, Hobby P, Stevenson FK. Remarkable selective glycosylation of the immunoglobulin variable region in follicular lymphoma. Mol Immunol. 2008 Mar;45(6):1567-72. Epub 2007 Nov 19. https://doi.org/10.1016/j.molimm.2007.10.009
  • Rice J, Dossett ML, Ohlén C, Buchan SL, Kendall TJ, Dunn SN, Stevenson FK, Greenberg PD. DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire. Eur J Immunol. 2008 Aug;38(8):2118-30. https://doi.org/10.1002/eji.200838213
  • Chaise C, Buchan SL, Rice J, Marquet J, Rouard H, Kuentz M, Vittes GE, Molinier-Frenkel V, Farcet JP, Stauss HJ, Delfau-Larue MH, Stevenson FK. DNA vaccination induces WT1-specific T-cell responses with potential clinical relevance. Blood. 2008 Oct 1;112(7):2956-64. Epub 2008 May 23. https://doi.org/10.1182/blood-2008-02-137695

2009

  • McCann KJ, Ashton-Key M, Smith K, Stevenson FK, Ottensmeier CH. Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development. Blood. 2009 May 7;113(19):4677-80. Epub 2008 Dec 18. https://doi.org/10.1182/blood-2008-09-179366
  • Chen CG, Lu YT, Lin M, Savelyeva N, Stevenson FK, Zhu D. Amplification of immune responses against a DNA-delivered idiotypic lymphoma antigen by fusion to the B subunit of E. coli heat labile toxin. Vaccine. 2009 Jul 9;27(32):4289-96. Epub 2009 May 29. https://doi.org/10.1016/j.vaccine.2009.05.025
  • Low L, Mander A, McCann K, Dearnaley D, Tjelle T, Mathiesen I, Stevenson F, Ottensmeier CH. DNA vaccination with electroporation induces increased antibody responses in patients with prostate cancer. Hum Gene Ther. 2009 Nov;20(11):1269-78. https://doi.org/10.1089/hum.2009.067

2010

  • Forconi F, Potter KN, Wheatley I, Darzentas N, Sozzi E, Stamatopoulos K, Mockridge CI, Packham G, Stevenson FK. The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL. Blood. 2010 Jan 7;115(1):71-7. Epub 2009 Nov 3. https://doi.org/10.1182/blood-2009-06-225813
  • Di Genova G, Savelyeva N, Suchacki A, Thirdborough SM, Stevenson FK. Bystander stimulation of activated CD4+ T cells of unrelated specificity following a booster vaccination with tetanus toxoid. Eur J Immunol. 2010 Apr;40(4):976-85. https://doi.org/10.1002/eji.200940017
  • Stevenson FK, Ottensmeier CH, Rice J. DNA vaccines against cancer come of age. Curr Opin Immunol. 2010 Apr;22(2):264-70. Epub 2010 Feb 19. https://doi.org/10.1016/j.coi.2010.01.019
  • Stevenson FK, Palucka K. Understanding and activating immunity against human cancer. Curr Opin Immunol. 2010 Apr;22(2):212-4. Epub 2010 Mar 24. https://doi.org/10.1016/j.coi.2010.03.001
  • Krysov S, Potter KN, Mockridge CI, Coelho V, Wheatley I, Packham G, Stevenson FK. Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo. Blood. 2010 May 27;115(21):4198-205. Epub 2010 Mar 17. https://doi.org/10.1182/blood-2009-12-254847
  • Stevenson FK, Johnson PW. Harnessing innate immunity to suppress lymphoma. J Clin Oncol. 2010 Oct 1;28(28):4295-6. Epub 2010 Aug 9. https://doi.org/10.1200/JCO.2010.30.4212
  • Coelho V, Krysov S, Ghaemmaghami AM, Emara M, Potter KN, Johnson P, Packham G, Martinez-Pomares L, Stevenson FK. Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18587-92. Epub 2010 Oct 11. https://doi.org/10.1073/pnas.1009388107
  • Zuckerman NS, McCann KJ, Ottensmeier CH, Barak M, Shahaf G, Edelman H, Dunn-Walters D, Abraham RS, Stevenson FK, Mehr R. Ig gene diversification and selection in follicular lymphoma, diffuse large B cell lymphoma and primary central nervous system lymphoma revealed by lineage tree and mutation analyses. Int Immunol. 2010 Nov;22(11):875-87. Epub 2010 Nov 8. https://doi.org/10.1093/intimm/dxq441
  • Packham G, Stevenson F. The role of the B-cell receptor in the pathogenesis of chronic lymphocytic leukaemia. Semin Cancer Biol. 2010 Dec;20(6):391-9. Epub 2010 Sep 9. https://doi.org/10.1016/j.semcancer.2010.08.004

2011

  • Savelyeva N, Shipton M, Suchacki A, Babbage G, Stevenson FK. High-affinity memory B cells induced by conjugate vaccines against weak tumor antigens are vulnerable to nonconjugated antigen. Blood. 2011 Jul 21;118(3):650-9. Epub 2011 May 25. https://doi.org/10.1182/blood-2011-01-328864
  • Stevenson FK, Mander A, Chudley L, Ottensmeier CH. DNA fusion vaccines enter the clinic. Cancer Immunol Immunother. 2011 Aug;60(8):1147-51. Epub 2011 Jun 5. https://doi.org/10.1007/s00262-011-1042-2
  • Vittes GE, Harden EL, Ottensmeier CH, Rice J, Stevenson FK. DNA fusion gene vaccines induce cytotoxic T-cell attack on naturally processed peptides of human prostate-specific membrane antigen. Eur J Immunol. 2011 Aug;41(8):2447-56. Epub 2011 Jul 4. https://doi.org/10.1002/eji.201141518
  • Stevenson FK, Krysov S, Davies AJ, Steele AJ, Packham G. B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 2011 Oct 20;118(16):4313-20. Epub 2011 Aug 3. https://doi.org/10.1182/blood-2011-06-338855

2012

  • Krysov S, Dias S, Paterson A, Mockridge CI, Potter KN, Smith KA, Ashton-Key M, Stevenson FK, Packham G. Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells. Blood. 2012 Jan 5;119(1):170-9. Epub 2011 Nov 15. https://doi.org/10.1182/blood-2011-07-370403
  • Paterson A, Mockridge CI, Adams JE, Krysov S, Potter KN, Duncombe AS, Cook SJ, Stevenson FK, Packham G. Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia. Blood. 2012 Feb 16;119(7):1726-36. Epub 2011 Dec 7. https://doi.org/10.1182/blood-2011-07-367417
  • Forconi F, Potter KN, Sozzi E, Henderson I, Cencini E, Rossi D, Bomben R, Gattei V, Gaidano G, Packham G, Stevenson FK. The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells. Blood. 2012 Mar 1;119(9):2106-9. Epub 2012 Jan 10. https://doi.org/10.1182/blood-2011-08-375501
  • Stevenson FK, Stevenson GT. Follicular lymphoma and the immune system: from pathogenesis to antibody therapy. Blood. 2012 Apr 19;119(16):3659-67. Epub 2012 Feb 15. https://doi.org/10.1182/blood-2011-11-367730
  • Chudley L, McCann K, Mander A, Tjelle T, Campos-Perez J, Godeseth R, Creak A, Dobbyn J, Johnson B, Bass P, Heath C, Kerr P, Mathiesen I, Dearnaley D, Stevenson F, Ottensmeier C. DNA fusion-gene vaccination in patients with prostate cancer induces high-frequency CD8(+) T-cell responses and increases PSA doubling time. Cancer Immunol Immunother. 2012 Nov;61(11):2161-70. Epub 2012 May 22. https://doi.org/10.1007/s00262-012-1270-0

2013

  • Stevenson FK, di Genova G, Ottensmeier CH, Savelyeva N. Genetic vaccines against cancer: design, testing and clinical performance. In Prendergast GC, Jaffee EM, Eds. Cancer Immunotherapy. Second Edition. San Diego, CA: Academic Press; 2013: 223-239. https://doi.org/10.1016/B978-0-12-394296-8.00015-4
  • Apollonio B, Scielzo C, Bertilaccio MT, Ten Hacken E, Scarfò L, Ranghetti P, Stevenson F, Packham G, Ghia P, Muzio M, Caligaris-Cappio F. Targeting B-cell anergy in chronic lymphocytic leukemia. Blood. 2013 May 9;121(19):3879-88, S1-8. Epub 2013 Mar 4. https://doi.org/10.1182/blood-2012-12-474718
  • Hardwick N, Buchan S, Ingram W, Khan G, Vittes G, Rice J, Pulford K, Mufti G, Stevenson F, Guinn BA. An analogue peptide from the Cancer/Testis antigen PASD1 induces CD8+ T cell responses against naturally processed peptide. Cancer Immun. 2013 Jul 15;13:16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718735/
  • Campos-Perez J, Rice J, Escors D, Collins M, Paterson A, Savelyeva N, Stevenson FK. DNA fusion vaccine designs to induce tumor-lytic CD8+ T-cell attack via the immunodominant cysteine-containing epitope of NY-ESO 1. Int J Cancer. 2013 Sep 15;133(6):1400-7. Epub 2013 Apr 11. https://doi.org/10.1002/ijc.28156
  • Coelho V, Krysov S, Steele A, Sanchez Hidalgo M, Johnson PW, Chana PS, Packham G, Stevenson FK, Forconi F. Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function. Blood. 2013 Oct 10;122(15):2664-72. Epub 2013 Aug 16. https://doi.org/10.1182/blood-2013-02-485425

2014

  • Packham G, Krysov S, Allen A, Savelyeva N, Steele AJ, Forconi F, Stevenson FK. The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy. Haematologica. 2014 Jul;99(7):1138-48. https://doi.org/10.3324/haematol.2013.098384
  • Stevenson FK, Forconi F, Packham G. The meaning and relevance of B-cell receptor structure and function in chronic lymphocytic leukemia. Semin Hematol. 2014 Jul;51(3):158-67. Epub 2014 May 15. https://doi.org/10.1053/j.seminhematol.2014.05.003
  • Krysov S, Steele AJ, Coelho V, Linley A, Sanchez Hidalgo M, Carter M, Potter KN, Kennedy B, Duncombe AS, Ashton-Key M, Forconi F, Stevenson FK, Packham G. Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK. Blood. 2014 Nov 13;124(20):3101-9. Epub 2014 Aug 28. https://doi.org/10.1182/blood-2014-04-567198

2015

  • Jobsri J, Allen A, Rajagopal D, Shipton M, Kanyuka K, Lomonossoff GP, Ottensmeier C, Diebold SS, Stevenson FK, Savelyeva N. Plant virus particles carrying tumour antigen activate TLR7 and Induce high levels of protective antibody. PLoS One. 2015 Feb 18;10(2):e0118096. https://doi.org/10.1371/journal.pone.0118096
  • Pepper C, Buggins AG, Jones CH, Walsby EJ, Forconi F, Pratt G, Devereux S, Stevenson FK, Fegan C. Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kδ inhibition. Leukemia. 2015 Mar;29(3):744-7. Epub 2014 Oct 28. https://doi.org/10.1038/leu.2014.308
  • Schneider D, Dühren-von Minden M, Alkhatib A, Setz C, van Bergen CA, Benkißer-Petersen M, Wilhelm I, Villringer S, Krysov S, Packham G, Zirlik K, Römer W, Buske C, Stevenson FK, Veelken H, Jumaa H. Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma. Blood. 2015 May 21;125(21):3287-96. Epub 2015 Mar 17. https://doi.org/10.1182/blood-2014-11-609404
  • Blunt MD, Carter MJ, Larrayoz M, Smith LD, Aguilar-Hernandez M, Cox KL, Tipton T, Reynolds M, Murphy S, Lemm E, Dias S, Duncombe A, Strefford JC, Johnson PW, Forconi F, Stevenson FK, Packham G, Cragg MS, Steele AJ. The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model. Blood. 2015 Jun 25;125(26):4032-41. Epub 2015 May 8. https://doi.org/10.1182/blood-2014-11-610329
  • Linley A, Valle-Argos B, Steele AJ, Stevenson FK, Forconi F, Packham G. Higher levels of reactive oxygen species are associated with anergy in chronic lymphocytic leukemia. Haematologica. 2015 Jul;100(7):e265-8. Epub 2015 Mar 6. https://doi.org/10.3324/haematol.2014.120824
  • McCann KJ, Godeseth R, Chudley L, Mander A, Di Genova G, Lloyd-Evans P, Kerr JP, Malykh VB, Jenner MW, Orchard KH, Stevenson FK, Ottensmeier CH. Idiotypic DNA vaccination for the treatment of multiple myeloma: safety and immunogenicity in a phase I clinical study. Cancer Immunol Immunother. 2015 Aug;64(8):1021-32. Epub 2015 May 16. https://doi.org/10.1007/s00262-015-1703-7
  • Li Causi E, Parikh SC, Chudley L, Layfield DM, Ottensmeier CH, Stevenson FK, Di Genova G. Vaccination Expands Antigen-Specific CD4+ Memory T Cells and Mobilizes Bystander Central Memory T Cells. PLoS One. 2015 Sep 2;10(9):e0136717. https://doi.org/10.1371/journal.pone.0136717
  • Linley A, Krysov S, Ponzoni M, Johnson PW, Packham G, Stevenson FK. Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells. Blood. 2015 Oct 15;126(16):1902-10. Epub 2015 Jul 20. https://doi.org/10.1182/blood-2015-04-640805

2016

  • Yeomans A, Thirdborough SM, Valle-Argos B, Linley A, Krysov S, Hidalgo MS, Leonard E, Ishfaq M, Wagner SD, Willis AE, Steele AJ, Stevenson FK, Forconi F, Coldwell MJ, Packham G. Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation. Blood. 2016 Jan 28;127(4):449-57. Epub 2015 Oct 21. https://doi.org/10.1182/blood-2015-07-660969
  • Chotprakaikiat W, Allen A, Bui-Minh D, Harden E, Jobsri J, Cavallo F, Gleba Y, Stevenson FK, Ottensmeier C, Klimyuk V, Savelyeva N. A plant-expressed conjugate vaccine breaks CD4(+) tolerance and induces potent immunity against metastatic Her2(+) breast cancer. Oncoimmunology. 2016 Apr 22;5(6):e1166323. eCollection 2016 Jun. https://doi.org/10.1080/2162402X.2016.1166323
  • Aguilar-Hernandez MM, Blunt MD, Dobson R, Yeomans A, Thirdborough S, Larrayoz M, Smith LD, Linley A, Strefford JC, Davies A, Johnson PM, Savelyeva N, Cragg MS, Forconi F, Packham G, Stevenson FK, Steele AJ. IL-4 enhances expression and function of surface IgM in CLL cells. Blood. 2016 Jun 16;127(24):3015-25. Epub 2016 Mar 21. https://doi.org/10.1182/blood-2015-11-682906
  • Bollard CM, Stevenson FK. Introduction to a review series on advances in cell-based immune therapeutics in hematology. Blood. 2016 Jun 30;127(26):3293. Epub 2016 May 20. https://doi.org/10.1182/blood-2016-05-713255
  • D’Avola A, Drennan S, Tracy I, Henderson I, Chiecchio L, Larrayoz M, Rose-Zerilli M, Strefford J, Plass C, Johnson PW, Steele AJ, Packham G, Stevenson FK, Oakes CC, Forconi F. Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL. Blood. 2016 Aug 11;128(6):816-26. Epub 2016 Jun 14. https://doi.org/10.1182/blood-2016-03-707786
  • McCann KJ, Mander A, Cazaly A, Chudley L, Stasakova J, Thirdborough S, King A, Lloyd-Evans P, Buxton E, Edwards C, Halford S, Bateman A, O’Callaghan A, Clive S, Anthoney A, Jodrell DI, Weinschenk T, Simon P, Sahin U, Thomas GJ, Stevenson FK, Ottensmeier CH. Targeting carcinoembryonic antigen with DNA vaccination: on-target adverse events link with immunologic and clinical outcomes. Clin Cancer Res. 2016 Oct 1;22(19):4827-4836. Epub 2016 Apr 18. https://doi.org/10.1158/1078-0432.CCR-15-2507
  • Yeomans A, Lemm E, Wilmore S, Cavell BE, Valle-Argos B, Krysov S, Hidalgo MS, Leonard E, Willis AE, Forconi F , Stevenson FK, Steele AJ, Coldwell MJ, Packham G. PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells. Oncotarget. 2016 Nov 15;7(46):74807-74819. https://doi.org/10.18632/oncotarget.11655

2017

  • Savelyeva N, Allen A, Chotprakaikiat W, Harden E, Jobsri J, Godeseth R, Wang Y, Stevenson F, Ottensmeier C. Linked CD4 T cell help: broadening immune attack against cancer by vaccination. Curr Top Microbiol Immunol. 2017;405:123-143. https://doi.org/10.1007/82_2016_500
  • Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O’Brien S, Gribben J, Rai K. Chronic lymphocytic leukaemia. Nat Rev Dis Primers. 2017 Jan 19;3:16096. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336551/
  • Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O’Brien S, Gribben J, Rai K. Correction. Chronic lymphocytic leukaemia. Nat Rev Dis Primers. 2017 Feb 9;3:17008. https://doi.org/10.1038/nrdp.2017.8
  • Blunt MD, Koehrer S, Dobson RC, Larrayoz M, Wilmore S, Hayman A, Parnell J, Smith LD, Davies A, Johnson PWM, Conley PB, Pandey A, Strefford JC, Stevenson FK, Packham G, Forconi F, Coffey GP, Burger JA, Steele AJ. The dual Syk/JAK inhibitor cerdulatinib antagonizes B-cell receptor and microenvironmental signaling in chronic lymphocytic leukemia. Clin Cancer Res. 2017 May 1;23(9):2313-2324. Epub 2016 Oct 3. https://doi.org/10.1158/1078-0432.CCR-16-1662
  • Drennan S, D’Avola A, Gao Y, Weigel C, Chrysostomou E, Steele AJ, Zenz T, Plass C, Johnson PW, Williams AP, Packham G, Stevenson FK, Oakes CC, Forconi F. IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus. Leukemia. 2017 Aug;31(8):1686-1694. Epub 2016 Nov 28. https://doi.org/10.1038/leu.2016.356
  • Ghia P, Nadel B, Sander B, Stamatopoulos K, Stevenson FK. Early stages in the ontogeny of small B-cell lymphomas: genetics and microenvironment. J Intern Med. 2017 Nov;282(5):395-414. Epub 2017 Apr 10. https://doi.org/10.1111/joim.12608

2018

  • Stevenson FK, Bollard CM. Introduction to a review series on therapeutic antibodies. Blood. 2018 Jan 4;131(1):1. Epub 2017 Nov 8. https://doi.org/10.1182/blood-2017-10-798769
  • Allen A, Wang C, Caproni LJ, Sugiyarto G, Harden E, Douglas LR, Duriez PJ, Karbowniczek K, Extance J, Rothwell PJ, Orefo I, Tite JP, Stevenson FK, Ottensmeier CH, Savelyeva N. Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model. Cancer Immunol Immunother. 2018 Apr;67(4):627-638. Epub 2018 Jan 12. https://doi.org/10.1007/s00262-017-2111-y
  • Stevenson FK. Introduction to a review series on biological insights into lymphoid tumors. Blood. 2018 May 24;131(21):2275. Epub 2018 Apr 17. https://doi.org/10.1182/blood-2018-01-824052
  • Küppers R, Stevenson FK. Critical influences on the pathogenesis of follicular lymphoma. Blood. 2018 May 24;131(21):2297-2306. Epub 2018 Apr 17. https://doi.org/10.1182/blood-2017-11-764365

2019

  • Drennan S, Chiodin G, D’Avola A, Tracy I, Johnson PW, Trentin L, Steele AJ, Packham G, Stevenson FK, Forconi F. Ibrutinib therapy releases leukemic surface IgM from antigen drive in chronic lymphocytic leukemia patients. Clin Cancer Res. 2019 Apr 15;25(8):2503-2512. Epub 2018 Oct 29. https://doi.org/10.1158/1078-0432.CCR-18-1286

2020

  • Chiorazzi N, Stevenson FK. Celebrating 20 Years of IGHV Mutation Analysis in CLL. Hemasphere. 2020 Jan 22;4(1):e334. eCollection 2020 Feb. https://doi.org/10.1097/HS9.0000000000000334
  • Smith LD, Minton AR, Blunt MD, Karydis LI, Dutton DA, Rogers-Broadway KR, Dobson R, Liu R, Norster F, Hogg E, Ashton-Key M, Strefford JC, Jia L, Efremov DG, Helgason GV, Johnson PWM, Stevenson FK, Forconi F, Cragg MS, Tumbarello DA, Packham G, Steele AJ. BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia. Leukemia. 2020 Feb;34(2):640-644. Epub 2019 Aug 28. https://doi.org/10.1038/s41375-019-0557-y
  • Bollard CM, Stevenson FK. Introduction to a review series on understanding and treating primary immunodeficiency. Blood. 2020 Feb 27;135(9):591. https://doi.org/10.1182/blood.2019004081
  • Odabashian M, Carlotti E, Araf S, Okosun J, Spada F, Gribben JG, Forconi F, Stevenson FK, Calaminici M, Krysov S. IGHV sequencing reveals acquired N-glycosylation sites as a clonal and stable event during follicular lymphoma evolution. Blood. 2020 Mar 12;135(11):834-844. https://doi.org/10.1182/blood.2019002279
  • Lemm EA, Valle-Argos B, Smith LD, Richter J, Gebreselassie Y, Carter MJ, Karolova J, Svaton M, Helman K, Weston-Bell NJ, Karydis L, Williamson CT, Lenz G, Pettigrew J, Harwig C, Stevenson FK, Cragg M, Forconi F, Steele AJ, Cross J, Mackenzie L, Klener P, Packham G. Preclinical evaluation of a novel SHIP1 phosphatase activator for inhibition of PI3K signaling in malignant B-cells. Clin Cancer Res. 2020 Apr 1;26(7):1700-1711. Epub 2019 Dec 12. https://doi.org/10.1158/1078-0432.CCR-19-2202

Page last updated on May 21, 2020.

%d bloggers like this: